RESUMO
O objetivo deste relato de caso foi apresentar uma paciente com dermatite atópica (DA) e que no primeiro ano de vida desenvolveu quadro infeccioso grave com eczema difuso em face pescoço e tórax, acompanhado de celulite periorbitária bilateral, febre alta, gemência, hipoatividade e acentuado comprometimento do estado geral. Pele xerótica com lesões vesículares, umbilicadas e com secreção purulenta. O isolamento de Staphy/occus aureus em hemocultura confirmou a suspeita de septicemia e o tratamento antimicrobiano efetivo (Ceftriaxona e Oxacilina) permitiu o seu controle e evidenciou a presença de Eczema herpeticum em face. O tratamento com Aciclovir intra-venoso e cuidados locais possibilitaram o seu controle. A infecção viral funcionou como porta de entrada para o S.aureus causando a septicemia, pouco comum em DA não complicada.
The aim of this report is to relate a one year-old female patient with atopic dermatitis (AD) that developed a severe infectious clinical picture associated with diffuse eczema in face, neck and thorax, bilateral per orbital cellulite, elevated fever, groaning, underactivity, and accentuated commitment of general condition. Pustule umbilicated vesicles over a xerotic skin were observed. Hemoculture reveals Growing of Staphy/occus aureus in hemoculture confirmed septicemia diagnose and specific antibiotic therapy (Ceftriaxona e Oxacilina) allowed its control and put in evidencethe presence of facial Herpeticum eczema. The intravenous treatment with Acyclovir associated with local care enable its control. Virus infection was the S. aureus entrance door causing septicemia, uncommon in no complicated DA patients.
Assuntos
Humanos , Feminino , Lactente , Criança , Dermatite Atópica , Erupção Variceliforme de Kaposi , Sepse , Infecções Estafilocócicas , Staphylococcus aureus/isolamento & purificação , Métodos , Prevalência , Técnicas e Procedimentos DiagnósticosRESUMO
The effect of extracellular Na(+) deprivation on the carbachol-evoked catecholamine secretion was evaluated in chromaffin cells. Isolated adrenal medullae of male Wistar rats were incubated in solutions with different sodium concentrations (144,0; 75,0; 25,0 and psi mM). Catecholamine secretions inversely increased as a response to fall of extracellular concentration of sodium. The magnitude of response to cholinergic stimulus (carbachol 100 microM) was decreased in low extracellular sodium concentration. Atropine (100 microM) inhibited secretion of catecholamine induced by carbachol in the presence and in the absence of extracellular sodium. Results suggest that in isolated adrenal medullae of rats (1) decrease in concentration of extracellular sodium increases secretion of catecholamines, perhaps by a greater influx of calcium from the extracellular environment through reversal of Na(+) /Ca(2+) exchanger; (2) intensity of catecholamine secretion induced by cholinergic stimulus seems to depend on extracellular sodium.