[HYGIENIC SUBSTANTIATION OF THE DEVELOPMENT AND USE OF POLYGUANIDINES AS ANTIMICROBIAL PROPHYLACTIC MEANS OF THE INNOVATIVE CLASS].

In the article there are presented data of the system analysis of hygienic properties of polyguanidines (PAG) as an innovative class of domestic microbicidal chemical long-acting compounds synthesized in the domestic scientific institution--Institute ofenvironmental and technological problems, and also delivered on their base new disinfectants. Submitted proceedings of microbiological studies indicate to the antimicrobial action of PA G against Gram-negative and Gram-positive bacteria, viruses, dermatophytes, yeasts, fungi, including pathogens, as well infectious agent of swine and legionellosis. The data of toxicological studies of PAG and a number of derivative disinfectants justify their hygienic safety in dependence on the chemical nature of the used anion (A), the composition and structure of the polymer chain and also the content of residual monomers. All this characterizes PAG as a very promising group of compounds for the use in the form of independent disinfectants and as antimicrobial additives and auxiliaries in such means for different purposes.

[Methodology for evaluation of disinfectants on the basis of system analysis]. / Metodologiia kompleksnoi otsenki dezinfitsiruiushchikh sredstv na osnove sistemnogo analiza.

The paper proposes a methodology based on the operation study theory, which can compare disinfectants by a combination of all their properties, which is integrated in the cost of tackling a disinfectological task rather than by the presence or magnitude of these or those useful properties.

[Gas-chromatographic analysis of hypercholestanol in the bile and its role in the pathogenesis of cholelithiasis]. / Gazozhidkostno-khromatograficheskoe opredelenie giperkholestanol- kholii i ee znacheniev patogeneze kholelitiaza.

The cholestanol/cholesterol ratio in the bladder and liver bile was estimated by capillary gas-liquid chromatography in patients with dyskinesia of the gallbladder, chronic acalculous cholecystitis, and chronic calculous cholecystitis. Cholesterol biliary calculi and their surface and intermediate layers and the core were examined either. The authors came to a conclusion that cholestanol/cholesterol ratio in the bladder and liver bile reflected the progress of liver cholesterol metabolism starting from the early stages of cholelithiasis to the formation of cholesterol biliary calculi. Therefore hypercholestanolcholia should be considered as an indicator of the risk of cholesterol biliary calculi development.

[Nervous tissue glycoproteins normally and under the action of oxygen under pressure]. / Glikoproteidy nervnoi tkani v norme i pri vozdeistvii kisloroda pod davleniem

Salt-soluble proteins of great hemispheres of rats, intact and those subjected to the effect of hyperbarooxigenation, were separated by DEAE-cellulose chromatography into 10 heterogenous fractions, each of them containing 5-12 subfractions. The content of glucosamine and sialic acid was determined in each of the isolated fractions. Changes in the degree of heterogeneity and in total content of protein in the fractions as well as variations in the content of carbohydrate components in the chromatographic fractions are observed under the effect of hyperoxia.