Assuntos
Epilepsia/cirurgia , Transtornos da Personalidade/etiologia , Personalidade/fisiologia , Complicações Pós-Operatórias , Psicocirurgia/efeitos adversos , Lobo Temporal/cirurgia , Adolescente , Adulto , Epilepsia/complicações , Epilepsia/história , Feminino , História do Século XX , Humanos , Inteligência/fisiologia , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos , Avaliação de Processos e Resultados em Cuidados de Saúde , Transtornos da Personalidade/história , Psicocirurgia/história , Sexualidade/psicologia , Comportamento SocialRESUMO
Very few cases have been reported of a successful outcome after relief by operation of severe visual failure from a pituitary or other parasellar tumour during the late stages of pregnancy. Two such cases are recorded here together with the obstetric features and follow-up studies of more than three years. Usually the deterioration of vi sion occurs in the latter half of the pregnancy and recovers rapidly after delivery, whether the onset of labour has occurred spontaneously or after induction. In subsequent pregnancies vision deteriorates at an earlier stage and becomes even more marked. Some cases are now occurring even in pregnancies induced by modern fertility drugs. The treatment of choice whenever vision is seriously threatened at any stage of pregnancy is a surgical attack on the pituitary, followed by suitable replacement therapy to ensure that the pregnancy continues.
Assuntos
Adenoma Cromófobo/complicações , Neoplasias Hipofisárias/complicações , Complicações na Gravidez/cirurgia , Transtornos da Visão/etiologia , Adenoma Cromófobo/cirurgia , Adulto , Feminino , Seguimentos , Humanos , Neoplasias Hipofisárias/cirurgia , Gravidez , Transtornos da Visão/cirurgiaRESUMO
Temporal-lobe epilepsy commonly has its origins in childhood, particularly when the lesion involved is mesial temporal (Ammon's horn) Sclerosis. Evidence suggests that this lesion is probably a common cause of chronic epilepsy in adults and that often it is probably the result of a severe febrile convulsion in infancy. 40 children, fifteen years of age and younger, who had an anterior temporal lobectomy were followed up for one to twenty-four years. The findings confirm those already established in adults, that the best results of surgery, not only in seizure relief but also in behaviour, are obtained when mesial temporal sclerosis is the lesion found at operation, and also indicate that a severe febrile convulsion in infancy is often the chief provocative factor in the development of epilepsy.
Assuntos
Epilepsia do Lobo Temporal/cirurgia , Adaptação Psicológica , Adolescente , Comportamento , Encefalopatias/complicações , Neoplasias Encefálicas/complicações , Neoplasias Encefálicas/patologia , Criança , Pré-Escolar , Epilepsia/etiologia , Epilepsia do Lobo Temporal/patologia , Seguimentos , Hamartoma/complicações , Hamartoma/patologia , Hipocampo , Humanos , Lactente , Esclerose/complicações , Esclerose/etiologia , Esclerose/patologia , Convulsões/complicações , Ajustamento SocialRESUMO
Routine pre-operative EEG studies as well as direct brain recording and stimulation carried out during operations were analysed for 59 patients subjected to a standard unilateral anterior temporal lobectomy for the treatment of epilepsy. All patients in the present series were 16 years old or older at the time of operation, which was invariably carried out under local scalp analgesia only. Electrophysiological findings was correlated with pathological changes noted in the resected temporal lobes, and with the effects of surgery upon seizure activity. Pre-operative EEG data correlated with each of four pathological categories when sphenoidal electrodes and intravenous barbiturate narcosis were emplyed. Thirty of 31 patients with mesial temporal sclerosis demonstrated medial temporal primary spike foci, frequently with independent contralateral and extratemporal secondary foci. In addition, one-third of these patients demonstrated unilateral focal decreased barbiturate-induced fast activity in the corresponding sphenoidal to ear channels. Twelve patients with other specific medial focal lesions (mostly hamartomas) also had medial temporal primary foci, often with independent contralateral secondaries but never with extratemporal foci. Two patients in this group also demonstrated focal decreased fast activity in the appropriate sphenoidal-ear channel. Both of these groups did very well post-operatively with respect to their epilepsy. Five patients with large temporal convexity cicatrices antedating seizures all demonstrated lateral temporal primary spike foci without independent secondary foci or focal decreased fast activity and did not do as well post-operatively as the first two groups. Eleven patients had only non-specific changes in the resected temporal lobe and in general did not benefit from surgery. Various combinations of primary and independent secondary spike foci were seen. Only this group demonstrated diffuse or bifrontal spikes during initial EEG recording, and basal mid-line spikes with intravenous thiopentone. Pecilar sharp notched spike were also very common in this group, but not unique to it. Focal decreases in barbiturate-induced fast activity were not noted.
Assuntos
Eletroencefalografia , Epilepsia do Lobo Temporal/fisiopatologia , Psicocirurgia , Lobo Temporal/cirurgia , Adolescente , Adulto , Tonsila do Cerebelo/patologia , Encefalopatias/complicações , Encefalopatias/patologia , Lesões Encefálicas/complicações , Neoplasias Encefálicas/complicações , Neoplasias Encefálicas/patologia , Cicatriz , Estimulação Elétrica , Epilepsia do Lobo Temporal/diagnóstico , Epilepsia do Lobo Temporal/etiologia , Epilepsia do Lobo Temporal/patologia , Epilepsia do Lobo Temporal/cirurgia , Feminino , Hamartoma/complicações , Hamartoma/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Esclerose , Lobo Temporal/patologiaAssuntos
Epilepsia do Lobo Temporal/cirurgia , Adolescente , Fatores Etários , Criança , Pré-Escolar , Seguimentos , Humanos , Masculino , Lobo Temporal/cirurgiaAssuntos
Encefalopatias/complicações , Epilepsia do Lobo Temporal/etiologia , Hipocampo/patologia , Esclerose/complicações , Administração Oral , Adolescente , Animais , Encefalopatias/patologia , Criança , Pré-Escolar , Diazepam/uso terapêutico , Epilepsia do Lobo Temporal/prevenção & controle , Haplorrinos , Humanos , Lactente , Papio , Fenobarbital/administração & dosagem , Fenobarbital/uso terapêutico , Esclerose/patologia , Convulsões/complicações , Convulsões/tratamento farmacológicoAssuntos
Química Encefálica , Fenobarbital/sangue , Fenitoína/sangue , Adolescente , Adulto , Pré-Escolar , Cromatografia Gasosa , Epilepsia do Lobo Temporal/cirurgia , Feminino , Humanos , Masculino , Proteínas do Tecido Nervoso/metabolismo , Fenobarbital/líquido cefalorraquidiano , Fenitoína/líquido cefalorraquidiano , Primidona/farmacologia , Ligação Proteica , Lobo Temporal/cirurgia , UltrafiltraçãoAssuntos
Anticonvulsivantes/efeitos adversos , Doenças em Gêmeos , Face , Acromegalia/induzido quimicamente , Adulto , Anticonvulsivantes/uso terapêutico , Carbamazepina/efeitos adversos , Criança , Diazepam/efeitos adversos , Epilepsia/complicações , Epilepsia/genética , Epilepsia Tônico-Clônica/complicações , Epilepsia Tônico-Clônica/tratamento farmacológico , Epilepsia Tônico-Clônica/cirurgia , Etossuximida/efeitos adversos , Feminino , Haloperidol/efeitos adversos , Humanos , Hidantoínas , Masculino , Fenobarbital/efeitos adversos , Fenitoína/efeitos adversos , Primidona/efeitos adversos , TiazinasAssuntos
Epilepsia do Lobo Temporal/cirurgia , Lobo Temporal/cirurgia , Adolescente , Adulto , Agressão , Tonsila do Cerebelo/patologia , Neoplasias Encefálicas/complicações , Neoplasias Encefálicas/patologia , Esclerose Cerebral Difusa de Schilder/patologia , Epilepsia do Lobo Temporal/complicações , Epilepsia do Lobo Temporal/patologia , Feminino , Seguimentos , Hamartoma/complicações , Hamartoma/patologia , Hipocampo/patologia , Humanos , Infarto/patologia , Masculino , Pessoa de Meia-Idade , Esquizofrenia/etiologia , Ajustamento Social , Lobo Temporal/patologiaAssuntos
Encéfalo/cirurgia , Epilepsia do Lobo Temporal/cirurgia , Lobo Temporal/cirurgia , Adolescente , Encéfalo/diagnóstico por imagem , Criança , Comportamento Infantil , Eletroencefalografia , Epilepsia do Lobo Temporal/tratamento farmacológico , Feminino , Humanos , Inteligência , Masculino , Pneumoencefalografia , Cuidados Pré-Operatórios , Lobo Temporal/fisiopatologiaAssuntos
Epilepsia do Lobo Temporal/cirurgia , Hipocampo , Esclerose/cirurgia , Lobo Temporal/cirurgia , Adolescente , Criança , Pré-Escolar , Diagnóstico Diferencial , Epilepsia do Lobo Temporal/complicações , Epilepsia do Lobo Temporal/diagnóstico , Epilepsia do Lobo Temporal/epidemiologia , Epilepsia do Lobo Temporal/patologia , Feminino , Hipocampo/patologia , Humanos , Masculino , Esclerose/etiologiaRESUMO
An unusual microscopic abnormality has been identified in the lobectomy specimens removed surgically from the brains of 10 epileptic patients. The abnormality could seldom be identified by palpation or with the naked eye. Histologically, it consisted of congregations of large, bizarre neurones which were littered through all but the first cortical layer. In most, but not in all cases, grotesque cells, probably of glial origin, were also present in the depths of the affected cortex and in the subjacent white matter. This kind of abnormality appears to be a malformation. The picture is reminiscent of tuberous sclerosis but too many distinguishing features, both in the clinical and in the pathological aspects, make this diagnosis untenable. The cases are therefore looked on provisionally (since all but one are still alive) as comprising a distinct form of cortical dysplasia in which localized, exotic populations of nerve cells underlie the electrical and clinical manifestations of certain focal forms of epilepsy.