RESUMO
It has been suggested that laryngeal basement membrane (LBM) thickening is a pathognomonic postmortem marker for sudden infant death syndrome (SIDS) and is not seen in other causes of explained sudden infant death. To test this hypothesis, we evaluated longitudinal sections of the right hemilarynx taken through the midpoint of the true vocal cord from 129 SIDS cases and 77 postneonatal sudden infant death controls. Using a five-point semi-quantitative scale, maximum LBM thickness (LBMT) for SIDS cases and controls was not statistically different (mean, 2.39 + 0.69 and 2.40 + 0.77, respectively). Likewise, scores based on the average thickness along the entire basement membrane (i.e., "average" score), were not found to be different between SIDS cases and controls. Average and maximum LBMT increased with age in both SIDS cases and controls and were not different between SIDS cases and controls within each age interval. Similar trends in the distribution of maximum and average LBMTs were found between black and Hispanic SIDS and controls; the number of white/non-Hispanic infants was too low for meaningful comparisons. Maximum and average LBMTs were not different in SIDS cases and controls exposed to environmental tobacco compared with unexposed infants. The LBMTs also increased significantly with body weight and length in both SIDS cases and controls. Finally, there were no differences in LBMT in infants intubated prior to death compared with those who were not intubated. From these data, we conclude that LBMT is not pathognomonic of SIDS, is present or absent with equal frequency in SIDS and controls, increases with postnatal age, and does not correlate with passive smoke exposure. Therefore, LBMT should not be used to diagnose SIDS.
Assuntos
Laringe/patologia , Morte Súbita do Lactente/diagnóstico , Membrana Basal/patologia , Biomarcadores , Chicago , Feminino , Humanos , Lactente , Mortalidade Infantil , Masculino , Morte Súbita do Lactente/patologiaAssuntos
Transfusão de Sangue/legislação & jurisprudência , Viabilidade Fetal , Consentimento Livre e Esclarecido/legislação & jurisprudência , Defesa do Paciente/legislação & jurisprudência , Recusa do Paciente ao Tratamento/legislação & jurisprudência , Adulto , Cristianismo , Feminino , Humanos , Competência Mental , Avaliação das Necessidades , Gravidez , Religião e Medicina , Governo Estadual , Estados UnidosRESUMO
We report two cases of unexpected death due to metastatic gestational choriocarcinoma and provide a review of the literature regarding these neoplasms. Our cases illustrate the extreme importance of medical follow-up of patients after an ectopic pregnancy or therapeutic abortion.
Assuntos
Coriocarcinoma/patologia , Neoplasias Uterinas/patologia , Aborto Terapêutico/efeitos adversos , Adulto , Coriocarcinoma/etiologia , Evolução Fatal , Feminino , Humanos , Gravidez , Gravidez Ectópica/complicações , Gravidez Ectópica/cirurgia , Neoplasias Uterinas/etiologiaRESUMO
Colloid cysts of the third ventricle are rare central nervous system tumors that are a recognized cause of unexpected death in young, otherwise healthy adults and children. We report three adults and one child who died from colloid cysts of the third ventricle. Our report illustrates the difficulties of diagnosing these tumors premortem.