RESUMO
Violation of qualitative and quantitative composition of the microflora of the intestinal tract has a negative effect on the body and conduces to formation of pathosis. As a result of our study we have the date which confirmed the relevance between the functional status of hepatobiliary system, status of lipid exchange and violations of the microflora of the large intestine. Therefore, apparently, that the preservation and sustentation of normal microflora of the intestinal tract are the most important components determining the health status of the person and microecological approaches to the understanding of the development of the pathosis can be the starting point of the creation of new methods of treatment.
Assuntos
Colagogos e Coleréticos/uso terapêutico , Colo/microbiologia , Fígado Gorduroso/microbiologia , Fármacos Gastrointestinais/uso terapêutico , Lactulose/uso terapêutico , Ácido Ursodesoxicólico/uso terapêutico , Colagogos e Coleréticos/administração & dosagem , Colo/efeitos dos fármacos , Relação Dose-Resposta a Droga , Esquema de Medicação , Quimioterapia Combinada , Fígado Gorduroso/tratamento farmacológico , Fígado Gorduroso/etiologia , Fezes/microbiologia , Feminino , Fármacos Gastrointestinais/administração & dosagem , Humanos , Lactulose/administração & dosagem , Testes de Função Hepática , Masculino , Pessoa de Meia-Idade , Ácido Ursodesoxicólico/administração & dosagemRESUMO
Coronary heart disease and other diseases caused by atherosclerosis, take first place among the causes of adult mortality. Leading role in the development of atherosclerosis belongs to violations of cholesterol metabolism. Reducing mortality from ischemic heart disease primarily associated with adequate correction of the lipid metabolism. The research of the possible causes and correction of resistant hypercholesterolemia is done. Determined that some patients with resistant to statins hypercholesteremia and normal or elevated levels of hormones T3 and T4 in the blood have isolated symptoms of hypothyroidism, which may be a manifestation of reducing tissue sensitivity to thyroid hormones. Adding to the statins levothyroxine in daily doses of 25-50 mkg have additional cholesterol reducing action, allowing to achieve target levels of lipoprotein in blood in patients. The use of levothyroxine in low doses in combination with statins is highly effective and economically justified.