Breast carcinoma in children and adolescents.

Seventy-four cases of breast cancer in children and adolescents are reviewed. No predisposing factors were identified. A secretory type of mammary carcinoma characteristically seen in this age group has an excellent prognosis. Other types of mammary carcinoma which also occur in children may have a less favorable prognosis. Persistent breast masses in children and adolescents should be biopsied unless cystic, and should be treated as would carcinoma in adults, keeping in mind the favorable prognosis in so-called secretory carcinoma.

Effects of dialyzable transfer factor in patients with breast cancer.

Five patients with advanced breast cancer were treated with pooled dialyzable transfer factor from healthy adult donors. The period of treatment ranged from 21 to 310 days, the total dose from 20 to 257 ml. Transfer factor did not elicit inflammatory or hypersensitivity reactions or detectable formation of antibody to itself, nor any hematological or biochemical abnormalities or other side effects. Three patients became responsive (by skin test) to tuberculin and/or streptococcal antigens. Marked partial regression of the breast cancer, lasting 6 months, was observed in one patient.