RESUMO
The clock gene Rev-erbα, also known as nuclear receptor subfamily 1 group D member 1 (Nr1d1), is a crucial regulatory factor in organisms. It exhibits circadian rhythmic expression in metabolically active tissues such as skeletal muscles, heart, liver, and adipose tissue, responding to various environmental stimuli. Rev-erbα plays a significant role in regulating circadian rhythms, metabolic homeostasis, and other physiological processes, earning its designation as an “integrator” of the circadian system and metabolism. Rev-erbα establishes complex connections with other clock genes through the transcriptional-translational feedback loop (TTFL), which is important for the rhythmic output of biological clock system and for the relative stability of phases and cycles. Mitochondrial biogenesis is a physiological process initiated by cells to maintain energy homeostasis by using existing mitochondria as a template for self-growth and division. As the “energy factory” of organism, disruptions in mitochondrial biogenesis are closely associated with the development of various diseases. Studies have shown that not only the factors involved in mitochondrial biogenesis have circadian oscillations, but also the morphology, dynamics and energy metabolism of mitochondria themselves have cyclic fluctuations throughout the day, suggesting that mitochondrial biogenesis is regulated by the biological clock system, in which the clock gene Rev-erbα plays a key role, it drives mitochondrial biogenesis and synergistically regulates autophagy to normalize a number of physiological processes in the body. Rev-erbα is sensitive to both internal and external environmental changes, and disruptions in circadian rhythms, metabolic diseases, and aging are significant inducers of changes in Rev-erbα expression, and its concomitant inflammation and oxidative stress may be an intrinsic mechanism for inhibiting mitochondrial biogenesis. Therefore, the enhancement of mitochondrial biogenesis by regulating the Rev-erbα activity status may be an important way to improve the pathology and promote the health of organism. Exercise, as a commonly accepted non-pharmacological tool, plays an important role in enhancing mitochondrial biogenesis and promoting health. It has been found that there is a close relationship between exercise and Rev-erbα. On the one hand, exercise stimulation directly affects the expression of Rev-erbα, especially high-intensity and long-term regular exercise; on the other hand, Rev-erbα achieves indirect regulation of exercise capacity by mediating processes such as skeletal muscle mitochondrial biogenesis and autophagy, muscle mass maintenance, energy metabolism and skeletal muscle regeneration. Based on the above findings, it is hypothesized that Rev-erbα may serve as a key bridge between exercise and mitochondrial biogenesis. Exercise enhances the transcriptional response of Rev-erbα in the nucleus, upregulates the expression of Rev-erbα protein in cytoplasm, activates the AMP-activated proteinkinase (AMPK)/ silent information regulator 1 (SIRT1)/peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) pathway, regulates Ca2+ flux and downstream signaling molecules; meanwhile, exercise can upregulate antioxidant gene expression and alleviate oxidative stress through Rev-erbα, which ultimately enhances the function of mitochondria, and promotes mitochondrial biogenesis. In conclusion, the clock gene Rev-erbα emerges as a crucial target for exercise-induced enhancement of mitochondrial biogenesis. In this paper, the biological characteristics ofRev-erbα, the role of Rev-erbα in regulating mitochondrial biogenesis and the factors that may influence it, the interaction between exercise and Rev-erbα, and the potential mechanism of exercise-induced mitochondrial biogenesis via Rev-erbα are sorted out and discussed, which can provide theoretical references to the mechanism of exercise-promoted mitochondrial biogenesis.
RESUMO
Nanostructures provide a simple, effective, and low-cost route to enhance the light-trapping capability of optoelectronic devices. In recent years, nano-optical structures have been widely used in perovskite optoelectronic devices to greatly enhance the device performance. However, the inherent instability of perovskite materials hinders the practical application of these nanostructured optoelectronic devices. Here, in situ encapsulated moiré lattice perovskite photodetectors (PDs) by two nanograting-structured soft templates with relative rotation angles is fabricated. The confinement growth of the two nanograting templates leads to crystal growth with moiré lattice structure, which improves the light-harvesting ability of the perovskite crystal, thereby improving the device performance. The PD exhibits responsivity to 1026.5 A W-1 . The Moiré lattice-perovskite-based PD maintained 95% of the initial performance after 223 days. After being continuously sprayed with water moist for 180 min, the performance is maintained at 95.7% of its initial level. The nanograting structure endows the device with high polarization sensitivity of Imax /Imin as high as 9.1.
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The consumption of energy is an important resource that cannot be ignored in modern society. Non-renewable forms of energy, such as coal, natural gas, and oil, have always been important strategic resources and are always facing a crisis of shortage. Therefore, there is an urgent need for green renewable forms of energy. As an emerging green energy source, the moist-electric generator (MEG) has been studied in recent years and may become an energy source that can be utilized in daily life. Along with the advancement of technological means, nanoarchitectonics play an important role in MEG devices. This review aims to provide a comprehensive summary of the fundamentals of the MEG from the perspective of different material classifications and to provide guidance for future work in the field of MEGs. The effects of various parameters and structural designs on the output power, recent important literature and works, the mechanism of liquid-solid interactions at the nanoscale, and the application status and further potential of MEG devices are discussed in this review. It is expected that this review may provide valuable knowledge for future MEG research.
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As an important indicator of phytoplankton biomass in lakes, the chlorophyll-a (Chl-a) concentration reflects the abundance and variation of phytoplankton in the water. Based on the monthly monitoring data of Chl-a and environmental factors in Lake Taihu from December 1999 to August 2019, key environmental factors related to Chl-a and their relationships were found using the principal component analysis (PCA) method. A multiple linear stepwise regression model and an auto-regressive integrated moving average (ARIMA) model were developed to predict the monthly Chl-a concentrations. The results showed that the Chl-a concentrations in Lake Taihu exhibited clear seasonal change characteristics and an overall trend of a gradual increase. The changes in total phosphorus (TP), the permanganate index, monthly average temperature (MAT), and monthly rainfall (MR) matched the Chl-a concentrations relatively well, whereas the changes in total nitrogen (TN) and ammonium nitrogen (NH4+-N) lagged significantly. The PCA results showed that the increased phytoplankton biomass and consequent algae outbreaks in Lake Taihu were not limited to the effect of a single factor such as TN or TP, but were comprehensively affected by multiple factors such as TN, NH4+-N, TP, the permanganate index, MR, and MAT. Through further validation, the ARIMA model of Chl-a concentrations was proved to be significantly better than the multiple linear stepwise regression model, especially when considering the key environmental factors as independent variables and optimizing their values. The established ARIMA (0,1,1) (0,1,1) model would be helpful for forecasting algae blooms in Lake Taihu and provide useful suggestions for water environmental management, such as water resources dispatch and regulation.
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Colorectal mucoceles usually arise in the appendix, and colonic disease is very rare. We report the first case of a mucocele of the colonic liver flexure that was treated successfully with endoscopy. A 36-year-old man was admitted to our hospital because of abdominal distension persisting for 3 days. Colonoscopic examination revealed a round polyp in the hepatic flexure, and we performed hot snare polypectomy with argon plasma coagulation. Histologically, the polypectomy specimen was confirmed to be a mucocele, with no neoplastic changes. Follow-up examinations at 6 and 12 months showed no evidence of recurrence.