Cardiac, Respiratory and Postural Influences on Venous Return of Internal Jugular and Vertebral Veins.

It is known from physiology that heartbeat and respiration influence venous return, but little is known regarding the extent to which these two factors affect flow. In this study, we estimated the prevalence of cardiac- and breathing-induced venous flow modulations in the internal jugular vein (IJV) and vertebral vein (VV) and the effects of posture. In 19 healthy patients, neck vein flow was examined with pulsed wave Doppler. Electrocardiogram and respiratory signals were simultaneously acquired. In supine position, heart contraction always influenced venous flow, whereas breathing influenced 68% of IJV and 34% of VV flow. In sitting position, heart contraction influenced 74% of IJV and 42% of VV flow; breathing influenced 68% of IJV and 61% of VV measures. Thus, cardiac influence is greatly present in supine position, whereas breathing influence prevails in the VV while sitting. This setup allowed us to observe that in some patients, expiration may cause an unexpected increase in venous flow.

Virtual navigator 3D panoramic for breast examination.

Breast examination both for screening and second level of investigation has spread worldwide, due to increased breast cancer awareness. Thus, different diagnostic imaging technologies emerged in breast application. Ultrasound (US), a real-time examination, non-invasive, cost effective, ideal also for repetitive follow-up and able to give information about anatomy, hemodynamics and tissue stiffness, plays an important role in breast diagnostics. The present work describes the innovative three-dimensional (3D) Panoramic (Pan) tool of Virtual Navigator technology for real-time fusion imaging of breast 3D US volumes with bi-dimensional US scans. A Motion Control Sensor enables the correction of the examined subject's movements. Data about fusion precision and system performances will be presented regarding tests in vitro, in ex-vivo and in vivo.

Virtual navigator real-time ultrasound fusion imaging with positron emission tomography for liver interventions.

Real-time fusion imaging technologies are increasingly being used among interventional radiologists, mostly Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) dataset, fused with Ultrasound (US) imaging. In addition, fusion of Positron Emission Tomography (PET) and CT is increasingly diffused in clinical practice, due to the wide availability of PET scanners and the capability to make either a direct (acquisitions performed within the same system) or an indirect (procedure performed on an external workstation, merging the two different sets of acquired data) fusion with CT data. The present work describes the feasibility of real-time fusion imaging directly between PET data and US imaging, with CT scans being used only for PET-US fusion registration. Data on multimodality registration precision and clinical applications are presented as well.

Assessment of the cerebral venous system from the transcondylar ultrasound window using virtual navigator technology and MRI.

The Chronic Cerebro-Spinal Venous Insufficiency, recently described as a possible role in Multiple Sclerosis pathogenesis, is diagnosed and classified with Echo Color Doppler (ECD) examination of the extra- and intra-cranial veins. As to the intracranial examination, the presence of reflux in the deep cerebral veins (DCVs) or in the dural sinuses is inspected, with a new insonation approach, i.e. the transcondylar window. This work describes a procedure for the co-registration of anatomical Proton Density-weighted Magnetic Resonance Images (MRI) with the intracranial ECD obtained through the transcondylar window. The procedure, preliminarily tested on 10 volunteers, allowed to assess what are the DCVs visible from this new insonation approach and their position relative to the surrounding brain tissues.