1.
N Engl J Med
; 332(26): 1791; author reply 1791-2, 1995 Jun 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7760906
2.
Am J Med
; 83(4B): 55-9, 1987 Oct 30.
Artigo
em Inglês
| MEDLINE
| ID: mdl-3318430
RESUMO
Nabumetone is a new nonsteroidal anti-inflammatory agent. Therapy with nabumetone 1,000 mg given at bedtime was compared with naproxen 250 mg given twice daily in a prospective double-blind study of patients with rheumatoid arthritis. Both drugs were found to be efficacious in a comparable fashion. Both drugs were well tolerated in terms of patient withdrawal rates, which were 5 and 8 percent, respectively. Gastrointestinal side effects were the most commonly encountered problem. Nabumetone holds promise as an important new therapeutic approach in arthritis.