A state-based probabilistic method for decoding hand position during movement from ECoG signals in non-human primate.

OBJECTIVE: In this study, we proposed a state-based probabilistic method for decoding hand positions during unilateral and bilateral movements using the ECoG signals recorded from the brain of Rhesus monkey. APPROACH: A customized electrode array was implanted subdurally in the right hemisphere of the brain covering from the primary motor cortex to the frontal cortex. Three different experimental paradigms were considered: ipsilateral, contralateral, and bilateral movements. During unilateral movement, the monkey was trained to get food with one hand, while during bilateral movement, the monkey used its left and right hands alternately to get food. To estimate the hand positions, a state-based probabilistic method was introduced which was based on the conditional probability of the hand movement state (i.e. idle, right hand movement, and left hand movement) and the conditional expectation of the hand position for each state. Moreover, a hybrid feature extraction method based on linear discriminant analysis and partial least squares (PLS) was introduced. MAIN RESULTS: The proposed method could successfully decode the hand positions during ipsilateral, contralateral, and bilateral movements and significantly improved the decoding performance compared to the conventional Kalman and PLS regression methods [Formula: see text]. The proposed hybrid feature extraction method was found to outperform both the PLS and PCA methods [Formula: see text]. Investigating the kinematic information of each frequency band shows that more informative frequency bands were [Formula: see text] (15-30 Hz) and [Formula: see text](50-100 Hz) for ipsilateral and [Formula: see text] and [Formula: see text] (100-200 Hz) for contralateral movements. It is observed that ipsilateral movement was decoded better than contralateral movement for [Formula: see text] (5-15 Hz) and [Formula: see text] bands, while contralateral movements was decoded better for [Formula: see text] (30-200 Hz) and hfECoG (200-400 Hz) bands. SIGNIFICANCE: Accurate decoding the bilateral movement using the ECoG recorded from one brain hemisphere is an important issue toward real-life applications of the brain-machine interface technologies.

A piecewise probabilistic regression model to decode hand movement trajectories from epidural and subdural ECoG signals.

OBJECTIVE: The primary concern of this study is to develop a probabilistic regression method that would improve the decoding of the hand movement trajectories from epidural ECoG as well as from subdural ECoG signals. APPROACH: The model is characterized by the conditional expectation of the hand position given the ECoG signals. The conditional expectation of the hand position is then modeled by a linear combination of the conditional probability density functions defined for each segment of the movement. Moreover, a spatial linear filter is proposed for reducing the dimension of the feature space. The spatial linear filter is applied to each frequency band of the ECoG signals and extract the features with highest decoding performance. MAIN RESULTS: For evaluating the proposed method, a dataset including 28 ECoG recordings from four adult Japanese macaques is used. The results show that the proposed decoding method outperforms the results with respect to the state of the art methods using this dataset. The relative kinematic information of each frequency band is also investigated using mutual information and decoding performance. The decoding performance shows that the best performance was obtained for high gamma bands from 50 to 200 Hz as well as high frequency ECoG band from 200 to 400 Hz for subdural recordings. However, the decoding performance was decreased for these frequency bands using epidural recordings. The mutual information shows that, on average, the high gamma band from 50 to 200 Hz and high frequency ECoG band from 200 to 400 Hz contain significantly more information than the average of the rest of the frequency bands [Formula: see text] for both subdural and epidural recordings. The results of high resolution time-frequency analysis show that ERD/ERS patterns in all frequency bands could reveal the dynamics of the ECoG responses during the movement. The onset and offset of the movement can be clearly identified by the ERD/ERS patterns. SIGNIFICANCE: Reliable decoding the kinematic information from the brain signals paves the way for robust control of external devices.