RESUMO
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Assuntos
Humanos , Transtornos Psicóticos/diagnóstico por imagem , Esquizofrenia/diagnóstico por imagem , Transtorno Bipolar/diagnóstico por imagem , Neuroimagem/instrumentação , Algoritmos , Diagnóstico Diferencial , Cérebro/anatomia & histologia , Cérebro/diagnóstico por imagemRESUMO
No disponible
Assuntos
Humanos , Transtornos Cognitivos/fisiopatologia , Transtorno Bipolar/fisiopatologia , Neuroimagem Funcional , Memória de Longo Prazo , Função Executiva , Afeto , Transtorno Bipolar/psicologia , Transtornos Cognitivos/psicologiaRESUMO
OBJECTIVE: Brain structural changes in schizoaffective disorder, and how far they resemble those seen in schizophrenia and bipolar disorder, have only been studied to a limited extent. METHOD: Forty-five patients meeting DSM-IV and RDC criteria for schizoaffective disorder, groups of patients with 45 matched schizophrenia and bipolar disorder, and 45 matched healthy controls were examined using voxel-based morphometry (VBM). RESULTS: Analyses comparing each patient group with the healthy control subjects found that the patients with schizoaffective disorder and the patients with schizophrenia showed widespread and overlapping areas of significant volume reduction, but the patients with bipolar disorder did not. A subsequent analysis compared the combined group of patients with the controls followed by extraction of clusters. In regions where the patients differed significantly from the controls, no significant differences in mean volume between patients with schizoaffective disorder and patients with schizophrenia in any of five regions of volume reduction were found, but mean volumes in the patients with bipolar disorder were significantly smaller in three of five. CONCLUSION: The findings provide evidence that, in terms of structural gray matter brain abnormality, schizoaffective disorder resembles schizophrenia more than bipolar disorder.
Assuntos
Transtorno Bipolar/patologia , Encéfalo/patologia , Substância Cinzenta/patologia , Transtornos Psicóticos/patologia , Esquizofrenia/patologia , Adulto , Mapeamento Encefálico/métodos , Estudos de Casos e Controles , Imagem de Difusão por Ressonância Magnética/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neuroimagem/métodosRESUMO
Cannabis has been commonly regarded as an innocuous drug, and has been used for centuries due to its multiple therapeutic effects (analgesic, anticonvulsant, sedative, antidepressant, etc.). However, growing evidence in recent years highlights the risk of adverse effects secondary to dependence and withdrawal syndrome. We report a case of severe cannabis dependence, that led to a variety of psychopathological, cognitive and somatic symptoms. This is compared with the bibliography and we analyze the influence of a possible underlying psychiatric disease. The adverse effects include affective and eating disorders, and the possibility of seizure induction. A novel therapeutic strategy in cannabis dependence is reported. Key words: Cannabis. Mania. Bulimic behaviors.
Assuntos
Transtornos Cognitivos/etiologia , Abuso de Maconha/complicações , Transtornos Somatoformes/etiologia , Adulto , Feminino , Humanos , Transtornos Somatoformes/tratamento farmacológicoRESUMO
El cannabis ha sido considerado históricamente una droga inocua y utilizado durante siglos por sus múltiples efectos terapéuticos (analgésico, anticonvulsivo, sedante, antidepresivo, etc.). Sin embargo, en los últimos años existe una creciente evidencia de la existencia de efectos adversos , derivados de la dependencia y abstinencia. Describimos un caso clínico de dependencia grave de cannabis que presenta una sintomatología polimorfa, a nivel psicopatológico, cognitivo y somático; la contrastamos con la bibliografía y analizamos la influencia de un posible trastorno psiquiátrico subyacente. Del síndrome clínico destacan las alteraciones afectivas y de la conducta alimentaria, así como la posible relación con una crisis comicial. Comentamos por último una nueva estrategia terapéutica en la dependencia de cannabis (AU)
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