RESUMO
PURPOSE: Reports of direct current shifts at the onset of scalp-recorded seizures prompted us to inspect depth-recorded seizures for the presence of similar slow potential shifts at the onset of the seizure to determine whether slow potential (SP) shifts actually occur at the onset of depth-recorded seizures and if these shifts can facilitate localization of the seizure focus. METHODS: With the low frequency filter "opened" (LLF=0.1 Hz, HLF=70 Hz, 3 dB/octave), 32 seizures recorded with hippocampal depth and subdural electrodes were visually inspected to identify an SP shift at the onset of the seizure. A seizure was considered as having an SP shift when the slow potential waveform was > 1.5 sec in duration and > 100 microV in amplitude. Seizures were obtained from 5 subjects; 4 underwent epilepsy surgery (3=Engel I, 1=Engel II) and one received VNS. SP shift duration, peak voltage and polarity were measured for each seizure. The ability to identify seizures based on SP shift configuration was also evaluated. RESULTS: In 84% of the seizures, ictal onset was associated with a localized SP shift. Shift duration ranged from 1.5 sec to 11.5 sec (96% > 2 sec, 62% > 5 sec). The maximum shift ranged from 139 microV to 2305 microV (mean = 1123 microV, SD = 660 microV). In all the seizures, polarity was positive at the point of maximum shift. By visually examining the SP shift, seizures could be identified as originating from the same focus or from different foci. CONCLUSIONS: The onset of depth-recorded seizures appears to be commonly associated with a localized positive SP shift. An SP shift at the onset of depth-recorded seizures is likely to be a useful visual aid for localizing electrographic seizure onset.
Assuntos
Eletroencefalografia/métodos , Epilepsia do Lobo Temporal/diagnóstico , Epilepsia do Lobo Temporal/fisiopatologia , Epilepsia/diagnóstico , Epilepsia/fisiopatologia , Hipocampo/fisiopatologia , Potenciais de Ação/fisiologia , Adulto , Eletrodos/normas , Eletroencefalografia/instrumentação , Epilepsia/etiologia , Epilepsia do Lobo Temporal/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Tempo de Reação/fisiologia , Fatores de TempoRESUMO
It has become abundantly clear that standards of recording clinical terms in human-readable, computer-processable format are indispensable. Controlled medical terminology is the missing link in health information standards (in fact, medical terminology can be viewed as the mother of all standards); its absence interferes with the business of healthcare and impedes the core processes of healing and maintaining health. Medicine has lacked the controlled common medical vocabulary that would enable universal sharing of data at the point of care and ensure reliable information for determining health intervention effectiveness. Simple clinical and code content alone has proven insufficient for healthcare enterprises to successfully manage the terminology problem; the "lexical runtime engine," formerly called a vocabulary server (VOSER), which manages the vocabulary ontology and serves up the relevant vocabulary to users of applications in the clinical environment, has recently become a reality.
Assuntos
Sistemas de Gerenciamento de Base de Dados , Aplicações da Informática Médica , Sistemas Computadorizados de Registros Médicos , Terminologia como Assunto , Vocabulário Controlado , Humanos , Armazenamento e Recuperação da Informação , Garantia da Qualidade dos Cuidados de Saúde , Design de SoftwareRESUMO
A number of clinical coding and vocabulary schemes are in use in healthcare enterprises today. Most of them are weak in light of the qualities that characterize adequate controlled medical terminologies, as outlined in Part One of this review. Here we look at the major code and terminology sets with a critical eye, as well as suggest practical steps to enable health industry information system purchasers and users to move forward with their effort to use common terminology to improve the quality, service, and knowledge in their enterprise.
Assuntos
Aplicações da Informática Médica , Sistemas Computadorizados de Registros Médicos/classificação , Terminologia como Assunto , Vocabulário Controlado , Indexação e Redação de Resumos , Controle de Formulários e Registros , Humanos , Garantia da Qualidade dos Cuidados de Saúde , Estados UnidosRESUMO
PURPOSE: To assess the effect of vagus nerve stimulation (VNS) on interictal epileptiform activity in the human hippocampus. Clinical studies have established the efficacy of vagus nerve stimulation in patients with epilepsy (VNS Study Group, 1995), although the electrophysiologic effects of VNS on the human hippocampus and mesial temporal lobe structures remain unknown. METHODS: We report a case study in which a patient with an implanted VNS underwent intracranial electrode recording before temporal lobectomy for intractable complex partial seizures. Epileptiform spikes and sharp waves were recorded from a depth electrode placed in the patient's left hippocampus. Spike frequencies and sharp-wave frequencies before and during VNS were compared using both a 5- and a 30-Hz stimulus. Different stimulation rates were tested on different days, and all analyses were performed using a Student's t test. RESULTS: We found no significant differences in spike frequency between baseline periods and stimulation at 5 and 30 Hz. In contrast, stimulation at 30 Hz produced a significant decrease in the occurrence of epileptiform sharp waves compared with the baseline, whereas stimulation at 5 Hz was associated with a significant increase in the occurrence of epileptiform sharp waves. CONCLUSIONS: VNS produces a measurable electrophysiologic effect on epileptiform activity in the human hippocampus. Although a clinical response to VNS did not occur in our patient before surgery, 30-Hz VNS suppressed interictal epileptiform sharp waves that were similar in appearance to those seen during the patient's actual seizures. In contrast, 5-Hz stimulation appeared to increase the appearance of interictal sharp waves.
Assuntos
Terapia por Estimulação Elétrica/métodos , Eletroencefalografia/estatística & dados numéricos , Epilepsia/terapia , Hipocampo/fisiopatologia , Nervo Vago/fisiologia , Adolescente , Terapia por Estimulação Elétrica/instrumentação , Eletrodos Implantados , Eletroencefalografia/métodos , Epilepsia/diagnóstico , Epilepsia/fisiopatologia , Epilepsia do Lobo Temporal/diagnóstico , Epilepsia do Lobo Temporal/fisiopatologia , Epilepsia do Lobo Temporal/terapia , Desenho de Equipamento , Humanos , Masculino , Técnicas Estereotáxicas , Espaço Subdural , Lobo Temporal/fisiopatologiaRESUMO
Postictal EEG suppression and slowing recorded with scalp electrodes in patients with partial epilepsy is often maximal over the cortical area of ictal onset. The aim of this study was to determine whether a quantitative relationship exists between immediate postictal EEG suppression and hippocampal atrophy. Immediate postictal EEG was analyzed in 31 scalp-recorded seizures obtained from 8 patients who underwent temporal lobectomy with seizure-free outcomes (2 left, 6 right). Quantitative EEG analysis was performed using a temporal power asymmetry index for each frequency band. The hippocampal asymmetry (left-to-right ratio) based on T1- and T2-weighted MR images was determined by hippocampal volumetric analysis. The relationship between the average temporal power asymmetry index and either T1 or T2 hippocampal asymmetry ratio was assessed for each frequency band using Pearson's correlation coefficient. Only correlations of the temporal power asymmetry index with T1 hippocampal asymmetry were significant for the total bands (r = 0.768, P < 0.026) and 8-bands (r = 0.728, P < 0.041). The findings suggest that a quantitative relationship exists between postictal EEG suppression in the 6-frequency band and hippocampal atrophy in temporal lobe epilepsy.
Assuntos
Epilepsia do Lobo Temporal/fisiopatologia , Hipocampo/patologia , Adulto , Atrofia , Eletroencefalografia , Epilepsia do Lobo Temporal/patologia , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Lobo Temporal/patologia , Lobo Temporal/fisiopatologiaRESUMO
The first comprehensive epilepsy surgery center in Louisiana was established in 1990 at the Louisiana State University Medical Center in New Orleans by the Departments of Neurology and Neurosurgery. The center performs a wide variety of diagnostic tests essential for the medical and surgical treatment of epilepsy including EEG and video monitoring, quantitative hippocampal MRI volumetry, ictal SPECT brain scanning, intracranial evoked potential and subdural stimulation functional mapping, neuropsychological evaluations, and intracarotid amobarbital (Wada) language and memory localization. Surgical interventions include (1) the placement of subdural strip and grid electrodes, depth electrodes, and foramen ovale electrodes, (2) temporal lobectomies, and (3) frontal, temporal, parietal, and occipital lobe resections. From August 1990 through October 1995 41 patients with medically intractable seizures underwent neurosurgical procedures for epilepsy. Thirty-five patients had resective surgery, while six had only intracranial monitoring by subdural or intracerebral electrodes. The surgical outcomes thus far compare favorably with those of other established centers in North America.
Assuntos
Epilepsia/diagnóstico , Epilepsia/cirurgia , Avaliação de Processos e Resultados em Cuidados de Saúde , Adolescente , Adulto , Artéria Carótida Interna/diagnóstico por imagem , Criança , Estimulação Elétrica , Eletroencefalografia , Feminino , Humanos , Louisiana , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Monitorização Intraoperatória , Monitorização Fisiológica , Testes Neuropsicológicos , Complicações Pós-Operatórias , Avaliação de Programas e Projetos de Saúde , Radiografia , Tomografia Computadorizada de Emissão de Fóton Único , Gravação em VídeoRESUMO
Sodium and water homeostasis is abnormal in hemodialysis (HD) patients, however, the distribution of the excess fluid (extracellular vs. intracellular) has not been fully characterized. We studied the distribution of fluid using bioimpedance spectroscopy to determine if HD patients have an excess of fluid in any specific compartment relative to controls. Dual-energy x-ray absorptiometry was used to measure lean body mass and bone mineral content. The resistive index (RI) for extracellular water volume (RIECW), was significantly increased in patients pre-HD when corrected for bone mineral content (RIECW:BMC) (pre-HD, 19.0 +/- 3.3; controls, 15.8 +/- 1.7 cm2-ohms(-1)-kg -1; P < 0.01). This value decreased to the control range following HD (15.2 +/- 2.5 cm2-ohms(-1)-kg(-1). The intracellular water volume to bone mineral content (RIICW:BMC) was not different between controls and HD patients. These data suggest that hemodialysis patients carry their excess fluid volume primarily in the extracellular compartment and that bioimpedance spectroscopy coupled with a stable measure of lean tissue such as bone mineral content can determine the degree of relative excess hydration.
Assuntos
Falência Renal Crônica/fisiopatologia , Diálise Renal , Equilíbrio Hidroeletrolítico/fisiologia , Absorciometria de Fóton , Adulto , Análise de Variância , Densidade Óssea , Doença Crônica , Impedância Elétrica , Feminino , Humanos , Falência Renal Crônica/terapia , Masculino , Pessoa de Meia-Idade , Monitorização Fisiológica , Água/metabolismoRESUMO
To determine the occurrence and clinical implications of electroencephalographic (EEG) abnormalities in patients with acute lacunar infarction, we conducted a single-blinded EEG study in 55 patients. Twenty-nine (53%) had mild EEG abnormalities, which were focal and ipsilateral to the side of infarction in 7 patients (13%). Abnormalities were more common in patients with evidence of a prior stroke (10 of 12 patients, 83%). However, 43% (16 of 37 patients) of those without historical or radiologic evidence of a prior stroke also had mild EEG abnormalities. This represents a higher incidence of routine EEG abnormalities in lacunar infarction than is generally assumed. Indeed, these findings are more consistent with recent quantitative EEG studies that consistently have shown high rates of abnormalities in lacunar infarction. We did not find major EEG abnormalities, such as continuous or nearly continuous focal delta activity, in any patient with first lacunar infarction. We conclude that within the first 48 h after a first ischemic infarction, when computed tomography often fails to show abnormalities, an EEG that shows lateralized major abnormalities is useful in excluding the diagnosis of either lacunar infarction or infarction limited to the brain stem. Mild abnormalities occur more often than previously thought in lacunar infarction and do not exclude this diagnosis.
Assuntos
Infarto Cerebral/fisiopatologia , Eletroencefalografia , Idoso , Idoso de 80 Anos ou mais , Infarto Cerebral/diagnóstico , Estudos de Avaliação como Assunto , Humanos , Imageamento por Ressonância Magnética , Método Simples-Cego , Tomografia Computadorizada por Raios XRESUMO
In this article we describe the implementation of a linearly weighted average reference montage. This montage differs from the commonly used source derivation montage in that the reference includes all the scalp electrodes of the 10-20 system; and it differs from all other montages implemented thus far in that the weighting of the reference electrodes is based on directly measured interelectrode distances. Using EEG and computer generated signals we have been able to demonstrate that the weighted average reference montage combines topographic selectivity and accuracy in the display of both focal and regional background changes. In comparison to the source derivation montage, ectopic peaks and troughs of localized potential fields are less prominent and interhemispheric symmetry is better preserved. In comparison to the common average reference montage the frequent prominent ectopic displacement of high amplitude (e.g., vertex waves) or widespread potentials (e.g., alpha background activity) is suppressed. We believe that the spatial filtering characteristics of the weighted average reference montage, which are intermediate between those of the common average reference montage and the source derivation and Laplacian montages, will make it a useful alternative for topographic analysis. Our results also indicate that actual scalp measurements should be used to calculate reference electrode weighting factors because such measurements yield values that are substantially different from those derived from other methods of estimation presented thus far. A weighted average montage derived from pooled scalp measurements can be easily implemented using the weighting factors provided herein.
Assuntos
Encéfalo/fisiologia , Eletroencefalografia/métodos , Adulto , Mapeamento Encefálico , Humanos , Pessoa de Meia-Idade , Processamento de Sinais Assistido por ComputadorRESUMO
We evaluated the sensitivity of continuous quantitative EEG in 11 patients with subarachnoid hemorrhage (SAH). We correlated compressed spectral array (CSA) and trend analysis (TA) of total power (1-30 Hz), frequency centroid (1-30 Hz), alpha ratio and percent delta power with clinical and radiological findings. For all ischemic events (n = 11), the most sensitive TA parameter was a change in total power (91%), followed by changes in alpha ratio (64%), frequency centroid (55%), and percent delta (45%). Comparable CSA features were changes in power (44%) and slowing (39%). Total power and frequency varied independently. In 4 cases, EEG findings on TA appeared before clinical changes. Continuous quantitative EEG may be useful for monitoring and predicting ischemia following SAH. TA of individual EEG parameters is more sensitive than CSA, and total power is the most sensitive.
Assuntos
Eletroencefalografia , Aneurisma Intracraniano/fisiopatologia , Hemorragia Subaracnóidea/fisiopatologia , Adulto , Idoso , Humanos , Aneurisma Intracraniano/complicações , Ataque Isquêmico Transitório/fisiopatologia , Pessoa de Meia-Idade , Hemorragia Subaracnóidea/etiologiaRESUMO
We studied the responses to diffuse and patterned stroboscopic light stimulation prospectively in 49 individuals during acute alcohol withdrawal prior to pharmacologic treatment. Photomyogenic responses (PMR) occurred in only two (4%) of those tested, and photoparoxysmal responses (PPR) never occurred. These findings suggest that PMR occur far less often during alcohol withdrawal than previously thought and that PPR may not be a direct manifestation of alcohol withdrawal.
Assuntos
Encéfalo/fisiopatologia , Etanol/efeitos adversos , Estimulação Luminosa , Síndrome de Abstinência a Substâncias/fisiopatologia , Adulto , Eletroencefalografia , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
A blind analysis of 56 EEGs with triphasic wave patterns was performed to determine the diagnostic specificity of individual electrographic features. EEG and clinical variables analyzed included longitudinal topography, phase lags, symmetry, background activity, reactivity, longitudinal bipolar phase reversal sites, responses to photic stimulation and mental status at the time of recording. The only statistically significant finding for any of the diagnostic groups tested was the presence of severe background slowing in cases of hepatic encephalopathy (P less than 0.001). We found no evidence to suggest that other features may contribute to a more highly characteristic pattern for hepatic encephalopathy. None of the features studied reliably distinguished hepatic encephalopathy from other forms of metabolic encephalopathy.
Assuntos
Encefalopatias/diagnóstico , Eletroencefalografia , Encefalopatia Hepática/diagnóstico , Adulto , Idoso , Idoso de 80 Anos ou mais , Humanos , Entrevista Psiquiátrica Padronizada , Pessoa de Meia-Idade , Estimulação LuminosaRESUMO
We describe a new approach for assessing EEG background symmetry by topographic display of spectral band amplitude. Asymmetry is expressed as a percentage in much the same way that routine EEG symmetry comparisons are made. Spectral graphs of each channel are simultaneously displayed to facilitate interpretation. This method enhances the use of topographic mapping as an adjunct to conventional EEG interpretation.
Assuntos
Mapeamento Encefálico , Eletroencefalografia , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
We have reviewed the principal electroencephalographic findings in focal cerebral lesions and indicated practical applications for EEG in the era of CT. CT has restricted the use of EEG for detecting and localizing brain lesions, but it has also allowed EEG to focus appropriately on physiologic rather than anatomic issues. Clinically important focal electroencephalographic abnormalities may occur in the absence of CT lesions, and clinicians must understand the implications of such dissociations.