Trombosis de senos venosos cerebrales en una niña con leucemia linfoblástica, portadora de la variante de la protrombina G20210A / Cerebral sinovenous thrombosis in a girl with acute lymphoblastic leukaemia carrying the prothrombin G20210A variant

Aunque la trombosis de senos venosos cerebrales es rara, se asocia con mayor frecuencia en niños con leucemia linfoblástica aguda. Se aporta el caso de una niña de 7 años que desarrolla una trombosis masiva de senos venosos cerebrales en el día 22 del tratamiento de inducción de leucemia linfoblástica aguda de alto riesgo. Clínicamente se manifestaron de forma progresiva cefalea, disminución del nivel de conciencia y hemiplejía izquierda. El estudio de trombofilia posterior reveló heterocigosis para la variante de la protrombina G20210A en la niña y en la madre. Se analizan los factores protrombóticos encontrados en el caso antes y después de la trombosis. Se confirma la importancia de investigar precozmente tanto los factores de riesgo de trombosis adquiridos como los estados de trombofilia primaria en niños con leucemia linfoblástica. Esta estrategia podría ayudar a identificar a pacientes de especial riesgo e instaurar en ellos tromboprofilaxis(AU)

Although cerebral venous thrombosis is rare, it is more commonly associated with children suffering from acute lymphoblastic leukaemia. We report the case of a 7-year-old girl who developed massive cerebral sinovenous thrombosis on day 22 of induction therapy for high-risk acute lymphoblastic leukaemia. Clinical symptoms were gradual onset of headache, decreasing consciousness, and ensuing left hemiplegia. A subsequent prothrombotic study revealed a heterozygous prothrombin G20210A variant in the child and mother. We analysed the prothrombotic factors found in the case before and after thrombosis. We confirm the importance of early exploration of patients for clinical predisposing risk factors of thrombosis and primary prothrombotic states in children with acute lymphoblastic leukaemia. This might help identify patients at particular risk from thrombosis and so administer thromboprophylaxis(AU)

[Cerebral sinovenous thrombosis in a girl with acute lymphoblastic leukaemia carrying the prothrombin G20210A variant]. / Trombosis de senos venosos cerebrales en una niña con leucemia linfoblástica, portadora de la variante de la protrombina G20210A.

Although cerebral venous thrombosis is rare, it is more commonly associated with children suffering from acute lymphoblastic leukaemia. We report the case of a 7-year-old girl who developed massive cerebral sinovenous thrombosis on day 22 of induction therapy for high-risk acute lymphoblastic leukaemia. Clinical symptoms were gradual onset of headache, decreasing consciousness, and ensuing left hemiplegia. A subsequent prothrombotic study revealed a heterozygous prothrombin G20210A variant in the child and mother. We analysed the prothrombotic factors found in the case before and after thrombosis. We confirm the importance of early exploration of patients for clinical predisposing risk factors of thrombosis and primary prothrombotic states in children with acute lymphoblastic leukaemia. This might help identify patients at particular risk from thrombosis and so administer thromboprophylaxis.