Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros











Base de dados
Tipo de estudo
Intervalo de ano de publicação
1.
Physiol Res ; 65(Suppl 5): S673-S682, 2016 12 22.
Artigo em Inglês | MEDLINE | ID: mdl-28006949

RESUMO

Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder, associated with autonomic dysregulation. However, the pathomechanism leading to autonomic abnormalities is still unclear. The aim of this study was to assess autonomic nervous system (ANS) activity during baseline in homogenous group of autistic children using electrodermal activity (EDA), as an index of sympathetic activity and short-term heart rate variability (HRV) reflecting predominantly cardiac vagal control. Fifteen ASD boys and 15 healthy age-matched boys at the age of 7-15 years were examined. The continuous EDA and ECG were recorded during resting phase in a supine position. Evaluated parameters: EDA amplitude (microS), RR interval, spectral power, peak frequency and power spectral density in low (LF-HRV: 0.04-0.15 Hz) and high-frequency (HF-HRV: 0.15-0.4 Hz) bands of HRV spectral analysis. In ASD group we found significantly shortened RR intervals (729+/-20 ms vs. 843+/-30 ms, p=0.005), lower mean EDA (0.66+/-0.13 microS vs. 1.66+/-0.42 microS, p=0.033), reduced spectral activity and power spectral density in HF-HRV compared to controls (2.93+/-0.12 ms(2) vs. 3.38+/-0.10 ms(2), p=0.01; 4.12+/-0.10 ms(2)/Hz vs. 4.56+/-0.11 ms(2)/Hz, p=0.008, respectively). We suggest that impairment in resting autonomic regulation associated with ASD could represent an important pathomechanism leading to potential cardiovascular complications in ASD.


Assuntos
Nível de Alerta/fisiologia , Transtorno do Espectro Autista/diagnóstico , Transtorno do Espectro Autista/fisiopatologia , Sistema Nervoso Autônomo/fisiopatologia , Frequência Cardíaca/fisiologia , Adolescente , Criança , Humanos , Masculino
2.
Int J Biol Macromol ; 49(5): 1046-50, 2011 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-21906620

RESUMO

An algal extracellular biopolymer (over 8.5 × 10(5)Da) composed of carbohydrates (52%) and protein (∼13%) has been isolated from a red alga Rhodella grisea growing in natural conditions by concentration of water medium, alcohol precipitation, dialysis and freeze-drying. This mucilagineous biopolymer contained xylose and its 3-O- and 4-O-methyl derivatives (∼63%), galactose (∼12%), glucuronic acid (11-12%), glucose (∼5%), rhamnose (∼4%), fucose (∼3-4%) and low content of others accompaning sugars. When tested on the citric acid-induced cough and reactivity of airways smooth muscle in vivo in the test system guinea pigs, this biopolymer assigned a significant cough suppressing effect. The reactivity of airways smooth muscle was not affected indicating that expectoration effect was not suppressed by biopolymer application, which is important from the pharmacological point of view.


Assuntos
Biopolímeros/administração & dosagem , Hiper-Reatividade Brônquica/prevenção & controle , Tosse/tratamento farmacológico , Extratos Vegetais/administração & dosagem , Proteoglicanas/administração & dosagem , Sistema Respiratório/efeitos dos fármacos , Rodófitas/química , Administração por Inalação , Administração Oral , Resistência das Vias Respiratórias/efeitos dos fármacos , Animais , Antitussígenos , Biopolímeros/química , Biopolímeros/isolamento & purificação , Ácido Cítrico/efeitos adversos , Tosse/induzido quimicamente , Tosse/fisiopatologia , Liofilização , Ácido Glucurônico/química , Cobaias , Masculino , Monossacarídeos/química , Músculo Liso/efeitos dos fármacos , Músculo Liso/fisiopatologia , Extratos Vegetais/química , Extratos Vegetais/isolamento & purificação , Pletismografia , Proteoglicanas/química , Proteoglicanas/isolamento & purificação , Reflexo/efeitos dos fármacos , Reflexo/fisiologia , Sistema Respiratório/fisiopatologia , Viscosidade
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA