1.
Bioorg Med Chem Lett
; 10(15): 1745-8, 2000 Aug 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10937738
RESUMO
The synthesis and structure activity relationships (SAR) of a series of novel selective COX-2 inhibitors are reported. The results show that some of the 1,3,4-triaryl-3-pyrrolin-2-ones 1 are more potent as COX-2 inhibitors than celecoxib, and that lactam Id has the same selectivity.