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1.
S Afr Med J ; 111(9): 838-840, 2021 09 02.
Artigo em Inglês | MEDLINE | ID: mdl-34949246

RESUMO

Since completion of the Human Genome Project at the turn of the century, there have been significant advances in genomic technologies together with genomics research. At the same time, the gap between biomedical discovery and clinical application has narrowed through translational medicine, so establishing the era of personalised medicine. In bridging these two disciplines, the clinician-scientist has become an integral part of modern practice. Surgeons and surgical diseases have been less represented than physicians and medical conditions among clinician-scientists and research. Here, we explore the possible reasons for this and propose strategies for moving forward. Discovery-driven personalised medicine is both the present and the future of clinical patient care worldwide, and South Africa is uniquely placed to build capacity for biomedical discovery in Africa. Diverse engagement across clinical disciplines, including surgery, is necessary in order to integrate modern medicine into a developing-world contextualised perspective.


Assuntos
Papel do Médico , Cirurgiões , Pesquisa Translacional Biomédica , Difusão de Inovações , Educação Médica , Humanos , Apoio à Pesquisa como Assunto , África do Sul
2.
Childs Nerv Syst ; 35(10): 1881-1884, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31270574

RESUMO

PURPOSE: In this paper, we aimed to review our institutional opinions and experience with Chiari 1 malformation management to determine physician practice and outcomes. METHODS: Discussion between 3 clinicians about practice preferences and the management of Chiari 1 worldwide. Retrospective review of clinical cases over a 10-year period (2009-2018). RESULTS: Although there are some minor differences between clinicians in our practice, our approach is broadly similar. We treat incidental Chiari 1 malformations conservatively, with clinical and radiological surveillance, reserving intervention for patients who develop clinical signs or radiological deterioration. We prefer surgical intervention for patients with typical symptoms or a Chiari 1 malformation with radiological progression. If symptoms are atypical, we prefer surveillance. Our preferred operation is a conservative suboccipital craniectomy with expansion duraplasty and adhesiolysis. Our operative complication rate was low and there was no mortality or major morbidity in our series. Surveillance for incidentally discovered Chiari 1 malformations has been a safe practice in our experience. CONCLUSION: Clinical practice among three clinicians in our institution is broadly consistent. We have a conservative approach to Chiari 1 malformation management and our approach appears to have a low morbidity.


Assuntos
Malformação de Arnold-Chiari/terapia , Gerenciamento Clínico , Hospitais Pediátricos/tendências , Cruz Vermelha , Malformação de Arnold-Chiari/diagnóstico , Humanos , África do Sul/epidemiologia , Resultado do Tratamento
3.
S Afr Med J ; 104(11): 736-8, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-25909109

RESUMO

From a litigation perspective, neurosurgery is considered a 'super high-risk' field, and this has been associated with rapidly increasing malpractice cover costs. In 2013 the annual Medical Protection Society fee for cover was R250,900. We wished to determine whether high malpractice cover was influencing how neurosurgeons managed patients. A 40-question online survey asking questions on defensive medicine was distributed to determine perceptions around liability risk and whether these influenced how patients were managed. Eighty-four per cent of respondents agreed that a medicolegal crisis existed, and over half (53.8%) had been sued for malpractice during their career. Altering practice behaviour to minimise the risk of a lawsuit is common. The increasing number of legal claims against respondents in this survey has resulted in most neurosurgeons practising defensive medicine. Arguably this will result in increased healthcare costs, inferior patient care and decreased access to skilled surgeons.


Assuntos
Atitude do Pessoal de Saúde , Medicina Defensiva , Jurisprudência , Responsabilidade Legal , Neurocirurgia , Humanos , Seguro de Responsabilidade Civil , Imperícia , África do Sul , Inquéritos e Questionários
5.
Acta Neurochir Suppl ; 102: 77-80, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-19388292

RESUMO

INTRODUCTION: There has been a resurgence of interest in decompressive craniectomy for traumatic brain injury (TBI), but the impact of craniectomy on intracranial pressure (ICP) and cerebral oxygenation has not been well described for diffuse injury in children. METHODS: ICP and brain tissue oxygenation (PbtO2) changes after decompressive craniectomy for diffuse brain swelling after TBI in children were analysed. FINDINGS: Decompressive craniectomy was performed for diffuse brain swelling in 18 children under 15 years old. For 8 patients, craniectomy was performed as an emergency for malignant brain swelling, and in 10, for sustained ICP > 25 mmHg refractory to conventional medical treatment. In 6 of these patients, PbtO2 was also monitored. Median ICP was reduced from 40 mmHg before craniectomy to 16 mmHg for 24 hours thereafter, and PbtO2 improved from a median of 17.4 to 43.4 mmHg. Clinical outcome was favourable in 78%. CONCLUSIONS: In selected pediatric patients with TBI, craniectomy for diffuse brain swelling can significantly improve ICP and cerebral oxygenation control. The use of the procedure in appropriate settings does not appear to increase the proportion of disabled survivors.


Assuntos
Lesões Encefálicas/cirurgia , Encéfalo/metabolismo , Craniotomia/métodos , Descompressão Cirúrgica/métodos , Pressão Intracraniana/fisiologia , Oxigênio/metabolismo , Encéfalo/cirurgia , Edema Encefálico/cirurgia , Lesões Encefálicas/patologia , Lesões Encefálicas/fisiopatologia , Criança , Pré-Escolar , Feminino , Seguimentos , Escala de Coma de Glasgow , Humanos , Masculino
6.
Childs Nerv Syst ; 23(11): 1331-5, 2007 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-17632729

RESUMO

CASE REPORT: The authors present the case of a 5-year-old child with severe traumatic brain injury in whom decompressive hemicraniectomy was performed for progressive increased intracranial pressure (ICP) unresponsive to medical treatment. Data from ICP and cerebral tissue oxygenation monitoring in the contralateral hemisphere were recorded, which demonstrated the immediate and delayed mechanical and physiological changes occurring after bony and dural decompression. DISCUSSION: The role of the procedure and that of the monitoring approach are discussed.


Assuntos
Edema Encefálico/cirurgia , Lesões Encefálicas/cirurgia , Craniotomia/métodos , Descompressão Cirúrgica/métodos , Hipóxia Encefálica/prevenção & controle , Hipertensão Intracraniana/cirurgia , Edema Encefálico/etiologia , Lesões Encefálicas/complicações , Cérebro/lesões , Cérebro/metabolismo , Pré-Escolar , Lateralidade Funcional , Humanos , Hipertensão Intracraniana/etiologia , Masculino , Oxigênio/metabolismo , Resultado do Tratamento
7.
Childs Nerv Syst ; 23(1): 79-84, 2007 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17058085

RESUMO

INTRODUCTION: The role of endoscopy in hydrocephalus due to infectious aetiology is unclear. Tuberculous hydrocephalus is a useful model to study because it presents particular challenges and the pathophysiology of the cerebrospinal fluid disturbance is well known. MATERIALS AND METHODS: We present the results of 24 endoscopic operations in tuberculous meningitis. RESULT: Endoscopic third ventriculostomy (ETV) was attempted in 17 patients: seven were successful, five failed, and five were not completed due to abnormal anatomy. There were five fenestration procedures, three of which were successful. Endoscopic biopsy of two tuberculomas failed to yield a bacteriological result. These operations were more difficult to perform than for hydrocephalus due to other aetiologies. CONCLUSION: Although ETV is technically possible in this situation, it is imperative that the patients are adequately selected for the procedure to ensure optimal treatment and that the surgeon has experience with difficult cases.


Assuntos
Endoscopia/métodos , Hidrocefalia/cirurgia , Terceiro Ventrículo/cirurgia , Tuberculose Meníngea/cirurgia , Ventriculostomia/métodos , Biópsia , Criança , Pré-Escolar , Humanos , Hidrocefalia/microbiologia , Lactente , Recém-Nascido , Terceiro Ventrículo/microbiologia , Tuberculose Meníngea/complicações
8.
S Afr Med J ; 96(9 Pt 2): 931-40, 2006 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-17077920

RESUMO

Conjoined twins represent a rare but fascinating congenital condition, the aetiology of which remains obscure. Over the past four decades, the paediatric surgeons at Red Cross Children's Hospital have been involved in the management of 46 pairs of conjoined twins, of which 33 have been symmetrical and 12 asymmetrical. Seventeen symmetrical twins have undergone separation with 22 children (65%) surviving; all of the live asymmetrical twins survived separation. We describe the important features of this unique cohort, outline our approach to management and present the results of this approach. We consider some of the ethical and moral dilemmas we have confronted, and discuss the prenatal diagnosis, obstetric implications and postnatal care of these children, including the relevant investigations and anaesthetic and surgical management. Specific aspects related to the cardiovascular system, hepatobiliary and gastrointestinal tracts, urogenital tract, central nervous system and musculoskeletal system are highlighted.


Assuntos
Doenças em Gêmeos/epidemiologia , Hospitais de Condado/estatística & dados numéricos , Hospitais Pediátricos/estatística & dados numéricos , Gêmeos Unidos , Adolescente , Adulto , Diagnóstico Diferencial , Doenças em Gêmeos/diagnóstico , Doenças em Gêmeos/cirurgia , Procedimentos Cirúrgicos Eletivos/métodos , Feminino , Humanos , Incidência , Lactente , Recém-Nascido , Pessoa de Meia-Idade , Gravidez , Diagnóstico Pré-Natal , Prognóstico , Estudos Retrospectivos , África do Sul/epidemiologia
9.
S Afr Med J ; 96(9 Pt 2): 969-75, 2006 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-17077927

RESUMO

OBJECTIVES: Traumatic brain injury accounts for a high percentage of deaths in children. Raised intracranial pressure (ICP) due to brain swelling within the closed compartment of the skull leads to death or severe neurological disability if not effectively treated. We report our experience with 12 children who presented with cerebral herniation due to traumatic brain swelling in whom decompressive craniectomy was used as an emergency. DESIGN: Prospective, observational. SETTING: Red Cross Children's Hospital. SUBJECTS: Children with severe traumatic brain injury and cerebral swelling. OUTCOME MEASURES: Computed tomography (CT) scanning, ICP control, clinical outcome. RESULTS: Despite the very poor clinical condition of these children preoperatively, aggressive management of the raised pressure resulted in unexpectedly good outcomes. CONCLUSION: Aggressive surgical measures to decrease ICP in the emergency situation can be of considerable benefit; the key concepts are selection of appropriate patients and early intervention.


Assuntos
Edema Encefálico/cirurgia , Traumatismos Craniocerebrais/complicações , Craniotomia , Descompressão Cirúrgica/métodos , Encefalocele/cirurgia , Edema Encefálico/complicações , Edema Encefálico/diagnóstico por imagem , Criança , Pré-Escolar , Traumatismos Craniocerebrais/diagnóstico por imagem , Traumatismos Craniocerebrais/cirurgia , Encefalocele/diagnóstico por imagem , Encefalocele/etiologia , Seguimentos , Humanos , Estudos Prospectivos , Síndrome , Tomografia Computadorizada por Raios X , Índices de Gravidade do Trauma , Resultado do Tratamento
13.
Childs Nerv Syst ; 21(7): 559-65, 2005 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-15714352

RESUMO

INTRODUCTION: There is often uncertainty regarding the site of the cerebrospinal fluid (CSF) block in individual patients with hydrocephalus, leading to a significant failure rate for endoscopic third ventriculostomy (ETV) when performed for unconventional pathologies such as postmeningitic and posthaemorrhagic hydrocephalus. We describe the use of lumbar air encephalography (AEG) to refine the indications for ETV in such circumstances. METHODS: Data from AEG studies used to guide indications for ETV were collected prospectively. The technique and protocol for AEG have been modified from the historical description of the procedure in the interest of safety and to minimise discomfort. In a separate evaluation, the level of the CSF block was determined by one of the authors, who was blinded to the results of the AEG, based on conventional computerised tomographic criteria. These results are compared with those obtained from the AEG. RESULTS: Forty-five studies were performed over a 2-year period. Thirty-seven were preinterventional, the majority of which demonstrated communicating hydrocephalus. ETV performed in five cases of non-communicating hydrocephalus was successful in each. The prediction of the level of block based on CT criteria was poor. CONCLUSION: It is often difficult to determine whether hydrocephalus is communicating or not with conventional imaging in the absence of a clearly demonstrable lesional obstruction to the CSF pathways. We have found AEG helpful in excluding patients with communicating hydrocephalus from an inappropriate ETV. On the basis of our experience, we consider the modified procedure safe as long as a strict protocol is followed.


Assuntos
Derivações do Líquido Cefalorraquidiano/métodos , Hidrocefalia/diagnóstico por imagem , Hidrocefalia/cirurgia , Neuroendoscopia/tendências , Pneumoencefalografia , Análise de Variância , Humanos , Hidrocefalia/patologia , Neuroendoscopia/métodos , Estudos Prospectivos , Estudos Retrospectivos , Terceiro Ventrículo/diagnóstico por imagem , Tomografia Computadorizada por Raios X/métodos , Resultado do Tratamento , Ventriculostomia/métodos
14.
S Afr Med J ; 94(4): 293-6, 2004 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-15150945

RESUMO

BACKGROUND: Child abuse is a worldwide scourge. One of its most devastating manifestations is non-accidental head injury (NAHI). METHODS: This is a retrospective chart review of children presenting to the Red Cross Children's Hospital trauma unit with a diagnosis of NAHI over a 3-year period. RESULTS: Sixty-eight children were included in the study and 2 different groups were identified. Fifty-three per cent of the children were deliberately injured (median age 2 years), while 47% were allegedly not the intended target of the assailant (median age 9 months). The assailant was male in 65% of the intentional assaults and male in 100% of the unintentional assaults, with the intended adult victim female in 85% of the latter cases. Overall, 85% of the assaults were committed in the child's own home. CONCLUSIONS: The high proportion of cases in which a young child was injured unintentionally suggests that these infants effectively become shields in assaults committed by adults. In this context any attempts to deal with child abuse must also address the concurrent intimate partner violence.


Assuntos
Maus-Tratos Infantis , Traumatismos Craniocerebrais/epidemiologia , Violência Doméstica , Adulto , Pré-Escolar , Feminino , Humanos , Incidência , Lactente , Masculino , Estudos Retrospectivos , África do Sul/epidemiologia , Centros de Traumatologia , População Urbana
15.
Childs Nerv Syst ; 19(9): 666-73, 2003 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-12908115

RESUMO

INTRODUCTION: Decompressive craniectomy remains a controversial procedure in the treatment of raised intracranial pressure (ICP) associated with post-traumatic brain swelling. Although there are a number of studies in adults published in the literature on this topic, most commonly as a salvage procedure in the treatment of refractory raised ICP, there are few that investigate it primarily in children with head injuries. AIM: Our aim was to report the experience with decompressive craniotomy in children with severe traumatic brain injury (TBI) at the Red Cross Children's' hospital. METHODS: This study reports five patients in whom decompressive craniectomy or craniotomy with duraplasty was used as an early, aggressive treatment of raised ICP causing secondary acute neurological deterioration after head injury. The rationale was to save the patient from acute cerebral herniation and to prevent exposure to a prolonged course of intracranial hypertension. RESULTS: All patients benefited from the procedure, demonstrating control of ICP, radiological improvement and neurological recovery. Long-term follow-up was available, with outcome assessed at a minimum of 14 months after injury. DISCUSSION: The early approach to the use of decompressive craniotomy in the treatment of severe traumatic brain injury (TBI) with secondary deterioration due to raised ICP is emphasised. A favourable outcome was achieved in all of the cases presented. The potential benefit of decompressive craniectomy/craniotomy in the management of children with severe TBI is discussed.


Assuntos
Lesões Encefálicas/cirurgia , Craniotomia/métodos , Descompressão/métodos , Lesões Encefálicas/patologia , Criança , Pré-Escolar , Feminino , Seguimentos , Escala de Resultado de Glasgow , Humanos , Hipertensão Intracraniana/prevenção & controle , Pressão Intracraniana , Masculino , Tomografia Computadorizada por Raios X/métodos , Resultado do Tratamento
16.
Childs Nerv Syst ; 19(4): 217-25, 2003 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-12682756

RESUMO

INTRODUCTION: We report our preliminary experience with two cases of tuberculous meningitis (TBM) in which endoscopic third ventriculostomy (ETV) was performed to treat non-communicating hydrocephalus. For many years, the insertion of ventriculoperitoneal shunts has been the standard treatment for hydrocephalus in patients with TBM, although the indications for and timing of surgery are not uniformly accepted. Shunt insertion is associated with a high incidence of complications, particularly with long-term follow-up. An alternative treatment for hydrocephalus in this group of patients would clearly be of great benefit. The indications for ETV have increased in the last decade, and there are reports of some effectiveness of the procedure in patients with hydrocephalus due to bacterial meningitis. To our knowledge, ETV has not been described in the management of TBM. METHODS: We report the early results of our preliminary experience with ETV in two patients who presented with neurological compromise due to hydrocephalus and raised intracranial pressure. The clinical context and pre-operative investigation of these patients are presented. The emphasis is placed on the distinction between communicating and non-communicating pathologies as a guide to management options. We detail our surgical findings and the peculiar endoscopic challenges that the condition presented to us. Follow-up in these patients included clinical and investigational data suggesting early effectiveness of the procedure in converting non-communicating hydrocephalus into a communicating one, which can then be treated medically. DISCUSSION: Endoscopic third ventriculostomy is presented as a new application of a procedure accepted for other indications in the treatment of non-communicating hydrocephalus. There are particular aspects of the use of this procedure related to the unique pathology of TBM that are significantly different. We explain our rationale for endoscopy in these patients, and suggest a protocol in which endoscopy may play a role in the management of patients with raised intracranial pressure due to tuberculous hydrocephalus.


Assuntos
Endoscopia/métodos , Hidrocefalia/cirurgia , Terceiro Ventrículo/cirurgia , Tuberculose Meníngea/cirurgia , Ventriculostomia/métodos , Pré-Escolar , Humanos , Hidrocefalia/diagnóstico por imagem , Hidrocefalia/etiologia , Hipertensão Intracraniana/etiologia , Masculino , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Tuberculose Meníngea/complicações , Tuberculose Meníngea/diagnóstico por imagem
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