RESUMO
We report literature data indicating that the polyoxyethylene chain of polyoxyethylene detergents attracts cations via dipole-ion interactions thereby attaining a positive charge character. This implies that nonionic polyoxyethylene detergents like Triton X-100 and C12E8 may interact electrostatically with phospholipid head groups. We describe how a positive charge character of Triton X-100 and C12E8 can explain their hitherto mysterious stomatocytogenic shape altering effect in human erythrocytes.
Assuntos
Detergentes/química , Detergentes/metabolismo , Eritrócitos/metabolismo , Polietilenoglicóis/química , Polietilenoglicóis/metabolismo , Cátions/química , Cátions/metabolismo , Membrana Celular/metabolismo , Tamanho Celular , Eritrócitos/citologia , Humanos , Octoxinol/química , Octoxinol/metabolismo , Fosfolipídeos/metabolismo , Eletricidade Estática , Tensoativos/química , Tensoativos/metabolismoRESUMO
It was observed recently that nonionic surfactant octaethyleneglycol dodecylether (Cl2E8) decreases threshold for irreversible electroporation in membrane bilayers. In accordance, it is shown theoretically in this work that anisotropic C12E8 membrane inclusions may stabilize circular hole in a flat membrane segment.
