Micropulse transscleral cyclophotocoagulation (MP-CPC): efficacy endpoints for the treatment of refractory paediatric glaucoma - a retrospective case-series.

BACKGROUND: This study evaluates the efficacy and safety of micropulse transscleral cyclophotocoagulation (MP-CPC) in paediatric patients. METHODS: This retrospective case-series recruited 44 eyes for glaucoma patients who were younger than 17 years and were treated with MP-CPC and followed for at least one year. Pre- and post-intervention intraocular pressure (IOP) was compared out to at least one year postoperatively. Success rates at 6 months and 1 year postoperatively were assessed. P < 0.05 was considered statistically significant. RESULTS: There were 35 (79.5%) eyes with a history of glaucoma surgery. IOP decreased statistically significantly from a baseline of 32.7 (standard deviation:8.7 mmHg) to 23.2 (8.6) and 21.7 (7.9) mmHg at the 6 months and 1-year follow-up, respectively (P < 0.0001, all comparisons). Overall success was noted in 19 (47.5%) eyes at the 6 months follow-up, and 23 (53.5%) eyes at 1 year. CONCLUSIONS: MP-CPC reduces IOP and the burden of medications in paediatric patients with glaucoma. Additionally, its safety profile favours the use of MP-CPC as an adjunctive modality for refractory glaucoma.

Prevalence and Factors of Anxiety and Depression in Chronic Kidney Disease Patients Undergoing Hemodialysis: A Cross-sectional Single-Center Study in Saudi Arabia.

Introduction Mood disorders, including anxiety and depression, are prevalent among patients with chronic kidney disease (CKD) who are on hemodialysis. Anxiety and\or depressive symptoms among those patients have been associated with early initiation of dialysis and adverse outcome. Aim The aim is to investigate the prevalence and factors associated with anxiety and depression among Saudi patients with CKD who are on hemodialysis. Methods This is a cross-sectional study. A total of 122 patients with CKD and on hemodialysis at King Fahad Hospital in Al-Madinah, Saudi Arabia, were included in the study during the period from November 2017 to August 2018. Data were collected using the Hospital Anxiety and Depression Scale questionnaire. Sociodemographic information, duration of illness, and duration of hemodialysis were determined. Results Of the 122 CKD patients, 24.6% had depression and 19.7% had anxiety symptoms. Anxiety symptoms were more prevalent among females than males (P = 0.04). Older age was significantly associated with depression (P = 0.003). Patients' depression and anxiety symptoms were insignificantly associated with their education level, employment status, duration of illness, and duration of hemodialysis. Conclusion Anxiety and depression are prevalent among CKD patients, particularly among females and older patients. Thus, this study suggests establishing a screening program to determine patients who are at risk of developing anxiety and depression. In addition, management to prevent the occurrence of depression and anxiety and improve patients' quality of life must be implemented.