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1.
RGO (Porto Alegre) ; 67: e20190049, 2019. tab
Artigo em Inglês | LILACS | ID: biblio-1040935

RESUMO

ABSTRACT Objective: To examine the relationship between nutritional status and dental caries of schoolchildren from Sobral, Ceará, Braszil. Methods: Dental health and nutritional status of 92 children studying in two different schools and aging 5 years old were evaluated. The nutritional status was evaluated using the Body Mass Index (BMI), and the dental health status was evaluated using the Decayed, Missing, and Filling Tooth Index (DMFT-index). An interview with the parents of the children was also performed to investigate the socioeconomic profile and nutritional habits of the children. Results: A DMFT-index of 1.97 was found, and 39.6% of the childrenpresented overweight. Higher prevalence of dental caries was associated with low income, public schools, and less schooled parents. The variable overweight presented the inverse situation found for dental caries. Moreover, it was observed lower prevalence of caries in overweight children. Conclusion: Dental caries and nutritional status exhibited different behaviors in the population studied, which were driven by the sociodemographic profile of the family.


RESUMO Objetivo: estabelecer a relação do estado nutricional e o desenvolvimento da cárie dentária em pré-escolares no município de Sobral, Ceará. Métodos: foram realizados uma avaliação nutricional e um levantamento epidemiológico em saúde bucal numa amostra constituída por 92 crianças na faixa etária de 5 anos em duas escolas do município. O estado nutricional foi avaliado através do índice IMC/idade e a cárie dentária a partir do índice do ceo-d. Foi realizado uma entrevista com os pais sobre as variáveis socioeconômicase marcadores de consumo alimentar. Resultados: o ceo-d encontrado foi de 1,97 e 39,6% das crianças apresentaram excesso de peso. Observou-se que a cárie dentária estava relacionada com a menor renda familiar, escola pública e menor escolaridade dos pais, enquanto que o excesso de peso observou-se uma relação inversa. Verificou-se que as crianças que apresentaram excesso de peso foram aquelas com menor prevalência de cárie. Conclusão: a cárie dentária e o excesso de peso demonstraram padrões decomportamentos diferentes na população infantil de acordo com as condições socioeconômicas da família.

2.
Int Immunopharmacol ; 38: 313-23, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-27344040

RESUMO

Temporomandibular joint (TMJ) disorders show inflammatory components, heavily impacting on quality of life. Abelmoschus esculentus is largely cultivated in Northeastern Brazil for medicinal purposes, having it shown anti-inflammatory activity. We evaluated A. esculentus lectin (AEL) efficacy in reducing zymosan-induced temporomandibular joint inflammatory hypernociception in rats along with the mechanism of action through which it exerts anti-inflammatory activity. Animals were pre-treated with AEL (0.01, 0.1 or 1mg/kg) before zymosan (Zy) injection in the TMJ to determine anti-inflammatory activity. To analyse the possible effect of the hemeoxygenase-1 (HO-1) and the nitric oxide (NO) pathways on AEL efficacy, animals were pre-treated with ZnPP-IX (3mg/kg), a specific HO-1 inhibitor, or aminoguanidine (30mg/kg), a selective iNOS inhibitor, before AEL administration. Von Frey test evaluated inflammatory hypernociception, synovial fluid collection was performed to determine leukocyte counting and myeloperoxidase (MPO) activity 6h after Zy injection, and Evans Blue extravasation determined vascular permeability. TMJ tissue was collected for histopathological analysis (H&E) and immunohistochemistry (TNF-α, IL-1ß, HO-1). In addition, TMJ tissue and trigeminal ganglion collection was performed for TNF-α and IL-1ß dosage (ELISA). AEL increased inflammatory nociceptive threshold, reduced leukocyte influx along with MPO activity, leukocyte influx into the synovial membrane, and Evans Blue extravasation. It promoted HO-1 overexpression whilst decreased TNF-α and IL-1ß expression in the TMJ tissue. AEL reduced TNF-α and IL-1ß levels in TMJ tissue and trigeminal ganglion. AEL effects, however, were not observed in the presence of ZnPP-IX. These findings suggest that AEL efficacy depends on TNF-α/IL-1ß inhibition and HO-1 pathway integrity.


Assuntos
Abelmoschus/imunologia , Anti-Inflamatórios/uso terapêutico , Heme Oxigenase-1/metabolismo , Inflamação/tratamento farmacológico , Hipernutrição/tratamento farmacológico , Lectinas de Plantas/uso terapêutico , Articulação Temporomandibular/efeitos dos fármacos , Animais , Permeabilidade Capilar/efeitos dos fármacos , Heme Oxigenase-1/antagonistas & inibidores , Inflamação/induzido quimicamente , Interleucina-1beta/metabolismo , Masculino , Óxido Nítrico Sintase Tipo II/metabolismo , Hipernutrição/induzido quimicamente , Protoporfirinas/farmacologia , Ratos , Ratos Wistar , Transdução de Sinais/efeitos dos fármacos , Articulação Temporomandibular/patologia , Fator de Necrose Tumoral alfa/metabolismo , Zimosan
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