RESUMO
Results of treatment of 229 patients, suffering an acute necrotic pancreatitis, complicated by peripancreatic infiltrate, were analyzed. To all the patients antibiotic prophylaxis and antibiotic therapy were conducted. In 63 (27.5%) patients the methods of extracorporal hemocorrection were applied, and in 108 (47.1%)--the "four--catheters" rule (catheter for epidural anesthesia, installment of the feeding intestinal probe further than the Treitz ligament level, the central vein catheterization, the programmed laparocentesis). In 31 (13.5%) patients there were determined the activity of mononuclear phagocytes and production of ROS (the oxygen active forms) by them in peripheral blood with objective for the purulent-septic complications prognostication. In 14 (6.1%) patients purulent--septic complications have occurred, postoperative lethality was 21.4%, general lethality--3.4%.
Assuntos
Antibacterianos/uso terapêutico , Pancreatite Necrosante Aguda/diagnóstico , Pancreatite Necrosante Aguda/terapia , Sepse/diagnóstico , Sepse/terapia , Adulto , Líquido Ascítico/efeitos dos fármacos , Cateteres de Demora , Feminino , Hemoperfusão , Humanos , Leucócitos Mononucleares/efeitos dos fármacos , Leucócitos Mononucleares/metabolismo , Leucócitos Mononucleares/patologia , Masculino , Pessoa de Meia-Idade , Pancreatite Necrosante Aguda/complicações , Pancreatite Necrosante Aguda/mortalidade , Prognóstico , Espécies Reativas de Oxigênio/metabolismo , Sepse/etiologia , Sepse/mortalidade , Análise de Sobrevida , Resultado do TratamentoRESUMO
Tumour-associated macrophages (TAM) make about 80% a total stromal leucocytes in solid tumours. Phenotypic and functional plasticity of this cell population causes its dual effect on tumour grows. Exceptional role of TAM in tumour progression makes them an attractive targets for selective cancer therapy. In this review the main groups of TAM-oriented methods of cancer therapy directed on inhibition of tumour angiogenesis and reactivation of antitumour action of TAM are analysed.