Evaluation of antibiotic resistance in Proteus spp: a growing trend that worries Public Health. Results of 10 Years of Analysis.

The genus Proteus includes several species among which Proteus mirabilis is by far the most commonly detected in clinical specimens. In the last twenty years, isolates with multiple acquired resistance genes have been detected, especially in the hospital environment, with a significant impact on the treatment of infections. This research is a ten-year cross-sectional study reporting the detection rates and the antibiotic susceptibility of Proteus spp. in clinical specimens from a healthcare setting in Southern Italy. Of all the 1,600 clinical samples sent to the laboratory, 4.4% were positive to Proteus spp., with P. mirabilis by far the most detected one (83.1%), especially in lower limb ulcers and urines. Moreover, we noted a significant increase of 1200% in the detection rate from 2011 to 2020. Finally, we reported a significant and constantly increasing trend in the detection of antibiotic-resistant strains, ranging from 48.4% in 2011 to 74% in 2020. Our results highlight a clear and significant increase in Proteus spp. detection in a typical hospital setting with a parallel increase in the detection of antibiotic-resistant strains. Therefore, Proteus spp. can be considered one of the main emerging pathogenic bacteria in the hospital environment.

Outcomes of Computer-Assisted Total Knee Arthroplasty Compared to Conventional TKA: A Bicentric Controlled Retrospective Clinical Study.

Despite the globally ascertained success of Total Knee Arthroplasty (TKA) procedure, 20% of patients are still unsatisfied with the surgery results. The purpose of the study is to identify the functional and radiological outcomes of the computer-assisted (CAS) TKA compared to the conventional technique. The clinical databases and medical records of both clinical sites were retrospectively analyzed, and then according to study time-lapse, inclusion, and exclusion criteria, eligible patients were retrieved and included. A total of 42 patients that underwent to CAS TKA (NAVI) and 61 patients that underwent to Conventional TKA (CONV) were included. The NAVI group reported a statistically significant higher surgical time. A lower intraoperative blood loss was found in the computer-assisted group, though this difference was not statistically significant. Implant survival analysis at two years did not show differences between groups during the follow-up period. At two years, follow-up postoperative intergroup analysis showed no statistically significant difference between groups. According to the radiologic analysis, the NAVI group showed comparable outcomes to the conventional group. The present study showed that there was no clinical and radiological difference between CAS arthroplasty and conventional technique.