[Effect of 6-methyluracil on regulatory parameters of lipid peroxidation in thermal burn]. / Vliianie 6-metiluratsila na parametry sistemy reguliatsii peroksidnogo okisleniia lipidov pri termicheskom ozhoge.

The effects of 6-methyluracil given in single intraperitoneal doses of 50 and 2.7 mg/kg on the healing of burn wounds and some physicochemical parameters of lipid peroxidation regulation were studied in the liver and erythrocytes of noninbred albino rats with thermal burns. 6-Methyluracil was shown to alter the time course of a wound process and to accelerate the healing of burn wounds. The drug doses under study were found to exert a great effect on the level of lipid antioxidative activity and the composition of phospholipids of the liver and erythrocytes, which remained for a long time after burn. The findings suggest the hypothesis that the capacity of 6-methyluracil to be involved in the regulation of lipid peroxidation processes underlies its therapeutic effect.

[The effect of the antioxidant potassium fenozan on the course of acute alcoholic intoxication]. / Vliianie antioksidanta fenozana kaliia na techenie ostroi alkogol'noi intoksikatsii.

A screening of antialcohol effect of potassium phenosane has been carried out. A modification of test for alcohol intoxication has been proposed. Potassium phenosane was found to possess antialcoholic properties in different doses (0.01, 2.5, and 5 mg/kg).

[Effect of water-soluble antioxidants on the permeability of lysosomal membranes and on the structure of the liver in rats with thermal burns]. / Vliianie vodorastvorimykh antioksidantov na pronitsaemost' lizosomal'nykh membran i na strukturu pecheni krys pri termicheskom ozhoge.

Experiments on rats were made to study the effect of water-soluble antioxidants on the permeability of lysosomal membranes of liver cells and liver structure under burn. Antioxidants were injected intraperitoneally shortly after burn, whereas examination was performed after one day. It has been discovered that one day after burn there takes place an appreciable destabilization of lysosomal membranes with the release of a lysosomal matrix enzyme, cathepsin D to the cytoplasm. Liver structure had undergone substantial changes by that time. After administration of water-soluble antioxidants lysosomal membranes got stabilized while liver structure manifested but insignificant disorders.

Effect of N-nitrosomethylurea on substrains of Fisher lymphadenosis L-5178 resistant to antitumoral antibiotics.

A cytogenetic analysis of variants of Fisher mouse lymphadenosis L-5178 resistant to the antitumoral antibiotics bruneomycin and rubomycin C showed that the cytogenetic characteristics of the changes in the tumor cell population correlate with the chemotherapeutic indices of the development of drug resistance. Cytogenetic and kinetic analyses showed that variants of Fisher lymphadenosis L-5178 resistant to bruneomycin and rubomycin C retain sensitivity to N-nitrosomethylurea (NMU). The activity of NMU in an experiment on resistant substrains of lymphadenosis can serve as a basis for the clinical use of NMU in the treatment of lymphomas resistant to antibiotics.

[Polymorphism of a tumor ce-l population and selection processes. IV. The effect of dibunol and nitrosourea on the variability of Ehrlich-I. Ch. Ph. ascitic strain tumor cells]. / Polimorfizm populiatsii opukholevykh kletok i selektivnye protsessy. IV. Vliianie dibunola i nitrozomocheviny na izmenchivost' opukholevykh kletok astsitnogo shtamma Erlikha-IKhF.

A study was made of the effect of dibunol and methyl-N-nitrosourea (MNU) on two tumor cell subpopulations of the Ehrlich-I. Ch. Ph. ascites strain, one of which is characterized with A + B + 2C and A + D + 2C--markers and the other one--with A1 + A2 + 2B + D + C markers. Dibunol that belongs to the class of inhibitors of free-radical processes was shown to bring about changes in cell subpopulations, the mode of changes depending on the dose and regime of treatment. The effect of MNU on the population resulted predominantly in the accumulation of cells with various chromosome aberrations. At early stages of tumor progression, aberrations were more pronounced in cells with marker chromosome "A" than in the cells with 44 chromosomes and markers A1 + A2 + 2B + D + C.

[Polymorphism of a tumor cell population and selective processes. III. A change in the correlation of tumor cell subpopulations of the ascitic strain of Ehrlich-I.Ch.Ph. under the influence of glucose and sodium succinate]. / Polimorfizm populiatsii opukholevykh kletok i selektivnye protsessy. III. Izmenenie sootnosheniia subpopuliatsii opukholevykh kletok astsitnogo shtamma Erlikha-TKhF pod vliianiem gliukozy i suktsinata natriia.

A study was made of the action of glucose or sodium succinate on subpopulations of the Ehrlich-I.Ch.Ph. ascite strain characterised by markers "A1" and "A", resp. After i.p. injection of glucose the amount of "A1"-cell reached 50 and almost 100% on the 5th and 7th day of tumor growth. After the transplantation of "A1"-cells into intact animals, a homogenous cytogenetic feature of subpopulation persisted during 2 passages only. Kinetics studies of a subvariance of the Ehrlich-I.Ch.Ph. tumor containing "A1"-cells show that the tumor growth rate and grade of malignancy slightly differ from those seen in the controls.

[Polymorphism of a tumor cell population and selective processes. II. Change in the correlation of the numbers of 2 subpopulations of Ehrlich-Ich Ph ascites tumor cells in mice under the action of cell-free ascitic fluid and its fractions]. / Polimorfizm populiatsii opukholevykh klétok i selektivnye protsessy. II. Izmenenie sootnosheniia chislennostei dvukh subpopuliatsii opukholevykh kletok astsitnogo shtamma Erlikha-IKhF myshei pri deistvii beskletochni astsiticheskoi zhidkosti i ee fraktsii.

After repeated injections to mice of cell-free fluid the inhibition of growth of ascitic cell number was noticed already on the 5th day after transplantation of tumor. It was found that the inhibition of growth was due to the death of cells having 45 chromosomes, and containing A + B + 2C- and A + D + 2C-markers.

[Polymorphism of a population of tumor cells and selective processes. I. Ehrlich-IChPh ascitic strain tumor cell subpopulation]. / Polimorfizm populiatsii opukholevykh kletok i selektivnye protsessy. I. Subpopuliatsii opukholevykh kletok astsitnogo shtamma Erlikha-IKhF.

4 types of marker chromosomes and of their combination in mouse ascite Ehrlich-I. Ch. Ph. tumor cells are described. Two most frequently encountered subpopulations of cells are found in the tumor: one--with A+B+2C and A+D+2D markers, and the other--with A1+A2+2B+D1+C markers. The former population dominated during 8 days, to be gradually substituted with the former subpopulation. Changes in the number of cells with certain chromosome number in the near-diploid and near-tetraploid cell zones were followed within one passage.

[Cytogenetic characteristics of the growth of mouse ascitic strain L-5178]. / Tsitogeneticheskaia kharakteristika rosta astsitnogo shtamma L-5178 myshei

The number of chromosomes in the cells of L-5178 ascites tumor vary from 38 to 46. The modal class consists of two cell lines with 43 and 44 chromosomes. The number of polyploid cells changes in the process of tumor growth from 11% within first 10 days after transplantation to 50% on the 21st-22en days. The tumor cell population manifests a number of metaphases with endoreduplication of chromosomes. The per cent of metaphases with diplochromosomes varies from 0.05% on the 7th day of tumor development to 5.0% on the 15th-17th day. L-5178 tumor cells are characterized by the presence of structurally changed chromosomes: the acrocentric chromosome with the secondary constriction, metacentric, and 2-3 small chromosomes.