RESUMO
The electrophoretic behavior of the 111In-DTPA radiopharmaceutical has been investigated. The stability constant, diffusion coefficient and effective charge of the complex as well as the temperature dependence of the electrophoretic mobility were determined. No-carrier-added 111In with high specific activity was used in the electrophoretic experiments in ultramicroconcentrations (10(-9)M).
Assuntos
Radioisótopos de Índio/química , Ácido Pentético/análogos & derivados , Compostos Radiofarmacêuticos/química , Interpretação Estatística de Dados , Difusão , Estabilidade de Medicamentos , Eletroforese/métodos , Concentração de Íons de Hidrogênio , Concentração Osmolar , Ácido Pentético/química , Distribuições Estatísticas , Temperatura , Fatores de TempoRESUMO
A new method of the perturbed angular gamma-gamma-correlation (PAC) measurements was developed using one HPGe detector only (1-PAC). For quantifying the perturbation factor, the ratio R gamma 1 + gamma 2 of the summing peak composed of two cascade gamma-rays (the perturbation-affected parameter) to the summing peak composed of one gamma-ray and one X-ray (the perturbation non-affected parameter) was used. This method was demonstrated for the radionuclides 111In and 111mCd, identifying the chemical status of the radionuclides in aqueous solutions.
RESUMO
A new method of 111In separation from a silver target irradiated with 30 MeV alpha-particles is described. The 111In isolation from Ag and Cd is based on its co-precipitation with La(OH)3. The 111In separation from La(III) has been performed by the method of ion-exchange chromatography. A multi-stage purification technique was developed that allows the production of 111In radiochemicals in which the part of impurities of di-, tri-valent metal atoms is negligible.