Solar Gas-Phase CO2 Hydrogenation by Multifunctional UiO-66 Photocatalysts.

Solar-assisted CO2 conversion into fuels and chemical products involves a range of technologies aimed at driving industrial decarbonization methods. In this work, we report on the development of a series of multifunctional metal-organic frameworks (MOFs) based on nitro- or amino-functionalized UiO-66(M) (M: Zr or Zr/Ti) supported RuOx NPs as photocatalysts, having different energy band level diagrams, for CO2 hydrogenation under simulated concentrated sunlight irradiation. RuOx(1 wt %; 2.2 ± 0.9 nm)@UiO-66(Zr/Ti)-NO2 was found to be a reusable photocatalyst, to be selective for CO2 methanation (5.03 mmol g-1 after 22 h;, apparent quantum yield at 350, 400, and 600 nm of 1.67, 0.25, and 0.01%, respectively), and to show about 3-6 times activity compared with previous investigations. The photocatalysts were characterized by advanced spectroscopic techniques like femto- and nanosecond transient absorption, spin electron resonance, and photoluminescence spectroscopies together with (photo)electrochemical measurements. The photocatalytic CO2 methanation mechanism was assessed by operando FTIR spectroscopy. The results indicate that the most active photocatalyst operates under a dual photochemical and photothermal mechanism. This investigation shows the potential of multifunctional MOFs as photocatalysts for solar-driven CO2 recycling.

Valorization of Field-Spent Granular Activated Carbon as Heterogeneous Ozonation Catalyst for Water Treatment.

Developing sustainable cost-effective strategies for valorization of field-spent granular activated carbon (s-GAC) from industrial water treatment has gained much interest. Here, we report a cost-effective strategy for the regeneration of s-GAC as an adsorbent in a large-scale drinking water treatment plant and used as an efficient and durable ozonation catalyst in water. To achieve this, a series of samples is prepared by subjecting s-GAC to thermally controlled combustion treatments with and without pyrolysis. The catalytic performance of the optimized sample is evaluated for oxalic acid degradation as the model pollutant under batch (>15 h) and continuous flow operations (>200 h). The partially deactivated catalyst upon reuse is restored by thermal treatment. Electron paramagnetic resonance and selective quenching experiments show the formation of singlet oxygen (1O2) during catalytic ozonation. The GAC-ozonation catalyst is efficient to minimize the formation of chlorinated disinfection by-products like trihalomethanes and haloacetic acids in an urban wastewater effluent.

Metal-Organic Frameworks as Photocatalysts for Solar-Driven Overall Water Splitting.

Metal-organic frameworks (MOFs) have been frequently used as photocatalysts for the hydrogen evolution reaction (HER) using sacrificial agents with UV-vis or visible light irradiation. The aim of the present review is to summarize the use of MOFs as solar-driven photocatalysts targeting to overcome the current efficiency limitations in overall water splitting (OWS). Initially, the fundamentals of the photocatalytic OWS under solar irradiation are presented. Then, the different strategies that can be implemented on MOFs to adapt them for solar photocatalysis for OWS are discussed in detail. Later, the most active MOFs reported until now for the solar-driven HER and/or oxygen evolution reaction (OER) are critically commented. These studies are taken as precedents for the discussion of the existing studies on the use of MOFs as photocatalysts for the OWS under visible or sunlight irradiation. The requirements to be met to use MOFs at large scale for the solar-driven OWS are also discussed. The last section of this review provides a summary of the current state of the field and comments on future prospects that could bring MOFs closer to commercial application.

Metal Nodes of Metal-Organic Frameworks can Activate Molecular Hydrogen.

Hydrogenation of multiple bonds are among the most general and important organic reactions. Typical heterogeneous catalysts are based on transition metal nanoparticles, including noble metals. Data are presented here showing that metal nodes of MIL-101(Cr) and UiO-66 in the absence of occluded metal nanoparticles can promote hydrogenation of polarized X=Y double bonds of nitro and carbonyl groups. The catalytic activity is a function of the composition of the metal node and the organic linker. It is proposed that the reaction mechanism is based on the operation of frustrated Lewis acid/base pairs.

Complications Post-COVID-19 and Risk Factors among Patients after Six Months of a SARS-CoV-2 Infection: A Population-Based Prospective Cohort Study.

In October 2020, we conducted a population-based prospective cohort study to determine post-COVID-19 complications, recovery, return to usual health, and associated risk factors in 536 cases of COVID-19 outbreak in Borriana (Spain) by administering an epidemiological questionnaire via phone interviews. A total of 484 patients participated (90.3%), age mean 37.2 ± 17.1 years, and 301 females (62.2%). Mild illness was the most common COVID-19 manifestation. After six months, 160 patients (33.1%) suffered at least one complication post-COVID-19, and 47 (29.4%) of them sought medical assistance. The most frequent persistent symptoms were hair loss, fatigue, loss of smell or taste, and headache. Risk factors associated with a complication were female sex (adjusted relative risk, [aRR] = 1.93 95% confidence interval [CI] 1.41-2.65), age 35 years and above (aRR = 1.50 95% CI 1.14-1.99), B blood group (aRR = 1.51 95% CI 1.04-2.16), current smoker (RR = 1.61 95% CI 1.02-2.54), and at least a COVID-19 exposure (aRR = 2.13 95% CI 1.11-4.09). Male sex, age younger than 35 years, and low COVID-19 exposures were associated with better recovery and return to usual health. A third of patients presented persistent symptoms compatible with the long-COVID-19 syndrome. In conclusion, an active medical follow-up of post-COVID-19 patients must be implemented.

Photocatalytic Hydrogen Production from Glycerol Aqueous Solutions as Sustainable Feedstocks Using Zr-Based UiO-66 Materials under Simulated Sunlight Irradiation.

There is an increasing interest in developing cost-effective technologies to produce hydrogen from sustainable resources. Herein we show a comprehensive study on the use of metal-organic frameworks (MOFs) as heterogeneous photocatalysts for H2 generation from photoreforming of glycerol aqueous solutions under simulated sunlight irradiation. The list of materials employed in this study include some of the benchmark Zr-MOFs such as UiO-66(Zr)-X (X: H, NO2, NH2) as well as MIL-125(Ti)-NH2 as the reference Ti-MOF. Among these solids, UiO-66(Zr)-NH2 exhibits the highest photocatalytic H2 production, and this observation is attributed to its adequate energy level. The photocatalytic activity of UiO-66(Zr)-NH2 can be increased by deposition of small Pt NPs as the reference noble metal co-catalyst within the MOF network. This photocatalyst is effectively used for H2 generation at least for 70 h without loss of activity. The crystallinity of MOF and Pt particle size were maintained as revealed by powder X-ray diffraction and transmission electron microscopy measurements, respectively. Evidence in support of the occurrence of photoinduced charge separation with Pt@UiO-66(Zr)-NH2 is provided from transient absorption and photoluminescence spectroscopies together with photocurrent measurements. This study exemplifies the possibility of using MOFs as photocatalysts for the solar-driven H2 generation using sustainable feedstocks.

Photocatalytic Water Splitting Promoted by 2D and 3D Porphyrin Covalent Organic Polymers Synthesized by Suzuki-Miyaura Carbon-Carbon Coupling.

This work deals with the synthesis of metal-free and porphyrin-based covalent organic polymers (COPs) by the Suzuki-Miyaura coupling carbon-carbon bond forming reaction to study the photocatalytic overall water splitting performance. Apart from using 5,10,15,20-Tetrakis-(4-bromophenyl)porphyrin, we have chosen different cross-linker monomers to induce 2-dimensional (2D) or 3-dimensional (3D) and different rigidity in their resulting polymeric molecular structure. The synthesised COPs were extensively characterised to reveal that the dimensionality and flexibility of the molecular structure play an intense role in the physical, photochemical, and electronic properties of the polymers. Photoinduced excited state of the COPs was evaluated by nanosecond time-resolved laser transient absorption spectroscopy (TAS) by analysing excited state kinetics and quenching experiments, photocurrent density measurements and photocatalytic deposition of Ru3+ to RuO2, and photocatalysis. In summary, TAS experiments demonstrated that the transient excited state of these polymers has two decay kinetics and exhibit strong interaction with water molecules. Moreover, photocurrent and photocatalytic deposition experiments proved that charges are photoinduced and are found across the COP molecular network, but more important charges can migrate from the surface of the COP to the medium. Among the various COPs tested, COP-3 that has a flexible and 3D molecular structure reached the best photocatalytic performances, achieving a photocatalytic yield of 0.4 mmol H2 × gCOP-3-1 after 3 h irradiation.

Quasi-HKUST Prepared via Postsynthetic Defect Engineering for Highly Improved Catalytic Conversion of 4-Nitrophenol.

HKUST-1 [Cu3(BTC)2(H2O)3]n·nH2OMeOH was submitted to thermolysis under controlled conditions at temperatures between 100 and 300 °C. This treatment resulted in partial ligand decarboxylation, generating coordinatively unsaturated Cu2+ sites with extra porosity on the way to the transformation of the initial HKUST-1 framework to CuO. The obtained materials retaining in part the HKUST-1 original crystal structure (quasi-MOFs) were used to promote 4-nitrophenol conversion to 4-aminophenol. Because of the partial linker decomposition, the quasi-MOF treated at 240 °C contains coordinatively unsaturated Cu2+ ions distributed throughout the Q-HKUST lattice together with micro- and mesopores. These defects explain the excellent catalytic performance of QH-240 with an apparent rate constant of 1.02 × 10-2 s-1 in excess of NaBH4 and an activity factor and half-life time of 51 s-1g-1 and 68 s, respectively, which is much better than that of the HKUST parent. Also, the induction period decreases from the order of minutes to seconds in the presence of the HKUST and QH-240 catalysts, respectively. Kinetic studies fit with the Langmuir-Hinshelwood theory in which both 4-nitrophenol and BH4- should be adsorbed onto the catalyst surface. The values of the true rate constant (k), the adsorption constants of 4-nitrophenol and BH4- (K4-NP and KBH4-), as well as the activation energy are in agreement with a rate-determining step involving the reduction of 4-nitrophenol by the surface-bound hydrogen species.

ABO Blood Groups and the Incidence of Complications in COVID-19 Patients: A Population-Based Prospective Cohort Study.

After a COVID-19 outbreak in the Falles festival of Borriana (Spain) during March 2020, a cohort of patients were followed until October 2020 to estimate complications post-COVID-19, considering ABO blood groups (ABO). From 536 laboratory-confirmed cases, 483 completed the study (90.1%) carried by the Public Health Center of Castelló and the Emergency and Microbiology and Clinical Analysis of Hospital de la Plana Vila-real. The study included ABO determination and telephone interviews of patients. The participants had a mean age of 37.2 ± 17.1 years, 300 females (62.1%). ABO were O (41.4%), A (45.5%), B (9.1%), and AB (3.9%). We found no difference in the incidence of COVID-19 infections. A total of 159 (32.9%) patients reported one or more post-COVID-19 complications with divergent incidences after adjustment: O (32.3%), A (32.6%), B (54.1%), and AB (27.6%); B groups had more complications post-COVID-19 when compared with O group (adjusted relative risk [aRR] 95% confidence interval [CI] 1.68, 95% CI 1.24-2.27), and symptoms of fatigue (1.79, 95% CI 1.08-2.95), myalgia (2.06, 95% CI 1.10-3.84), headache (2.61, 95% CI 1.58-4.31), and disorder of vision (4.26 95% CI 1.33-13.60). In conclusion, we observed significant differences in post-COVID-19 complications by ABO, with a higher incidence in B group. Additional research is justified to confirm our results.

Improved catalytic hydrogen release of quasi HKUST-1 compared to HKUST-1.

On-demand hydrogen release could be an important process for the transportation of fuel in the near future. Herein it is reported that the controlled thermolysis of HKUST-1 under optimal conditions generates structural defects resulting in a quasi-HKUST-1 material showing a 20-fold enhancement of the H2 release turnover frequency at room temperature in the absence of a base.

Child-to-Parent Violence, Peer Victimization and Cybervictimization in Spanish Adolescents.

The aim of this study was to analyse the relationship between child-to-parent violence (CPV) (high, moderate and low), peer victimization (PV) (relational and overt, both physical and verbal) and cybervictimization (CV) (relational and overt), taking into account the role of sex. 1304 adolescents (53.14% girls) between the ages of 11 and 18 enrolled at secondary schools in the Autonomous Communities of Valencia, Aragón and Andalusia participated in the study. Adolescents with high CPV scores obtained higher scores for all types of PV and CV compared to the other CPV groups. Boys scored higher than girls in overt physical PV and in overt CV and girls obtained higher scores in relational PV. A statistically significant interaction effect was observed; boys with high CPV scores reported greater overt CV. The results suggest the importance of CPV in relation to specific forms of PV and CV and highlight the need to take into account the different processes of family socialization between boys and girls to reduce the likelihood of adolescents being victimized.

Cybervictimization, Offline Victimization, and Cyberbullying: The Mediating Role of the Problematic Use of Social Networking Sites in Boys and Girls / Cibervictimización, victimización offline y ciberbullying: el rol mediador del uso problemático de las redes sociales virtuales en chicos y chicas

The aim of the present study was to examine the mediating role of the problematic social networking sites use (PSNSU) in the relationship between both cybervictimization and offline victimization and cyberbullying in boys and girls. The sample consisted of 2,011 adolescents (50.67% boys and 49.32% girls), aged between 12 and 18 years old (M = 14.17, SD = 1.47), enrolled in schools in Andalusia, Spain. To examine this objective, moderated mediation model of the PROCESS macro was used. The results showed that both cybervictimization and offline victimization are positively related to cyberbullying directly and indirectly through PSNSU. Moreover, it was observed that boys victimized both online and offline demonstrated a higher involvement in cyberbullying, whereas girls reported a higher PSNSU. However, the PSNSU mediating effect was not moderated by gender. Finally, the results and their practical implications are discussed. (AU)

El objetivo del presente estudio fue examinar el papel mediador del uso problemático de las redes sociales virtuales (UPRSV) en la relación entre la cibervictimización, la victimización offline y el ciberbullying en chicos y chicas. Los participantes fueron 2,011 adolescentes (50.67% chicos y 49.32% chicas), con edades comprendidas entre los 12 y los 18 años (M = 14.17, DT = 1.47), escolarizados en centros educativos de Andalucía (España). Para examinar este objetivo se utilizó el modelo de mediación moderada de la macro de PROCESS. Los resultados obtenidos mostraron que la cibervictimización y la victimización offline se relacionan positivamente con el ciberbullying de manera directa e indirecta, a través del UPRSV. Además, se observó que los chicos victimizados tanto online como offline mostraron una mayor implicación en el ciberbullying mientras que las chicas mostraron un mayor UPRSV. Sin embargo, el efecto mediador del UPRSV no era moderado por el género. Finalmente se discuten los resultados y sus implicaciones prácticas. (AU)

"Mass gathering events and COVID-19 transmission in Borriana (Spain): A retrospective cohort study".

OBJECTIVE: Mass gathering events (MGEs) are associated with the transmission of COVID-19. Between 6 and 10 March 2020, several MGEs related to the Falles festival took place in Borriana, a municipality in the province of Castellon (Spain). The aim of this study was to estimate the incidence of COVID-19 and its association with these MGEs, and to quantify the potential risk factors of its occurrence. METHODS: During May and June 2020, a population-based retrospective cohort study was carried out by the Public Health Center of Castelló and the Hospital de la Plana in Vila-real. Participants were obtained from a representative sample of 1663 people with potential exposure at six MGEs. A questionnaire survey was carried out to obtain information about attendance at MGEs and COVID-19 disease. In addition, a serologic survey of antibodies against SARS-Cov-2 was implemented. Inverse probability weighted regression was used in the statistical analysis. RESULTS: A total of 1338 subjects participated in the questionnaire survey (80.5%), 997 of whom undertook the serologic survey. Five hundred and seventy cases were observed with an attack rate (AR) of 42.6%; average age was 36 years, 62.3% were female, 536 cases were confirmed by laboratory tests, and 514 cases were found with SARS-CoV-2 total antibodies. Considering MGE exposure, AR was 39.2% (496/1264). A dose-response relationship was found between MGE attendance and the disease, (adjusted relative risk [aRR] = 4.11 95% confidence interval [CI]3.25-5.19). Two MGEs with a dinner and dance in the same building had higher risks. Associated risk factors with the incidence were older age, obesity, and upper and middle class versus lower class; current smoking was protective. CONCLUSIONS: The study suggests the significance of MGEs in the COVID-19 transmission that could explain the subsequent outbreak in Borriana.

Enhanced Catalytic Performance of Quasi-HKUST-1 for the Tandem Imine Formation.

Copper-based metal-organic framework (Cu3 (BTC)2 (H2 O)3 ]n ⋅nH2 OMeOH (HKUST-1) has been subjected to thermolysis under air atmosphere at different temperatures ranging from 100 to 300 °C. This treatment produces the partial removal of ligands, the generation of structural defects and additional porosity in a controlled way. The resulting defective materials denoted according to the literature as quasi-MOFs, were subsequently employed as heterogeneous catalysts in the one pot synthesis of N-benzylideneaniline from aniline and benzyl alcohol in open air as terminal oxidant at 70 °C under base- and dehydrating agent-free conditions. The Q-HKUST catalysts calcined at 240 °C (QH-240) was the most efficient in the series, promoting imine synthesis. Data from Knoevenagel condensation of malononitrile shows that in QH-240 the distances of Cu ions in HKUST-1 cavities are preserved, increasing the Knoevenagel activity, but a strong rearrangement takes place at 300 °C or above. The unsaturated copper active sites with simultaneous presence of micro- and mesopores in QH-240 are responsible for this excellent catalytic performance. The effective parameters on catalytic activity of QH-240 including deligandation temperature, the amount of catalyst, the ratio of reactants, and reaction temperature as well as the stability and recyclability of the catalyst were also investigated. The possible mechanism used by QH-240 follows alcohol aerobic oxidation and subsequent anaerobic condensation of aldehyde intermediate with aniline.

Minimum Clearance Distance in Fall Arrest Systems with Energy Absorber Lanyards.

Accidents due to falls from height are one of the main causes of death in workplaces. Fall arrest systems (FAS) are designed to arrest the fall safely without injuring the accident victim. Their main mission is to restrain the body so as to prevent it from hitting the ground, generating forces and accelerations in the arrest process that are not harmful. A lack of empirical evidence and scant technical information provided by manufacturers regarding minimum clearance distance (MCD) below anchorage makes it necessary to study the safety distances required in the use of Energy Absorber Lanyards (EAL). This paper aims to determine the MCD below anchorage to arrest a fall using an EAL without hitting the ground. The real deformation of EAL when stopping a fall is studied. Ten EAL models distributed internationally by six manufacturers were chosen. Dynamic behavior tests were performed on the samples. Using image processing the total elongation of the equipment (elastic plus plastic) is obtained. The main conclusions are that maximum plastic elongation could be reduced by 29%. The method described in EN 355: 2002 underestimates elongation by up to 70% for some equipment 20% of EAL's exceed the maximum arrest force (Fm) allowed in EN 355. The MCD data provided by manufacturers is not reliable. The data provided by manufacturers are incomplete. It is recommended that quality control for EAL's be strengthened to ensure that products launched onto the market meet the requirement of EN355. The findings of this study recommended increasing MCD distance longer than that calculated according to EN355, at less than 1 m.

Assessment of a Multidimensional School Collective Efficacy Scale to Prevent Student Bullying: Examining Dimensionality and Measurement Invariance / Una evaluación de la Multidimensional School Collective Efficacy Scale para prevenir el acoso en escolares: el examen de la dimensionalidad y la invarianza de medida

The construct of a school collective efficacy to prevent bullying has attracted attention as a way to increase a positive, school-wide climate. The current study tested the fit of several first-order models of school collective efficacy to prevent (uni-dimensional, two-dimensional, and three-dimensional) bullying using a sample of 579 male (Mage = 14.31, SD = 1.78 years old) and 589 female (Mage = 14.56, SD = 1.83 years old) Mexican adolescents. The models were validated by the extent to which the model was invariant by gender and by educational level (secondary vs. high school). Moreover, the discriminant and concurrent validity of model dimensions were examined through their relationships with other constructs. The results suggest that school collective efficacy is a three-dimensional construct, with supporting evidence for cohesion, students’ social control, and teachers’ social control dimensions. Measurement invariance was found in this three-dimensional measurement model by gender and educational level. The latent means difference analysis showed some differences by gender and educational level on factors of school collective efficacy. Finally, results support our hypotheses related to discriminant and concurrent validity in relation to external variables. Overall, findings indicate this three-dimensional model is useful to measure adolescents’ perceptions of school collective efficacy. (AU)

El constructo eficacia escolar colectiva para la prevención del acoso escolar ha recibido una creciente atención como una forma de mejorar el clima escolar. En el presente estudio se evaluó el ajuste de varios modelos de primer orden para medir la autoeficacia escolar colectiva para la prevención del acoso escolar (unidimensional, bidimensional y tridimensional), utilizando una muestra de 579 chicos (Medad = 14.31, DS = 1.78 años) y 589 chicas (Medad = 14.56, DS = 1.83 años) mexicanos. Para validar el modelo en distintos grupos se analizó la invarianza de medida por sexo y nivel educativo (secundaria vs. bachillerato). Además, se examinó la validez discriminante y concurrente analizando la relación de la eficacia escolar colectiva con otros constructos. Los resultados indican que la eficacia escolar colectiva es un constructo tridimensional conformado por las dimensiones de cohesión y confianza, control social de los estudiantes y control social de los docentes. La evidencia constata la invarianza de medida del modelo por sexo y nivel educativo. El análisis de las diferencias de medias latentes muestra diferencias por sexo y nivel educativo en las dimensiones de la eficacia escolar colectiva. Finalmente, los resultados confirman las hipótesis relativas a las relaciones de la eficacia escolar colectiva con otros constructos. Los hallazgos sugieren que el modelo tridimensional es útil para medir la percepción adolescente de la eficacia escolar colectiva. (AU)

The Mediating Role of Classroom Climate on School Violence.

Mediation analysis has been confirmed as a very useful statistical tool in the social sciences, especially in school-related studies. This type of analysis was used in the present study to examine the mediating role of classroom climate (measured with the classroom environmental scale), categorized into three dimensions, namely involvement, affiliation, and teacher support, on the relationship between peer victimization and peer aggression. The participants consisted of 2011 adolescents (50.67% boys and 49.32% girls), aged between 12 and 18 years old (M = 14.17; SD = 1.47), enrolled in schools in Andalusia (Spain). Findings revealed a significant direct relationship of all the dimensions. They also revealed that teacher support was the only dimension that mediates in the relationship between peer violence and peer aggression. The results and their implications for improving classroom climate and school violence are discussed.

Photoactive Zr and Ti Metal-Organic-Frameworks for Solid-State Solar Cells.

Solid-state photovoltaic cells based on robust metal-organic frameworks (MOFs), MIL-125(Ti), MIL-125(Ti)-NH2 , UiO-67, Ru(bpy)2 -UiO-67, (bpy 2,2'-bipyridine) as active components and spiro-MeOTAD (MeOTAD 2,2',7,7'-tetrakis[N,N-di(p-methoxyphenyl)amino]-9,9'-spirobifluorene) as hole transporting layer have been prepared., The photovoltaic response of this material increases in the presence of bathochromic -NH2 groups on the linker or Ru (II) polypyridyl complexes light harvester. These results show that the strategies typically employed in photocatalysis to enhance the photocatalytic activity of MOFs can also be applied in the field of photovoltaic devices.

Genetic deletion of dopamine D1 receptors increases the sensitivity to cannabinoid CB1 receptor antagonist-precipitated withdrawal when compared with wild-type littermates: studies in female mice repeatedly exposed to the Spice cannabinoid HU-210.

RATIONALE: The emergence of the consumption of highly potent synthetic cannabinoid receptor agonists (spice drugs) that produce important neurological symptoms has prompted the research on the consequences of acute and chronic use of these new psychoactive substances. Most studies on cannabinoid dependence have been performed in male animals, and there is a need of studies using female subjects. OBJECTIVES: In the present study, we evaluated only in female animals the role of dopamine D1 receptors in the behavioral responses induced by acute and repeated stimulation of cannabinoid CB1 receptors, including the development of physical dependence, since cannabinoid CB1 receptors are co-localized with dopamine D1 receptors on GABAergic neurons projecting to the substantia nigra. METHODS: To this end, female dopamine D1 receptor-deficient mice and wild-type littermates were treated with HU-210, a potent synthetic cannabinoid agonist. RESULTS: Mutant mice displayed an enhanced response to acute motor and hypothermic effects to HU-210 when compared with wild-type females. The administration of SR141716A precipitated behavioral signs of withdrawal in mice treated subchronically with HU-210. Severity of cannabinoid withdrawal syndrome was potentiated in dopamine D1-deficient female mice. Indeed, 4 of 6 abstinence signs were increased in mutant mice. CONCLUSIONS: These results support for a role of dopamine D1 receptors in the acute, chronic, and withdrawal actions of spice drugs.

Forgiveness and Loneliness in Peer-Victimized Adolescents.

The purpose of the present study was to analyze the relationships between forgiveness, motivations for revenge, avoidance, and benevolence; loneliness, emotional loneliness and positive subjective evaluation of the social network; and peer victimization in schools, relational, overt physical, and overt verbal, based on gender. A battery of instruments was administered to 617 Spanish students (50.7% boys and 49.3% girls), aged between 10 and 16 years (M = 13.04 years, SD = 1.80 years) from primary and secondary education. A multivariate analysis of variance and a multiple block regression for data analysis was used. Study results revealed that the most victimized students showed greater motivation for revenge and avoidance, as well as a greater perception of emotional loneliness and less positive subjective evaluation of their social network. In addition, the findings obtained in the regression analysis (stepwise) indicated that being a boy between 11 and 13 years old and having a high level of emotional loneliness and high avoidance motivation were the most important predictors of peer victimization. Finally, the findings and their possible implications in the design of intervention projects that encourage forgiveness in interpersonal conflicts and integration in social networks as preventive strategies of peer victimization were discussed.