Digital tomosynthesis in breast imaging.

PURPOSE: To describe and evaluate a method of tomosynthesis breast imaging with a full-field digital mammographic system. MATERIALS AND METHODS: In this tomosynthesis method, low-radiation-dose images were acquired as the x-ray source was moved in an arc above the stationary breast and digital detector. A step-and-expose method of imaging was used. Breast tomosynthesis and conventional images of two imaging phantoms and four mastectomy specimens were obtained. Three experienced readers scored the relative lesion visibility, lesion margin visibility, and confidence in the classification of six lesions. RESULTS: Tomosynthesis image-reconstruction algorithms allow tomographic imaging of the entire breast from a single arc of the x-ray source and at a radiation dose comparable with that in single-view mammography. Except for images of a large mass in a fatty breast, the tomosynthesis images were superior to the conventional images. CONCLUSION: Digital mammographic systems make breast tomosynthesis possible. Tomosynthesis may improve the specificity of mammography with improved lesion margin visibility and may improve early breast cancer detection, especially in women with radiographically dense breasts.

Optical detection of ultrasound with a microchip laser.

A novel optical ultrasonic detector that relies on frequency modulation of a microchip laser is proposed and demonstrated. When the laser is placed in a time-varying acoustic field, the microchip laser cavity length is periodically modulated, creating a frequency-modulated optical output in which the frequency shift is linearly proportional to the acoustic-wave amplitude. With a confocal Fabry-Perot slope filter and a Nd:YAG microchip laser operating at 1.06 microm, a detector response of 7.5 MHz/kPa was measured at an acoustic frequency of 7.75 MHz. A one-dimensional acoustic model is developed to explain the observed detector performance.