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1.
Pathologe ; 35(5): 456-61, 2014 Sep.
Artigo em Alemão | MEDLINE | ID: mdl-25142043

RESUMO

Poromas were originally classified as eccrine tumors which predominantly consist of poroid ductal cells and differentiate in the direction of sweat gland ducts. However, there have now been many reports on poromas with additional differential characteristics differentiating in the direction of sebaceous and/or apocrine glands and/or hair follicles. These tumors have been termed apocrine poromas. Multilineage differentiation within a poroma can be explained by the embryological association of the sweat duct with the so-called folliculo-sebaceous-apocrine unit. The clinical and histopathological features of apocrine poromas are reviewed in comparison to classical eccrine poromas by taking into account seven own cases of apocrine poroma and a review of the literature. It is important for histopathologists not to confuse apocrine poroma with other tumors with multilineage differentiation. Apocrine poroma needs to be distinguished from sebaceoma and from basal cell carcinoma with sebaceous differentiation, in particular, because these tumors have therapeutic consequences for the patient. The main histopathological differences between apocrine poroma, sebaceoma and basal cell carcinoma with sebaceous differentiation are explained.


Assuntos
Transformação Celular Neoplásica/patologia , Poroma/patologia , Neoplasias das Glândulas Sudoríparas/patologia , Carcinoma Basocelular/classificação , Carcinoma Basocelular/patologia , Transformação Celular Neoplásica/classificação , Diagnóstico Diferencial , Humanos , Invasividade Neoplásica , Poroma/classificação , Poroma/diagnóstico , Pele/patologia , Neoplasias das Glândulas Sudoríparas/classificação , Neoplasias das Glândulas Sudoríparas/diagnóstico , Glândulas Sudoríparas/patologia
2.
Hautarzt ; 61(3): 250-4, 2010 Mar.
Artigo em Alemão | MEDLINE | ID: mdl-20127299

RESUMO

Epithelioma cuniculatum (EC) belongs to the category of verrucous carcinomas. Invasiveness and rate of metastasis are low, but there is a high risk of local recurrence. In cases of long-standing processes with formation of exophytic, malodorous tumors with jagged edges that do not respond to conventional therapy, consideration should already be given to EC upon visual inspection. The diagnosis is always established by histological examination. The standard treatment of EC is extensive excision of the tumor with micrographic margin control.


Assuntos
Cotos de Amputação/patologia , Cotos de Amputação/cirurgia , Carcinoma Verrucoso/patologia , Carcinoma Verrucoso/cirurgia , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade
3.
Eur J Med Res ; 14: 516-9, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-20149984

RESUMO

BACKGROUND: There is an unmet medical need for simplified antiretroviral therapy regimens to improve patient's compliance and quality of life. The purpose of this study was to evaluate the efficacy and safety of a once-daily regimen with Tenofovir (TDF), Emtricitabine (FTC) and Nevirapine (NVP) for adult patients with HIV-1 infection. METHODS: 70 patients were enrolled in a prospective, multicenter, non-randomized, single arm, open-label cohort study. Patients were either naive or had problems with their current ART and needed to be changed to another regimen. Daily drug dosage was 300 mg Tenofovir, 200mg Emtricitabine and 400 mg Nevirapine once daily. Follow-up was performed over 72 weeks. RESULTS: After 72 weeks, the regimen was still continued by 52 patients (74,3%). Of these, 44 patients (84,6%) had a viral load below detection limit. The median viral load had decreased by 2,5 log and the median CD4 cell count had increased by 44,8%. Most side-effects occurred at an early stage during the study. Resistances were rare (only two resistances were considered as newly developed) and occurred rather late during the study. CONCLUSION: A once-daily regimen of Tenofovir, Emtricitabine and Nevirapine is an attractive treatment option since it is safe, effective, and well tolerated.


Assuntos
Adenina/análogos & derivados , Fármacos Anti-HIV/administração & dosagem , Desoxicitidina/análogos & derivados , Infecções por HIV/tratamento farmacológico , HIV-1 , Nevirapina/administração & dosagem , Organofosfonatos/administração & dosagem , Adenina/administração & dosagem , Adenina/efeitos adversos , Adenina/uso terapêutico , Adulto , Idoso , Fármacos Anti-HIV/efeitos adversos , Fármacos Anti-HIV/uso terapêutico , Desoxicitidina/administração & dosagem , Desoxicitidina/efeitos adversos , Desoxicitidina/uso terapêutico , Quimioterapia Combinada , Emtricitabina , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Nevirapina/efeitos adversos , Nevirapina/uso terapêutico , Organofosfonatos/efeitos adversos , Organofosfonatos/uso terapêutico , Estudos Prospectivos , Tenofovir , Resultado do Tratamento
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