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Arch Bronconeumol ; 52(6): 289-92, 2016 Jun.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-26584529

RESUMO

BACKGROUND: Tuberculosis (TB) remains a major public health problem. In 2013, 9 million new cases of active TB were estimated globally and the proportion of reported new cases with multi-drug resistance (MDR) was 3.5%. METHODS: Contact tracing of a case of pulmonary tuberculosis was performed in a Bolivian patient. Diagnostic tests were performed according to national and local protocols. RESULTS: An outbreak of tuberculosis in an immigrant community was detected, with 5 cases originating from one index case. Genotyping and drug susceptibility testing of the sputum samples determined Mycobacterium tuberculosis resistant to isoniazid (KatG-msp unmutated/inhA 5RBS CT). Active case finding revealed a total of 39 contacts with an incidence of latent infection of 71.43%. CONCLUSIONS: The present study confirms the importance of active case finding through contact tracing as well as rapid laboratory diagnosis to achieve improvements in early detection of TB. Early diagnosis of the patient, compliance with appropriate treatment protocols and monitoring of drug resistance are considered essential for the prevention and control of TB.


Assuntos
Antituberculosos/uso terapêutico , Surtos de Doenças , Emigrantes e Imigrantes , Tuberculose Resistente a Múltiplos Medicamentos/epidemiologia , Tuberculose Pulmonar/epidemiologia , Adulto , Antituberculosos/farmacologia , Vacina BCG , Bolívia/etnologia , Busca de Comunicante , Feminino , Humanos , Testes de Liberação de Interferon-gama , Isoniazida/farmacologia , Tuberculose Latente/tratamento farmacológico , Tuberculose Latente/epidemiologia , Masculino , Mycobacterium tuberculosis/efeitos dos fármacos , Mycobacterium tuberculosis/genética , Mycobacterium tuberculosis/isolamento & purificação , Espanha/epidemiologia , Teste Tuberculínico , Tuberculose Resistente a Múltiplos Medicamentos/tratamento farmacológico , Tuberculose Resistente a Múltiplos Medicamentos/transmissão , Tuberculose Pleural/tratamento farmacológico , Tuberculose Pleural/epidemiologia , Tuberculose Pulmonar/tratamento farmacológico , Tuberculose Pulmonar/transmissão
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