Delta-alpha/beta coupling as a signature of visual working memory in the prefrontal cortex.

Executive functions, particularly visual working memory, depend on the prefrontal cortex (PFC). Phase-amplitude coupling (PAC) has been proposed as a measure of synchronized brain oscillations. To study the neural correlates of working memory in cross-frequency interactions, local field potential (LFP) recordings were made in the PFC of two macaque monkeys. PAC analysis revealed that the delta band (1-5 Hz) phase modulated the alpha-beta band (8-33 Hz) amplitude throughout task epochs, in both the pre- and post-training stages. The elevation of δ-αß PAC in the fixation period during post-training was a signature of task learning. Interestingly, the δ-αß PAC was not enhanced in error trials compared to correct trials, and the subject's performance was strictly dependent on the orchestration of the delta phase. Furthermore, contrary to the dorsoventral functional specialization of PFC, spatial and shape stimuli induced the same pattern of PAC in PFC subdivisions.

Small Urban Green Spaces: Insights into Perception, Preference, and Psychological Well-being in a Densely Populated Areas of Tehran, Iran.

In metropolitan areas worldwide, abandoned properties are prevalent, prompting a need for small urban green spaces (SUGS) to meet the growing demand. Understanding residents' preferences and perceptions of transformed spaces is vital for effective urban design. This study delves into residents' preferences and perceptions regarding the transformation of such spaces into SUGS and their impact on psychological well-being. By examining how these preferences and perceived health benefits shape the value of transformed spaces, the research aims to inform effective urban design strategies. The participants underwent visual stimulation, with psychological reactions recorded through Electroencephalogram (EEG) readings and assessed via Questionnaire. Machine learning techniques analyzed EEG sub-band data, achieving an average accuracy of 92.8% when comparing leftover and designed spaces. Results revealed that different types of transformed spaces provoke distinct physiological and preference responses. Specifically, viewing SUGS was associated with significant changes in gamma wave power, suggesting a correlation between enhanced gamma activity and increased feelings of empathy. Moreover, participants also reported enhanced comfort, relaxation, and overall mood, and a strong preference for SUGS over untransformed spaces, emphasizing the value placed on these areas for their health benefits. This research highlights the positive impact of even SUGS on mental health, using EEG data to assess emotional states triggered by urban spaces. The study concludes with a call for further research to investigate the long-term benefits of SUGS on well-being, alongside an exploration of the gamma band as a neural marker for emotional restoration in urban green spaces. This research highlights the crucial role of urban design in fostering psychological well-being through the strategic development of green spaces, suggesting a paradigm shift toward more inclusive, health-promoting urban environments.

Dynamic theta-modulated high frequency oscillations in rat medial prefrontal cortex during spatial working memory task.

Interaction of oscillatory rhythms at different frequencies is considered to provide a neuronal mechanism for information processing and transmission. These interactions have been suggested to have a vital role in cognitive functions such as working memory and decision-making. Here, we investigated the medial prefrontal cortex (mPFC), which is known to have a critical role in successful execution of spatial working memory tasks. We recorded local field potential oscillations from mPFC while rats performed a delayed-non-match-to-place (DNMTP) task. In the DNMTP task, the rat needed to decide actively about the pathway based on the information remembered in the first phase of each trial. Our analysis revealed a dynamic phase-amplitude coupling (PAC) between theta and high frequency oscillations (HFOs). This dynamic coupling emerged near the turning point and diminished afterward. Further, theta activity during the delay period, which is thought of as the maintenance phase, in the absence of the coupling, can predict task completion time. We previously reported diminished rat performance in the DNMTP task in response to electromagnetic radiation. Here, we report an increase in the theta rhythm during delay activity besides diminishing the coupling after electromagnetic radiation. These findings suggest that the different roles of the mPFC in working memory could be supported by separate mechanisms: Theta activity during the delay period for information maintenance and theta-HFOs phase-amplitude coupling relating to the decision-making procedure.

Investigating the impact of mobile range electromagnetic radiation on the medial prefrontal cortex of the rat during working memory.

Research has been focused on the effects of radiofrequency electromagnetic radiation (RF-EMR) emitted from a mobile phone on general health, especially the nervous system. The purpose of this study was to investigate the impact of RF-EMR on the brain mechanism of rats by recording local field potentials (LFPs) signals during working memory (WM) task. Subjects were exposed to 900 MHz from a dipole antenna daily for three hours. Exposure was applied, first on a short term base (1 week) and then on a long term base (4 weeks). Behavioral parameters were measured weekly while rats performed T-maze tasks in two types of normal and delayed. LFPs signals were simultaneously recorded by implanted microelectrode arrays on the medial prefrontal cortex (mPFC) of rats. Results showed a significant increase (*p < 0.05) in the task completion time of exposed rats which vanished shortly after the end of short term RF-EMR exposure. Before exposure, during correctly performed delayed tasks, an increase (peak) in power changes of theta band (4-12 Hz) was observed. But during correctly performed normal tasks, an increase appeared only by applying RF-EMR exposure. The similarity in power changes pattern of theta band in both types of tasks was observed after long term exposure. Classification accuracy of LFPs in truly done normal and delayed tasks was compared in pre and post-exposure states. Initial classification accuracy was 84.2 % which decreased significantly (*P < 0.05) after exposure. These observations indicated that RF-EMR may cause unusual brain functioning which is temporary at least for short term exposure.