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1.
J Colloid Interface Sci ; 348(2): 322-8, 2010 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-20510420

RESUMO

In this paper, a new, fast, reproducible technique for atomic force microscopy (AFM) tips functionalization used for chemical interaction measurements is described. Precisely, the deposition of an aminated precursor is performed through plasma-enhanced chemical vapor deposition (PECVD) in order to create amine functional groups on the AFM tip and cantilever. The advantages of the precursor, aminopropyltriethoxysilane (APTES), were recently demonstrated for amine layer formation through PECVD deposition on polymeric surfaces. We extended this procedure to functionalize AFM probes. Titration force spectroscopy highlights the successful functionalization of AFM tips as well as their stability and use under different environmental conditions.


Assuntos
Microscopia de Força Atômica/instrumentação , Microscopia de Força Atômica/métodos , Propilaminas/química , Silanos/química
2.
Biosens Bioelectron ; 25(8): 1875-80, 2010 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-20117925

RESUMO

Here we have demonstrated a solventless plasma-based process that integrates low-cost, high throughput, high reproducibility and ecofriendly process for the functionalization of the next-generation point-of-care device platforms. Amine functionalities were deposited by plasma-enhanced chemical vapour deposition (PECVD) using a new precursor. The influence of the plasma RF power and the deposition time on surfacial properties, as well as their effect on the reactivity and content of amino groups was investigated. The key process determinants were to have a sufficient power in the plasma to activate and partially fragment the monomer but not too much as to lose the reactive amine functionality, and sufficient deposition time to develop a reactive layer but not to consume or erode the amine reactivity. An immunoassay performed using human immunoglobulin (IgG) as a model analyte showed an improvement of the detection limit by two orders of magnitude beyond that obtained using devices activated by liquid-phase reaction.


Assuntos
Aminas/química , Técnicas Biossensoriais/instrumentação , Imunoensaio/instrumentação , Imunoglobulina G/análise , Polienos/química , Desenho de Equipamento , Análise de Falha de Equipamento , Gases/química , Temperatura Alta , Humanos , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Propriedades de Superfície
3.
J Colloid Interface Sci ; 326(2): 333-8, 2008 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-18691720

RESUMO

In this contribution, self-assembled monolayers of n-dodecanethiol (C(12)H(25)SH) at different concentrations on polycrystalline copper have been elaborated. Using XPS, PM-IRRAS, and electrochemical methods (cyclic voltammetry curves and cathodic desorption), the effect of the C(12)H(25)SH concentration on the reduction of the oxide layer has been studied. In all cases, a monolayer of good quality has been obtained. Results provide proof that while the concentration is increased, the thickness of the oxide layer is decreased, to a point that leads to metallic copper for the higher concentration. The results presented in this publication indicate the importance of controlling the interface when forming SAMs of organothiols on oxidizable metals.

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