[Impact of working conditions at a general mechanical rubber goods plant on dental morbidity in its workers].

The impact of working conditions on dental morbidity was studied in workers from the Kazan general mechanical rubber goods (GMRG) plant. Analysis of the results of studying the prevalence of major dental diseases in the workers of the GMRG plant showed that the number of patients with caries, noncarious lesions, as well as periodontal diseases is far in excess of those in the control group. The studies, conducted in terms of the age and length of service of the examinees, corroborate the influence of adverse industrial factors on the prevalence of major dental diseases.

[The late effects of the toxic action of platinum-containing cytostatic preparations on rat progeny]. / Otdalennye éffekty toksicheskogo deistviia platinsoderzhashchikh tsitostaticheskikh preparatov na potomstvo krys.

Experiments on Wistar rats studied the state of the posterity born as a result of mating of intact females with males, who were injected with the antitumor drug platidiam one month before mating (once, intravenously, maximal tolerance dose). The pre- and postimplantation death rate did not grow in female rats mated with test males. However, the fetuses showed visceral anomalies and delayed development of skeleton. A decrease in the muscle tone, as well as ability for the training and extrapolation behavior, were observed in some newborn rat pups.

[Testicular morphology in rats in the early and late periods after platidiam administration]. / Morfologiia semennikov krys v rannie i otdalennye sroki posle vvedeniia platidiama.

The experiments performed on Wistar rats showed morphological damages of the rat testis over a one-month period after platidiam administration (4 mg/kg, one-time intravenous injection), namely a decrease in the index of spermatogenesis, in the number of normal spermatogonia, Leydig cells, and testis tubes at the 12th stage of meiosis and an increase in the number of testis tubes squamous epithelium. In the remote period (3 and 6 month after platidiam administration) the recovery of morphological and functional state of the rat testis was observed.

[Late effects of damaging action of doxorubicin on the reproductive system and progeny of rats]. / Otdalennye éffekty povrezhdaiushchego deistviia doksorubitsina na reproduktivnuiu sistemu i potomstvo krys.

The effect of doxorubicin, an anthracycline antibiotic, on the reproductive system and progeny was studied in rats 1 month after a single administration of the drug in the MID of 6.85 mg/kg. It was shown that doxorubicin induced a decrease in the number of the mature oocytes in the rat ovary and an increase in the pre- and post-implantation death rate. The rats exposed to the antibiotic 1 month before the mating with intact male rats had unchanged fertility and pregnancy. In the fetuses isolated from the female rats treated with the antibiotic, development of some parts of the skeleton appeared to be retarded. One fetus and one young rat had severe developmental anomalies in the skeletons: shorter right anterior and hind extremities and finger aplasia. The survival rate of the progeny from the female rats exposed to the antibiotic was markedly decreased. No retardation in the physical development of the progeny was observed.