RESUMO
Idiopathic facial aseptic granuloma is a chronic, benign, and painless facial nodule occurring exclusively in childhood. Its pathogenesis is unclear, although some interesting hypotheses have been advanced. On the basis of the relationship existing between this disease and recurrent chalazions and conjunctivitis, we hypothesize that it could be considered to be a possible marker of childhood rosacea.
Assuntos
Dermatoses Faciais/diagnóstico por imagem , Dermatoses Faciais/etiologia , Granuloma/complicações , Granuloma/diagnóstico por imagem , Rosácea/complicações , Rosácea/diagnóstico por imagem , Idade de Início , Pré-Escolar , Feminino , Humanos , UltrassonografiaRESUMO
Drug-induced pemphigus is a well-established variety of pemphigus, presenting with clinical and histopathologic features identical to idiopathic form. Medical history plays a fundamental role in the diagnosis of drug-induced pemphigus. A large variety of drugs have been implicated in its pathogenesis and they may induce acantholysis via biochemical and/or immune mechanism. We present a case of a 69-year-old woman affected by amoxicillin/clavulanic acid-induced pemphigus and discuss its pathogenetic mechanism.
Assuntos
Combinação Amoxicilina e Clavulanato de Potássio/efeitos adversos , Antibacterianos/efeitos adversos , Pênfigo/induzido quimicamente , Idoso , Feminino , Humanos , Pênfigo/imunologia , Pênfigo/patologia , Pênfigo/fisiopatologiaRESUMO
An 82-year-old man with hypothyroidism presented with an ulcerated nodule on the dorsum of his left hand (Figure 1). The lesion had been present for about 3 months. Similar lesions were present along the lymphatic distribution of the dorsum of his left forearm, proximal to the first lesion, as well as the dorsum of his right forearm. Laboratory findings were normal. Immune complexes, complement 3, and complement 4 were negative. A biopsy from an ulcerated nodule was taken for both histologic examination and culture. Hematoxylin and eosin sections showed a nonspecific chronic granulomatous reaction. No fungi were detected by periodic acid-Schiff stain and methenamine silver stain. Culture of tissue obtained from a skin biopsy of 1 lesion placed directly on Sabouraud agar produced colonies of Sporothrix schenckii (Figure 2). The diagnosis of lymphocutaneous sporotrichosis was confirmed.
Assuntos
Antifúngicos/uso terapêutico , Dermatoses da Mão/tratamento farmacológico , Itraconazol/uso terapêutico , Esporotricose/tratamento farmacológico , Idoso de 80 Anos ou mais , Humanos , Masculino , Indução de RemissãoRESUMO
An 11-month-old male infant was referred to our clinic because of a painful ulcer of approximately 5 months' duration on the ventral surface of the tongue (Fig. 1). On physical examination, the lesion was circular (3 cm x 2 cm) with erythematous, raised, and indurated borders. No pathologic findings emerged from the laboratory data, neurologic examination, or clinical history. The family history was also negative for developmental disorders and congenital syndromes. No biopsy was performed in view of the age of the infant, the particular site of the lesion, and the clinical evidence of diagnosis. The treatment included odontologic cream (methylvinylether/maleic acid) as a protective shield, a collutorium (chlorhexidine 0.2%), and the use of a teething ring. Complete healing of the lesion (Fig. 2) occurred within 3 weeks.
