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1.
Acta Otorrinolaringol Esp ; 53(6): 398-404, 2002.
Artigo em Espanhol | MEDLINE | ID: mdl-12402489

RESUMO

In order to investigate the effect of oxidative damage due to free radicals on ENT infectious diseases, levels of superoxide dismutase (SOD), glutathione-peroxidase (GPx) and reductase (GRt) and the total antioxidant status (TAS) were measured by spectrophotometry on tonsillar tissue obtained from tonsillectomy in 538 patients, who were divided in three groups according to their surgical indication: tonsillar hypertrophy (n = 235), recurrent tonsillitis (n = 280) or peritonsillar abscess (n = 23). SOD concentration were also measured on adenoid tissue and middle ear exudate in 75 patients from the first two groups. Erythrocyte and tonsillar SOD levels were significantly greater in the abscess group, and lower in the hypertrophic one. These differences were similar for GPx and TAS. For GRt, its level in abscess were lower than in the other two groups in a statistically significant way. There were strong correlations between erythrocyte and tonsillar SOD, tonsillar SOD and GPx, tonsillar SOD and TAS, and tonsillar GPx and TAS. SOD concentrations from adenoid tissue and middle ear exudate did not affect its blood level. So, we can conclude that tonsillar oxidative damage is determined by the frequency or the severity of local infections, and it can be evaluated by measuring the SOD concentration in the tonsillar tissue or in the peripheral blood. So, it can be considered a good marker of tonsillar damage.


Assuntos
Glutationa Peroxidase/análise , Glutationa Redutase/análise , Tonsila Palatina/enzimologia , Superóxido Dismutase/análise , Tonsilite/enzimologia , Tonsila Faríngea/enzimologia , Adolescente , Adulto , Criança , Pré-Escolar , Exsudatos e Transudatos/enzimologia , Feminino , Glutationa Peroxidase/sangue , Glutationa Redutase/sangue , Humanos , Masculino , Especificidade de Órgãos , Otite Média Supurativa/enzimologia , Oxirredução , Estresse Oxidativo , Abscesso Peritonsilar/enzimologia , Recidiva , Superóxido Dismutase/sangue
2.
Acta Otorrinolaringol Esp ; 52(7): 556-64, 2001 Oct.
Artigo em Espanhol | MEDLINE | ID: mdl-11692947

RESUMO

An hemorheological study on whole blood filterability (WBF) was done in eleven patients bearing of sudden deafness, in a continuous way, even before clinical onset. This evaluation is making usually in animal models, but not in humans. Independently of clinical diagnosis of each patient (two cases of diabetes mellitus, one of ulcerative colitis, systemic lupus erythematosus, systemic hypertension, after blood transfusion, sepsis with disseminated intravascular coagulation, upper respiratory ways infection, after surgery, and two healthy individuals), all of them showed a decreased WBF when hearing loss appeared (from 19.97 +/- 1.15 microliters/sec to 16.87 +/- 1.21 microliters/sec). This value normalized at six or seven days from the onset in cases with some kind of hearing recovery (18.83 +/- 1.01 microliters/sec, n = 4), but did not in those with no improvement even at thirty days (17.39 +/- 0.77 microliters/sec, n = 7). There were differences in WBF values of patients with and without hearing recovery in determinations at seven and thirty days from onset. Decrease in WBF accompanies this hearing disorder and confirms the cochlear microcirculation susceptibility to the impairment of blood viscoelastic properties.


Assuntos
Deformação Eritrocítica/fisiologia , Perda Auditiva Súbita/sangue , Adulto , Idoso , Anti-Inflamatórios/uso terapêutico , Feminino , Perda Auditiva Súbita/tratamento farmacológico , Humanos , Masculino , Metilprednisolona/uso terapêutico , Pessoa de Meia-Idade
3.
Acta Otorrinolaringol Esp ; 52(5): 442-5, 2001.
Artigo em Espanhol | MEDLINE | ID: mdl-11526654

RESUMO

Indications for oral anticoagulation and antihistamine H1 antagonists therapies are increasingly. So, it is easy to find individuals who need both treatments. The unknowledgement about possible interferences of antihistamines over acenocumarin often makes to avoid them at the same time. A review on a population receiving anticoagulation on a Therapeutic Center allowed us to verify disorders secondary to the association of antihistamines into their therapeutic scheme. Loratadine, ebastine and cetirizine show similar records of interaction into acenocumarin pharmacokinetics, probably due to a liver enzymatic induction on the anticoagulant drug, producing a decrease on INR values in which anticoagulation is measured. This could make necessary to increase temporally acenocumarin dose. During coadministration no thromboembolic event nor bleeding were registered.


Assuntos
Anticoagulantes/metabolismo , Antagonistas dos Receptores Histamínicos H1/farmacologia , Interações Medicamentosas , Humanos
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