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J Virol ; 67(8): 4659-64, 1993 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-8331724

RESUMO

The complete nucleotide sequence of a human T-cell lymphotropic virus type II (HTLV-II) isolate from a Panamanian Guaymi Indian was determined and analyzed. When this new viral isolate (HTLV-IIG12) was compared with prototypic HTLV-IIMoT, the overall nucleotide sequence similarity was 95.4%, while the predicted amino acid sequence similarity was 97.5%. Although the overall percentage of nucleotide and amino acid identity with prototypic HTLV-IIMoT (subtype a) was high, HTLV-IIG12 displayed several distinctive features that defined it as an HTLV-II subtype b. However, there were several characteristics unique to this isolate, which included a cluster of nucleotide substitutions in the pre-gag region and changes in restriction enzyme sites within the pre-gag region and the gag, pol, env, and pX genes. In addition, two nucleotide changes in the C terminus of the Tax protein coding sequence inserted an Arg residue for a stop codon and appeared to result in a larger tax gene product in HTLV-IIG12. Although the HTLV-IIG12 isolate appears to be a variant of the prototypic HTLV-IIb, this information represents the first complete nucleotide sequence of any HTLV-II subtype b. These data will allow further studies on the evolutionary relationships between the HTLV-II subtypes and between HTLV-I and HTLV-II.


Assuntos
Genes Virais , Variação Genética , Vírus Linfotrópico T Tipo 2 Humano/genética , Indígenas Centro-Americanos , Sequência de Aminoácidos , Sequência de Bases , Produtos do Gene tax/genética , Genes gag , Vírus Linfotrópico T Tipo 2 Humano/isolamento & purificação , Humanos , Dados de Sequência Molecular , Panamá , Homologia de Sequência de Aminoácidos , Homologia de Sequência do Ácido Nucleico , TATA Box
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