Effects of plasma rich in growth factors on wound healing in patients with venous ulcers.

Introduction: Significant evidence suggests that plasma-rich in growth factors (PRGF) favor the repair of chronic wounds, enabling a rapid return to functionality. However, components of PRGF and their effects on persistent ulcers and epithelial tissues are not well characterized. The goals of this research were to analyze the biological properties of platelet-derived factors, to examine their effectiveness on healing of venous ulcers, and to establish a correlation with clinical and sociodemographic data. Methods: For the preparation of PRGF, the centrifugation technique was used, obtaining a 100 % autologous and biocompatible blood sample that was treated with sodium citrate and calcium chloride. The patients were attended weekly at the outpatient clinic for nursing consultation and wound dressing changes, with PRGF application every 15 days. The treatment protocols are described, and follow-up results are reported. Results: Initially, the patients' ulcers ranged in sizes from 4 to 84 cm2. After 12 weeks of treatment, there was a significant mean reduction of 46.2 % in ulcer area. At baseline, epithelial tissue was absent in all venous ulcers, but its presence grew significantly by the treatment period. However, the reduction of the area of the ulcers did not show significant correlation with the concentrations of the patient's growth factors. Conclusions: Using the established protocol for PRGF isolating, it was possible to obtain a product with the presence of the six growth factors related to tissue regeneration and observed a positive response on wound healing following treatment of venous ulcers, with capacity to accelerate re-epithelialization and restore the skin functional integrity.

Aerobic resistance, functional autonomy and quality of life (QoL) of elderly women impacted by a recreation and walking program.

The present study had as a goal to analyze the impact of a physical activity program (recreation and walking) over the aerobic resistance, the functional autonomy and the quality of life of elderly women. To this experimental study the elderly women (65±6.40 years old) were randomly separated in experimental group (EG, n=31) and a control group (CG, n=28). A 6-min-walking test (aerobic resistance); a protocol of autonomy evaluation of the Latin-American Group for Maturity Development (functional autonomy), and the WHO QoL-old tests were utilized. The intervention happened with classes of recreation and walking practice, three times a week, for 1h, during 4 months. The results found revealed significant improvement for the EG at the aerobic resistance (Δ%=29.06%, p=0.0001), functional autonomy (Δ%=-27.15%, p=0.0001) and QoL (Δ%=15.47%, p=0.0001). It was concluded that the systematic physical exercise interferes in a positive way at the autonomy, aerobic resistance and QoL of the elderly women.

Quality of life (QOL) axiological profile of the elderly population served by the Family Health Program (FHP) in Brazil.

With the purpose of optimizing the satisfaction of the elderly subjects, either existential or not, presenting their unique preference, this research aimed to evaluate the effects of aging on QOL of the aged persons, served by the FHP. The basic intention was to establish parameters of QOL-impact on aging. Our sample was a non-selected population of aged volunteers from Perequê-Mirim-I Family Health Unity, in Caraguatatuba, São Paulo, Brazil. In this correlational descriptive research, the elderly subjects answered a questionnaire on QOL, specific to the aged persons (WHOQOL-OLD). These answers revealed the degree to which of the six facets of WHOQOL-OLD was given priority. The dimensional techniques of descriptive statistics (mean+/-S.D., median, coefficient of variation) normality evaluation (Kolmogorov-Smirnov), and inferential statistical techniques (Z-score test, chi2) were adopted, considering the level-II error=10% and accepting level-I error=5%. The main results revealed a correlation between the income and QOL. Death and dying appeared to be a substantial preoccupation, opposed to intimacy that raised the QOL level. It is suggested that any works directed to the elderly population should take in consideration the self-evaluation of aging effects on QOL.