RESUMO
The paper summarizes the results of in vitro and in vivo studies that have proved biocompatibility and medical safety of Ta and Ti-Nb-Ta-bases alloys. According to some in vitro data Ti-Nb-Ta-based alloy possesses certain advantages when comparing to Ta-based. In particular, it contributes to elevation of viability of cellular elements and to definite increase of their adhesive potential.
Assuntos
Ligas/uso terapêutico , Ligas Dentárias/uso terapêutico , Implantação Dentária , Nióbio , Tantálio , Titânio , Ligas/efeitos adversos , Animais , Células Cultivadas , Ligas Dentárias/efeitos adversos , Fibroblastos , Teste de Materiais , CoelhosRESUMO
On 8 rabbits with experimentally produced critical defects of calvarium plastics of the defects was performed by bioengineering constructions based upon porous polytetrafluoroethylene with multifunctional nanostructured non-resorbable cover Ti-C-Ca-P-O-N and autogenic stromal cells from adipose tissue (the main group -4 rabbits). In the reference group (4 rabbits) the defects were repaired by abiologic implants. At the terms of 3 and 6 months in the main group under implants the formation of the full value bone regenerate was seen in the region of calvarium defects. In the reference group in the bone defects the regenerate from rough fibrose connective tissue was formed.
Assuntos
Tecido Adiposo/citologia , Bioengenharia , Regeneração Óssea , Células-Tronco Multipotentes/transplante , Politetrafluoretileno/química , Crânio/cirurgia , Células Estromais/transplante , Engenharia Tecidual/métodos , Animais , Separação Celular , Células-Tronco Multipotentes/citologia , Nanoestruturas/química , Coelhos , Crânio/lesões , Crânio/fisiologia , Células Estromais/citologiaRESUMO
The authors developed new material based upon polytetrafluoroethylene (Teflon) with nanostructured metal and ceramic coatings. The task was formulated to study integrating potential of different chemical composition surfaces of intraosseous implants using Teflon with the mentioned above coatings as the experimental model. In experiments on rats using histomorphologic criterion there were compared implants from Teflon with Ti-, Ti-Ca-P-C-O-N- and Ti-Ca-Mn-K-C-O-N-coatings and Teflon without coating as the group for reference. It was shown that new experimental implant model based upon Teflon with different nanostructured coatings opened the possibility to profound investigation of interface contact substrate of metal (ceramic) surface with surrounding tissue structures. Optimal results upon the osteointegration criterion were received with Teflon + Ti-Ca-P-C-O-N-coating.
