1.
Bioorg Med Chem Lett
; 25(11): 2314-20, 2015 Jun 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25937011
RESUMO
Novel, mesalazine, metronidazole conjugates 6a-e with amino acid linkers were synthesized utilizing benzotriazole chemistry. Biological data acquired for all the novel bis-conjugates showed (a) some bis-conjugates exhibit comparable anti-inflammatory activity with parent drugs and (b) the potent bis-conjugates show no visible stomach lesions. 3D-pharmacophore and 2D-QSAR modeling support the observed bio-properties.