N-Doping-Induced Amorphization for Achieving Ultrastable Aqueous Zinc-Ion Batteries.

Vanadium-based oxides, known for their high capacity and low cost, have garnered significant attention as promising cathode candidates in aqueous zinc-ion batteries. Nonetheless, their poor rate performance and limited durability in aqueous electrolytes present a challenge to the realistic implementation of vanadium-based aqueous zinc-ion batteries. Here, we synthesized nitrogen-doped V2O3@C (N-V2O3@N-C) via ammonia treatment of V2O3@C derived from vanadium-based metal-organic framework (V-MOF), aiming to achieve outstanding rate and cycling performance. The N-V2O3@N-C electrode exhibits notable in situ self-transformation into an amorphous state. Density functional theory calculations reveal that the distorted N-V2O3 structure and uneven charge distribution result in the creation of an amorphous state. As expected, Zn/N-V2O3@N-C aqueous zinc-ion batteries can achieve remarkable specific capacity (349.0 mAh g-1 at 0.1 A g-1), along with impressive rate performance, showcasing a capacity of 253.5 mAh g-1 at 5 A g-1 and exceptional durability at 5 A g-1 (96.4% after 1350 cycles). The employed induced amorphization approach offers novel perspectives for designing high-performance cathodes that exhibit both sturdy structures and extended cycling lifespans.

Sulfate radical dominated rapid pollutants degradation leaded by selenium vacancies in core-shell N-doped carbon wrapped cobalt diselenide nanospheres.

Herein, a new heterogeneous CoSe2-x@NC material with abundant selenium vacancies is synthesized via an in-situ carbonization-selenization process from cobaltic metal organic framework (Co-MOF). The obtained CoSe2-x@NC has a unique electronic structure and rich active sites, which can activate peroxymonosulfate (PMS) to degrade carbamazepine (CBZ) with superior catalytic performance and stability. The quenchingexperiments and EPR test show that SO4•- is the dominant reactive oxidation species (ROSs) for CBZ degradation. Significantly, systemic electrochemical tests and theoretical calculations illustrated that the dominant role of SO4•- is attributed to the existence of abundant selenium vacancies in CoSe2-x@NC, which can adjust the density of electron cloud of the Co atoms in CoSe2-x@NC to improve the PMS adsorption and promoting the conversion of transition metallic redox pairs (Co3+/Co2+). This work provides a facile way to improve the activity and stability of CoSe2 by defect engineering in the PMS based advanced oxidation process (AOPs).

Facile synthesis of pyrite FeS2 on carbon spheres for high-efficiency Fenton-like reaction.

Designing iron-based catalysts for Fenton-like reactions with peroxymonosulfate (PMS) as oxidants have attracted growing attentions. Herein, pyrite FeS2 supported on carbon spheres (FeS2@C) is synthesized by a facile low-temperature method. The FeS2@C/PMS system can degrade carbamazepine (CBZ) effectively in a wide pH range. Sulfate radicals (SO4·-), hydroxyl radicals (·OH), superoxide radical (O2·-), and singlet oxygen (1O2) are the responsible reactive oxygen species (ROSs) for CBZ degradation. Moreover, in the simulated fixed-bed reactor, the FeS2@C/PMS system can maintain a high CBZ removal ratio of >95% for than 8 h, exhibiting its excellent stability. The outstanding performance of FeS2@C/PMS system is attributed to the presence of carbon spheres and lattice S2-, which together promote the Fe(III)/Fe(II) redox cycle. The FeS2@C is a promising catalyst due to its facile synthesis, low cost, high efficiency, and excellent stability to activate PMS for organics degradation.

Enabling Uniform and Stable Lithium-Ion Diffusion at the Ultrathin Artificial Solid-Electrolyte Interface in Siloxene Anodes.

Constructing a stable and robust solid electrolyte interphase (SEI) has a decisive influence on the charge/discharge kinetics of lithium-ion batteries (LIBs), especially for silicon-based anodes which generate repeated destruction and regeneration of unstable SEI films. Herein, a facile way is proposed to fabricate an artificial SEI layer composed of lithiophilic chitosan on the surface of two-dimensional siloxene, which has aroused wide attention as an advanced anode for LIBs due to its special characteristics. The optimized chitosan-modified siloxene anode exhibits an excellent reversible cyclic stability of about 672.6 mAh g-1 at a current density of 1000 mA g-1 after 200 cycles and 139.9 mAh g-1 at 6000 mA g-1 for 1200 cycles. Further investigation shows that a stable and LiF-rich SEI film is formed and can effectively adhere to the surface during cycling, redistribute lithium-ion flux, and enable a relatively homogenous lithium-ion diffusion. This work provides constructive guidance for interface engineering strategy of nano-structured silicon anodes.

N-Terminalized Ti3 C2 Tx MXene for Supercapacitor with Extraordinary Pseudocapacitance Performance.

MXenes have demonstrated significant potential in electrochemical energy storage, particularly in supercapacitors, owing to their exceptional properties. The surface terminal groups of MXene play a pivotal role in pseudocapacitive mechanism. Considering the hindered electrolyte ion transport caused by -F terminal groups and the limited ion binding sites associated with -O terminal groups, this study proposes a novel strategy of replacing -F with -N terminal groups. The modulated MXene-N electrode, featuring a substantial number of -N terminal groups, demonstrates an exceptionally high gravimetric capacitance of 566 F g-1 (at a scan rate of 2 mV s-1 ) or 588 F g-1 (at a discharge rate of 1 A g-1 ) in 1 м H2 SO4 electrolyte, and the potential window is significantly increased. Furthermore, subsequent spectra analysis and density functional theory calculations are employed to investigate the mechanism associated with -N terminal groups. This work exemplifies the significance of terminal modulation in the context of electrochemical energy storage.

Decrypting the circular RNAs does a favor for us: Understanding, diagnosing and treating diabetes mellitus and its complications.

Circular RNAs (circRNAs), a novel type of single-stranded noncoding RNAs with a covalently closed loop structure, are generated in a circular conformation via non-canonical splicing or back-splicing events. Functionally, circRNAs have been elucidated to soak up microRNAs (miRNAs) and RNA binding proteins (RBPs), serve as protein scaffolds, maintain mRNA stability, and regulate gene transcription and translation. Notably, circRNAs are strongly implicated in the regulation of ß-cell functions, insulin resistance, adipocyte functions, inflammation as well as oxidative stress via acting as miRNA sponges and RBP sponges. Basic and clinical studies have demonstrated that aberrant alterations of circRNAs expressions are strongly associated with the initiation and progression of diabetes mellitus (DM) and its complications. Here in this review, we present a summary of the biogenesis, transportation, degradation and functions of circRNAs, and highlight the recent findings on circRNAs and their action mechanisms in DM and its complications. Overall, this review should contribute greatly to our understanding of circRNAs in DM pathogenesis, offering insights into the further perspectives of circRNAs for DM diagnosis and therapy.

Labor Induction After Severe Preeclampsia With Maternal Posterior Reversible Encephalopathy Syndrome Complications Leading to Intrauterine Fetal Death: A Case Report.

Posterior reversible encephalopathy syndrome (PRES) is a clinical imaging syndrome characterized by vasogenic edema in the posterior cerebral circulation, with severe preeclampsia (PE) and eclampsia as major etiologies. Posterior reversible encephalopathy syndrome lesions are often reversible, but they can be potentially fatal in obstetric crises, causing serious complications such as cerebral hemorrhage, confusion, headache, visual symptoms, and stroke if not treated immediately. Neurological sequelae and even death may occur in a minority of these cases. In this paper, we report the case of a 26-year-old primigravida at 25 weeks of gestation who was irregular with obstetric visits. The patient presented with edema, nausea and vomiting, dizziness, blurry vision, falling down, and a maximum blood pressure of 190/85 mmHg. A brain MRI revealed PRES. Approximately 10 hours after admission, intrauterine fetal death occurred. After treatment, the patient was in stable condition and successfully induced for delivery.

Coating CoFe2O4 shell on Fe particles to increase the utilization efficiencies of Fe and peroxymonosulfate for low-cost Fenton-like reactions.

Bimetallic composites (Fe@CoFe2O4) with zero-valent Fe as the core encapsulated by CoFe2O4 layers are synthesized by a coprecipitation-calcination method, which are applied to activate PMS for the degradation of bisphenol A (BPA). Enhanced activity of Fe@CoFe2O4 is achieved with very fast degradation rate (kobs = 0.5737 min-1). In the fixed-bed reactor, the catalyst lifetime (tul) of Fe@CoFe2O4 is determined to be 22 h compared to 11 h of Fe, and the deactivation rate constant (kd) for Fe@CoFe2O4 is 0.0083 mg·L-1·h-1, only ∼1/10 of Fe (0.0731). The XPS results indicate that the core-shell structure of Fe@CoFe2O4 could promote the redox cycles of Co3+/Co2+ and Fe3+/Fe2+. It is proved that the coating of CoFe2O4 shell on Fe0 can protect the Fe0 core from being oxidized by PMS to form passivation layer. The electrons of Fe0 can therefore be used effectively for activating PMS to produce ROSs via the CoFe2O4 shell. This modification method of Fe0 would decrease the cost of PMS based wastewater remediation greatly, thus should have great potential on an industrial scale.

Aberrant hyper-expression of the RNA binding protein GIGYF2 in endothelial cells modulates vascular aging and function.

Vascular endothelial cells (ECs) senescence plays a crucial role in vascular aging that promotes the initiation and progression of cardiovascular disease. The mutation of Grb10-interacting GYF protein 2 (GIGYF2) is strongly associated with the pathogenesis of aging-related diseases, whereas its role in regulating ECs senescence and dysfunction still remains elusive. In this study, we found aberrant hyperexpression of GIGYF2 in senescent human ECs and aortas of old mice. Silencing GIGYF2 in senescent ECs suppressed eNOS-uncoupling, senescence, and endothelial dysfunction. Conversely, in nonsenescent cells, overexpressing GIGYF2 promoted eNOS-uncoupling, cellular senescence, endothelial dysfunction, and activation of the mTORC1-SK61 pathway, which were ablated by rapamycin or antioxidant N-Acetyl-l-cysteine (NAC). Transcriptome analysis revealed that staufen double-stranded RNA binding protein 1 (STAU1) is remarkably downregulated in the GIGYF2-depleted ECs. STAU1 depletion significantly attenuated GIGYF2-induced cellular senescence, dysfunction, and inflammation in young ECs. Furthermore, we disclosed that GIGYF2 acting as an RNA binding protein (RBP) enhances STAU1 mRNA stability, and that the intron region of the late endosomal/lysosomal adaptor MAPK and mTOR activator 4 (LAMTOR4) could bind to STAU1 protein to upregulate LAMTOR4 expression. Immunofluorescence staining showed that GIGYF2 overexpression promoted the translocation of mTORC1 to lysosome. In the mice model, GIGYF2flox/flox Cdh-Cre+ mice protected aged mice from aging-associated vascular endothelium-dependent relaxation and arterial stiffness. Our work discloses that GIGYF2 serving as an RBP enhances the mRNA stability of STAU1 that upregulates LAMTOR4 expression through binding with its intron region, which activates the mTORC1-S6K1 signaling via recruitment of mTORC1 to the lysosomal membrane, ultimately leading to ECs senescence, dysfunction, and vascular aging. Disrupting the GIGYF2-STAU1-mTORC1 signaling cascade may represent a promising therapeutic approach against vascular aging and aging-related cardiovascular diseases.

Strong interface coupling boosting hierarchical bismuth embedded carbon hybrid for high-performance capacitive deionization.

Capacitive deionization (CDI) is regarded as a promising desalination technology owing to its low cost and environmental friendliness. However, the lack of high-performance electrode materials remains a challenge in CDI. Herein, the hierarchical bismuth-embedded carbon (Bi@C) hybrid with strong interface coupling was prepared through facile solvothermal and annealing strategy. The hierarchical structure with strong interface coupling between the bismuth and carbon matrix afforded abundant active sites for chloridion (Cl-) capture, improved electrons/ions transfer and the stability of the Bi@C hybrid. As a result of these advantages, the Bi@C hybrid showed a high salt adsorption capacity (75.3 mg/g under 1.2 V), salt adsorption rate and good stability, making it a promising electrode material for CDI. Furthermore, the desalination mechanism of the Bi@C hybrid was elucidated through various characterizations. Therefore, this work provides valuable insights for the design of high-performance bismuth-based electrode materials for CDI.

Role variations of MnOx on monoclinic BiVO4 (110)/(040) facets for enhanced Photo-Fenton reactions.

Compared with traditional Fenton reaction, peroxymonosulfate based advanced oxidation processes (PMS-AOPs) are more effective to remove the organic pollutants in wastewater in a wider pH range. Herein, selective loading of MnOx on monoclinic BiVO4 (110) or (040) facets were achieved by photo-deposition method with addition of different Mn precursors and electron/hole trapping agents. MnOx has good chemical catalysis activity for PMS activation, which can also enhance photogenerated charge separation, thus leading to enhanced activities than naked BiVO4. The BPA degradation reaction rate constants of MnOx(040)/BiVO4 and MnOx(110)/BiVO4 system are 0.245 min-1 and 0.116 min-1, which are 6.45 and 3.05 times larger than that of naked BiVO4, respectively. The roles of MnOx on different facets are different, which will promote OER process on (110) facets and utilize the dissolved O2 to produce O2•- and 1O2 more effectively on (040) facets. 1O2 is the dominated reactive oxidation species of MnOx(040)/BiVO4, while SO4•- and •OH play more important roles on MnOx(110)/BiVO4, which are proved by quenching experiments and chemical probe identifications, thus mechanism in MnOx/BiVO4-PMS-light system is proposed. The good degradation performance of MnOx(110)/BiVO4 and MnOx(040)/BiVO4 and mechanism theory may promote the application of photocatalysis in PMS based wastewater remediation.

Tunable Pt-Ni Interaction Induced Construction of Disparate Atomically Dispersed Pt Sites for Acidic Hydrogen Evolution.

Developing cost-effective Pt-based electrocatalysts for the hydrogen evolution reaction (HER) is highly urgent. Herein, we report novel electrocatalysts with individually dispersed Pt active sites and tunable Pt-Ni interaction decorated on carbon-wrapped nanotube frameworks (Pt/Ni-DA). Pt/Ni-DA exhibits superior HER performance at low Pt concentrations with an ultralow overpotential of 18 mV at 10 mA cm-2 and an ultrahigh mass activity of 2.13 A mgPt-1 at an overpotential of 50 mV, which is about four times higher than that of commercial Pt/C. X-ray absorption fine structure (XAFS) confirms the extension of Pt from the Ni surface to the Ni bulk phase. Mechanistic research and density functional theory (DFT) calculations collectively reveal that the dispersibility and distribution of Pt atoms in Ni regulate the electronic configuration of Pt sites, optimizing the binding energy of reaction intermediates and facilitating electron transfer during the HER process. This work highlights the importance of the electronic structure alternation through the accommodation effect toward enhanced catalytic performance in HER.

Enhanced redox cycle of Fe3+/Fe2+ on Fe@NC by boron: Fast electron transfer and long-term stability for Fenton-like reaction.

In this work, Fe@NC/B material is successfully synthesized and in-situ supported on the surface of amorphous boron (B) using a simple pyrolysis method. The interface between Fe species and B is improved by introducing N-doped carbon (NC) layers as intermediate, fast electron transfer from B to Fe@NC can therefore be achieved, thus could promote the fast redox cycle of Fe3+/Fe2+. The obtained material can therefore activate peroxymonosulfate (PMS) effectively to degrade Bisphenol A (BPA), a fast degradation rate and a very long lifetime in a continous tubular reactor are realized. Moreover, experiments and DFT calculation indicate that Fe2+ containing species are the dominated active sites, while the exposed B atoms and structure defect of B can also activate PMS directly to produce SO4•- and 1O2 species for BPA degradation. In addition, boric acid is the oxidation product of B, which can be dissolved into the aqueous solution and expose fresh B species again for PMS activation. The combination of B with Fe@NC provide novel materials for long term PMS activation, thus could promote the real application of persulfates on an industrial scale.

Facile and effective defect engineering strategy boosting ammonium vanadate nanoribbon for high performance aqueous zinc-ion batteries.

Vanadium-based oxides have gained widespread attention as promising cathode materials for aqueous zinc-ion batteries (AZIBs) due to their abundant valences, high theoretical capacity and low cost. However, the intrinsic sluggish kinetics and unsatisfactory conductivity have severely hampered their further development. Herein, a facile and effective defect engineering strategy was developed at room temperature to prepare the defective (NH4)2V10O25·8H2O (d-NHVO) nanoribbon with plenty of oxygen vacancies. Owing to the introduction of oxygen vacancies, the d-NHVO nanoribbon possessed more active sites, excellent electronic conductivity and fast ion diffusion kinetics. Benefiting from these advantages, the d-NHVO nanoribbon as an aqueous zinc-ion battery cathode material exhibited superior specific capacity (512 mAh g-1 at 0.3 A g-1), excellent rate capability and long-term cycle performance. Simultaneously, the storage mechanism of the d-NHVO nanoribbon was clarified via comprehensive characterizations. Furthermore, the pouch battery based on the d-NHVO nanoribbon was fabricated and presented eminent flexibility and feasibility. This work provides a novel thought for simple and efficient development of high- performance vanadium-based oxides cathode materials for AZIBs.

Electro-reduction induced fast metal redox cycle on Co3O4-CuO@CNTs/Copper foam cathode for enhanced Fenton-like reaction.

In this study, free-standing Co3O4-CuO/CF electrodes are synthesized via an electrodeposition-annealing process and then protected by dip-coated carbon nanotubes (CNTs). The obtained Co3O4-CuO@CNTs/CF is employed as cathode to activate peroxymonosulfate (PMS) for the degradation of Bisphenol A (BPA) in an electrochemical system. The electrochemical assistant (EA) plays a critical role to accelerate metal redox by donating electrons sustainably, and the fast regeneration of Co2+/Cu+ could be achieved to promote chemical-catalysis for PMS activation, which is proved via the pre-electroreduction treatment. The rate constant of Co3O4-CuO@CNTs/CF/PMS system with EA is âˆ¼ 4.4 times compared to the system without EA. It also exhibits an excellent stability, which could still remove over 90% of BPA after eight cycles in 45 min. In addition, the coating of CNTs could decrease leaching of metals effectively. According to quenching tests and electron spin-resonance spectroscopy (ESR), the presence of EA could enhance the radical route by producing more SO4•- and •OH greatly, which is also proved by much faster degradation of carbamazepine (CBZ) and atrazine (ATZ) than that without EA. This work reveals activation mechanism of PMS in the electrochemical system, and provides an effective strategy to achieve the fast metal redox cycle for effective and long-term pollutant degradation.

Complete reconstruction of NiMoO4/NiFe LDH for enhanced oxygen evolution reaction.

The oxygen evolution reaction (OER) is a vital half-reaction in several electrochemical energy conversion devices. Herein, we report a hierarchical NiMoO4/NiFe LDH pre-catalyst that enables complete reconstruction and fine structural inheritance, while exhibiting a low overpotential of 188 mV at 10 mA cm-2 in 1.0 M KOH.

Vertically Aligned Bismuthene Nanosheets on MXene for High-Performance Capacitive Deionization.

Capacitive deionization has been considered as a promising solution to the challenge of freshwater shortage due to its high efficiency, low environmental footprint, and low energy consumption. However, developing advanced electrode materials to improve capacitive deionization performance remains a challenge. Herein, the hierarchical bismuthene nanosheets (Bi-ene NSs)@MXene heterostructure was successfully prepared by combining the Lewis acidic molten salt etching and the galvanic replacement reaction, which achieves the effective utilization of the molten salt etching byproducts (residual copper). The vertically aligned bismuthene nanosheets array evenly in situ grown on the surface of MXene, which not only facilitate ion and electron transport as well as offer abundant active sites but also provide strong interfacial interaction between bismuthene and MXene. Benefiting from the above advantages, the Bi-ene NSs@MXene heterostructure as a promising capacitive deionization electrode material exhibits high desalination capacity (88.2 mg/g at 1.2 V), fast desalination rate, and good long-term cycling performance. Moreover, the mechanisms involved were elaborated by systematical characterizations and density functional theory calculations. This work provides inspirations for the preparation of MXene-based heterostructures and their application for capacitive deionization.

Stability enhancing of perovskite LaCoO3 by compositing with oxygen doped MoS2 in Fenton-like reactions.

Perovskite materials are reported to be effective in peroxymonosulfate (PMS) based Fenton-like reactions, the leaching rates of chalcogenide materials in perovskite materials are however serious, thus leading to bad performance in long-term stability. In this study, an O-doped MoS2 is synthesized to composite with LaCoO3, and the high catalytic activity of LaCoO3 is well preserved with greatly decreased Co leaching. During the BPA degradation with PMS as oxidant, ∼100% degradation can be achieved in 20 min and this degradation efficiency can be maintained for ∼45 h in a simulated fixed bed reactor, which is almost 3 times longer than the pure LaCoO3. With the compositing of O-doped MoS2, the leached Co was greatly decreased and the dominated reactive oxidation species (ROS) transformed from SO4•- into O2•- with longer lifespan, thus resulting in the better stability. This study could promote the application of perovskite materials in the real industrial wastewater treatment.

ETNPPL modulates hyperinsulinemia-induced insulin resistance through the SIK1/ROS-mediated inactivation of the PI3K/AKT signaling pathway in hepatocytes.

Hyperinsulinemia is a critical risk factor for the pathogenesis of insulin resistance (IR) in metabolic tissues, including the liver. Ethanolamine phosphate phospholyase (ETNPPL), a newly discovered metabolic enzyme that converts phosphoethanolamine (PEA) to ammonia, inorganic phosphate, and acetaldehyde, is abundantly expressed in liver tissue. Whether it plays a role in the regulation of hyperinsulinemia-induced IR in hepatocytes remains elusive. Here, we established an in vitro hyperinsulinemia-induced IR model in the HepG2 human liver cancer cell line and primary mouse hepatocyte via a high dose of insulin treatment. Next, we overexpressed ETNPPL by using lentivirus-mediated ectopic to investigate the effects of ETNPPL per se on IR without insulin stimulation. To explore the underlying mechanism of ETNPPL mediating hyperinsulinemia-induced IR in HepG2, we performed genome-wide transcriptional analysis using RNA sequencing (RNA-seq) to identify the downstream target gene of ETNPPL. The results showed that ETNPPL expression levels in both mRNA and protein were significantly upregulated in hyperinsulinemia-induced IR in HepG2 and primary mouse hepatocytes. Upon silencing ETNPPL, hyperinsulinemia-induced IR was ameliorated. Under normal conditions without IR in hepatocytes, overexpressing ETNPPL promotes IR, reactive oxygen species (ROS) generation, and AKT inactivation. Transcriptome analysis revealed that salt-inducible kinase 1 (SIK1) is markedly downregulated in the ETNPPL knockdown HepG2 cells. Moreover, disrupting SIK1 prevents ETNPPL-induced ROS accumulation, damage to the PI3K/AKT pathway and IR. Our study reveals that ETNPPL mediates hyperinsulinemia-induced IR through the SIK1/ROS-mediated inactivation of the PI3K/AKT signaling pathway in hepatocyte cells. Targeting ETNPPL may present a potential strategy for hyperinsulinemia-associated metabolic disorders such as type 2 diabetes.

ETNPPL impairs autophagy through regulation of the ARG2-ROS signaling axis, contributing to palmitic acid-induced hepatic insulin resistance.

Excessive free fatty acids (FFAs) accumulation is a leading risk factor for the pathogenesis of insulin resistance (IR) in metabolic tissues, including the liver. Ethanolamine-phosphate phospho-lyase (ETNPPL), a newly identified metabolic enzyme, catalyzes phosphoethanolamine (PEA) to ammonia, inorganic phosphate, and acetaldehyde and is highly expressed in hepatic tissue. Whether it plays a role in regulating FFA-induced IR in hepatocytes has yet to be understood. In this study, we established an in vitro palmitic acid (PA)-induced IR model in human HepG2 cells and mouse AML12 cells with chronic treatment of PA. Next, we overexpressed ETNPPL by using lentivirus-mediated ectopic to investigate the effects of ETNPPL per se on IR without PA stimulation. We show that ETNPPL expression is significantly elevated in PA-induced IR and that silencing ETNPPL ameliorates this IR in hepatocytes. Inversely, overexpressing ETNPPL under normal conditions without PA promotes IR, reactive oxygen species generation, and ARG2 activation in both HepG2 and AML12 cells. Moreover, ETNPPL depletion markedly down-regulates ARG2 expression in hepatocytes. Besides, silencing ARG2 prevents ETNPPL-induced ROS accumulation and inhibition of autophagic flux and IR in hepatocytes. Finally, we found that phytopharmaceutical disruption of ETNPPL by quercetin ameliorates PA-induced IR in hepatocytes. Our study discloses that ETNPPL inhibiting autophagic flux mediates insulin resistance triggered by PA in hepatocytes via ARG2/ROS signaling cascade. Our findings provide novel insights into elucidating the pathogenesis of obesity-associated hepatic IR, suggesting that targeting ETNPPL might represent a potential approach for T2DM therapy.