RESUMO
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Assuntos
Humanos , Feminino , Idoso , Doença Relacionada a Imunoglobulina G4/complicações , Derrame Pericárdico/etiologia , Derrame Pleural/etiologia , Tomografia Computadorizada por Raios X , ToracoscopiaRESUMO
El metotrexato es uno de los fármacos más empleados en pacientes con procesos reumatológicos, debido a su eficacia y perfil de seguridad. Sin embargo, los pacientes tratados con este fármaco son en ocasiones de edad avanzada, por lo que el riesgo de toxicidad aumenta, así como el de intoxicación por error en la toma de la medicación. Presentamos el caso de una paciente de 87 años, polimedicada, con antecedentes de deterioro cognitivo y escaso apoyo social que sufrió una intoxicación aguda grave por metotrexato. Además, describimos las características de los casos de toxicidad por este fármaco ingresados en nuestro Hospital en los últimos 7 años
Methotrexate is one of the most widely used drugs in rheumatology due to its high efficacy-to-toxicity. However, patients treated with this drug are sometimes elderly, which increases toxicity risks, as well as mistakes in taking the medication. The case is presented of an 87 year-old patient, on multiple medications, with a history of cognitive impairment and low social support, who suffered acute methotrexate toxicity. A description is also presented on the characteristics of the toxicity cases due this drug admitted to this hospital in the last 7 years
Assuntos
Humanos , Feminino , Idoso de 80 Anos ou mais , Antirreumáticos/intoxicação , Metotrexato/intoxicação , Índice de Gravidade de Doença , Fatores de TempoRESUMO
Methotrexate is one of the most widely used drugs in rheumatology due to its high efficacy-to-toxicity. However, patients treated with this drug are sometimes elderly, which increases toxicity risks, as well as mistakes in taking the medication. The case is presented of an 87 year-old patient, on multiple medications, with a history of cognitive impairment and low social support, who suffered acute methotrexate toxicity. A description is also presented on the characteristics of the toxicity cases due this drug admitted to this hospital in the last 7 years.