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1.
Clin Cosmet Investig Dermatol ; 16: 2757-2762, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37814676

RESUMO

Background: Dry scalp conditions affect a significant portion of the population, including children. Emerging evidence indicates the potential for improvement of atopic symptoms through altering the skin microbiome. Therefore, a topical treatment consisting of probiotic extracts, honey, turmeric, and vitamin B12 was manufactured to improve dry scalp symptomology through sustained balance of the microbiome. Purpose: This interventional clinical study aims to determine the safety and efficacy of the topical treatment in reducing dry scalp symptomology in children 1-17 years old with dry scalp symptoms. Methods: Participants applied the topical dry scalp treatment 2-3 times per week for two weeks. Safety and efficacy of the topical treatment was determined through physician assessment using the validated Investigator's Global Assessment (IGA) scale and the Total Severity Scale (TSS) during pre- and post-treatment clinic visits as well as parent reports at baseline, 1-week midpoint, and 2-week exit. Results: Use of the topical treatment was associated with reduced symptoms of itchiness, dryness, irritation, and flakiness in children. The average IGA score was 3.0 at baseline and 2.0 after treatment, corresponding to a score difference of 1.0 (p < 0.001, 95% CI: 0.7, 1.2). The TSS score difference was 1.9 (p < 0.001, 95% CI: 1.4, 2.4). The total parent-reported scalp severity score decreased from 16.6 (95% CI: 14.8, 18.4) to 12.4 (p < 0.001, 95% CI: 11.0, 13.7) at 2-week exit. Discussion: Study results mirror those reported in a study conducted in adults and point to the safety and efficacy of this natural topical treatment in reducing dry scalp symptomology in children. Based on our data, the combination of probiotic extracts and other anti-inflammatory ingredients appears to improve overall scalp health and appearance, though further studies will need to be conducted to further elucidate the link between clinical improvement and a balanced scalp microbiome.

2.
J Food Allergy ; 4(3): 172-180, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37502300

RESUMO

Background: Current COVID-19 and influenza vaccination-related knowledge, attitudes, and behaviors remain poorly understood among US children with food allergy-and particularly those from non-Hispanic Black, Latinx, and lower income backgrounds who bear a disproportionate burden by allergic disease. These data are especially relevant due to historical vaccine hesitancy in children with food allergy and an initial contraindication for those with severe allergic reactions to be vaccinated against COVID-19. Objective: We sought to characterize COVID-19 and influenza vaccination-related knowledge, attitudes, and behaviors in a racially, ethnically, and socioeconomically diverse longitudinal cohort of caregiver-child dyads with IgE-mediated food allergy. Methods: We leveraged the NIH-supported FORWARD cohort, consisting of non-Hispanic White, non-Hispanic Black, and Hispanic/Latinx children diagnosed with food allergy to assess COVID-19 testing, vaccination, and influenza vaccine concern and utilization through administering a one-time IRB-approved survey. Results: Non-Hispanic Black participants were less likely than Non-Hispanic White participants to be vaccinated (OR=0.25, 95%CI:0.08-0.75) or tested (OR=0.33, 95%CI:0.13-0.85) for COVID-19 and have the intention to vaccinate their children for influenza (OR=0.42; 0.18-0.98). Over one third of participants reported that they believe their child is at greater risk of complications from COVID-19 vaccination due to food allergy. There were racial/ethnic disparities in the belief that COVID vaccines contain allergenic ingredients such that more Hispanic/Latinx (37%) and Black (37%) participants than White (22%) participants reported this belief (p=.02). Conclusion: The present findings of disparities in vaccination-related knowledge, attitudes, and behaviors across racial/ethnic, and household income strata suggest that initial reports of COVID-19 vaccination hesitancy within the population with food allergy may be further exacerbated by well-documented, racial, ethnic, and socioeconomic differences in vaccine hesitancy, potentially leading to a greater infectious disease burden in these vulnerable populations. This highlights a need for targeted education and outreach among members of these communities who are living with food allergy.

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