Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 78
Filtrar
1.
Int J Biometeorol ; 2024 May 14.
Artigo em Inglês | MEDLINE | ID: mdl-38740646

RESUMO

Crop growth simulation models relate the soil-water-plant-atmosphere components to estimate the development and yield of plants in different scenarios, enabling the identification of efficient irrigation strategies. The aim of this study was to calibrate crop coefficients for a common bean cultivar (IAPAR 57) and assess the AquaCrop model's efficacy in simulating crop growth under different irrigation regimes (T0 - non-irrigated, T1-fully irrigated, and T2-deficit irrigated) and sowing dates (S1-March 21, S2-April 24, and S3-August 23). Successful calibration was achieved for crop seasons with suitable temperatures to crop growth (S1 and S3). However, during periods with suboptimal temperatures (April 24 season), coupled with reduced irrigation supply (T0 and T2), the AquaCrop model did not appropriately account for the combined effects of thermal and water stresses. Despite adjustments to stress coefficients, this led to an overestimation of crop growth and yield. In long-term simulations, the model successfully replicated the variability of crop water availability over cropping seasons, reflecting the impact of precipitation variations. It recommended irrigation strategies for the study region (irrigate at depletion of 120 and 170% of readily available water for sowing on March 21 and August 24, respectively) to achieve high crop yield (> 2,769 kg ha-1) and water productivity (1,050 to 1,445 kg m-3) with minimal application depths (< 150 mm). While acknowledging the need for improvements in thermal stress calculations, the AquaCrop model demonstrates promising utility in studies and applications where water availability significantly influences crop production.

2.
An Acad Bras Cienc ; 96(1): e20200031, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38359287

RESUMO

The potential of H. virginiana L. was evaluated against Candida spp. (C. albicans, C. dubliniensis, C. glabrata, C. guilliermondii, C. krusei, and C. tropicalis) and bacteria (Acinetobacter baumannii, Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae, Staphylococcus aureus, and Streptococcus mutans). Effect on murine macrophages (RAW 264.7) was also evaluated with respect to cytotoxicity and production of cytokines (IL-1ß and TNF-α) and nitric oxide (NO). The most effective concentrations of the extract were determined by microdilution broth. These concentrations were analyzed on biofilms, after 5 min or 24 h exposure. Cytotoxicity was performed by MTT assay and quantification of cytokines and NO by ELISA and Griess reagent, respectively. The extract acted against the planktonic forms and provided significant reductions of all the microbial biofilms; besides, showed no cytotoxic effect, except at 100 mg/mL, after 24 h exposure. There was cytokine production; however, a modulatory effect was observed in groups exposed to lipopolysaccharide (LPS) from E. coli. NO production was similar or higher than the control group. Thus, H. virginiana L. extract showed antimicrobial and antibiofilm effects; absence of cytotoxicity for RAW 264.7; anti-inflammatory action; and potential to fight infections through the NO production.


Assuntos
Anti-Infecciosos , Candida , Óxido Nítrico , Animais , Camundongos , Hamamelis , Candida albicans , Escherichia coli , Extratos Vegetais/farmacologia , Anti-Infecciosos/farmacologia , Macrófagos , Anti-Inflamatórios/farmacologia , Citocinas , Biofilmes
3.
Rev. andal. med. deporte ; 16(3-4)dic.-2023. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-ADZ-351

RESUMO

Objetivo: Las restricciones de salud pública por el COVID-19 han jugado un papel central en la gestión de los programas de entrenamiento, en los que son escasos los estudios enfocados en la cuantificación de las cargas de entrenamiento en pretemporada, especialmente en futbolistas jóvenes. Por lo tanto, este estudio monitoreó la carga de entrenamiento interno (CEI) durante la pretemporada 2020/2021 durante la pandemia de COVID-19 de los jugadores de fútbol Sub-20. Método: Catorce futbolistas Sub-20 fueron monitoreados durante 7 semanas durante la pretemporada 2020/2021. El CEI de todas las sesiones de entrenamiento se estimó, en unidades arbitrarias, multiplicando el índice de esfuerzo percibido (IEP) para la sesión de entrenamiento completa por la duración de cada sesión de entrenamiento en minutos (IEP-sesión). También se estimaron la monotonía y la tensión de entrenamiento. Un ANOVA unidireccional de medidas repetidas comparó las variables dependientes a lo largo del tiempo. Resultados: En la cuarta semana, la CEI y la tensión de entrenamiento fueron estadísticamente más bajas en comparación con las otras semanas (P<0,05). El índice de monotonía de la semana 7 fue mayor en comparación con las semanas 1, 3 y 4 (P<0,05). Conclusión: Las restricciones sanitarias por el COVID-19 han afectado negativamente la carga de entrenamiento de pretemporada de los futbolistas Sub-20. Sin embargo, el índice de monotonía mostró que las cargas de entrenamiento estaban bien distribuidas durante las 7 semanas. (AU)


Assuntos
Humanos , Atletas , Vigilância em Desastres , Futebol , Desempenho Atlético , Saúde Pública
4.
Obesity (Silver Spring) ; 31(11): 2689-2698, 2023 11.
Artigo em Inglês | MEDLINE | ID: mdl-37840435

RESUMO

OBJECTIVE: This study tested the hypothesis that expression of insulin-like growth factor 1 (IGF-1) protein and mRNA splice variants is lower in skeletal muscle of humans with obesity who have a lower mixed-muscle protein fractional synthesis rate (MMP-FSR) when compared with individuals without obesity. METHODS: The study included nine participants with obesity (OB, mean [SD],  BMI = 35 [3] kg/m2 , MMP-FSR = 0.06%/h [0.02%/h]) and nine participants without obesity (W-OB, BMI = 24 [3] kg/m2 , MMP-FSR = 0.08%/h [0.02%/h]; for both BMI and MMP-FSR p < 0.05). MMP-FSR and mitochondrial protein FSR were measured following an overnight fast. RESULTS: Along with lower MMP-FSR, OB participants displayed lower mitochondrial protein FSR (p = 0.03) compared with W-OB participants. Expression of IGF-1 (p = 0.04) and IGF-1 receptor (p < 0.01) proteins was lower in muscle of OB participants. In addition, OB participants had lower (p < 0.05) mRNA expression of IGF1 variants Eb and Ec. This study demonstrates that lower protein synthesis in muscle of humans with obesity occurs concurrently with lower expression of muscle IGF-1 and IGF-1 receptor proteins, as well as lower mRNA expression of the IGF1 splice variants. CONCLUSIONS: These findings indicate that lower protein synthesis observed in muscle of humans with obesity may result from diminished muscle IGF1 gene expression.


Assuntos
Fator de Crescimento Insulin-Like I , Proteínas Musculares , Humanos , Fator de Crescimento Insulin-Like I/genética , Fator de Crescimento Insulin-Like I/metabolismo , Receptor IGF Tipo 1/genética , Receptor IGF Tipo 1/metabolismo , Músculo Esquelético/metabolismo , Obesidade/genética , Obesidade/metabolismo , RNA Mensageiro/genética , RNA Mensageiro/metabolismo , Proteínas Mitocondriais/metabolismo
5.
Knee Surg Sports Traumatol Arthrosc ; 31(7): 2556-2562, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-36779987

RESUMO

PURPOSE: To evaluate the incidence of anterior cruciate ligament (ACL) injuries in male athletes from professional soccer clubs over two consecutive seasons (2018-2019) with a sub-analysis based on age category: under-13 (U-13), under-15 (U-15), under-17 (U-17), and under-20 (U-20) years. METHODS: A total of 17,108 young male soccer players were retrospectively reviewed from sixty-three professional clubs in the four highest Brazilian soccer divisions. Data regarding the number of athletes and the number of ACL injuries confirmed by magnetic resonance imaging (MRI) exams in the 2018 and 2019 seasons were collected. Incidence of ACL injury were compared by season, age category (under-13; under-15; under 17; and under-20), demographic region, and club division. RESULTS: Clubs from all regions of Brazil participated in the study. A total of 336 primary ACL injuries were diagnosed over the two seasons (8,167 athletes during the 2018 season and 8,941 athletes during the 2019 season) among all athletes, which corresponds to 2% of the included athletes. There were 11 cases (0.3%) in the under-13, 53 cases (1.3%) in the under-15, 107 cases (2.5%) in the under-17, and 165 cases (3.8%) in the under-20 age category. There was a higher incidence of ACL injury in the older age groups (p < 0.001). CONCLUSION: A total of 336 ACL injuries were identified in 17,108 youth soccer players from 63 professional clubs with an overall incidence of 2% over 2 seasons of competition. ACL injury rate ranged from 0.3% to 3.8% and was higher in the older and more competitive club divisions. LEVEL OF EVIDENCE: IV.


Assuntos
Lesões do Ligamento Cruzado Anterior , Traumatismos em Atletas , Futebol , Humanos , Masculino , Adolescente , Idoso , Lesões do Ligamento Cruzado Anterior/epidemiologia , Estações do Ano , Estudos Retrospectivos , Futebol/lesões , Incidência , Atletas , Traumatismos em Atletas/epidemiologia
6.
Front Physiol ; 13: 843087, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35350688

RESUMO

Studies investigating the proteome of skeletal muscle present clear evidence that protein metabolism is altered in muscle of humans with obesity. Moreover, muscle quality (i.e., strength per unit of muscle mass) appears lower in humans with obesity. However, relevant evidence to date describing the protein turnover, a process that determines content and quality of protein, in muscle of humans with obesity is quite inconsistent. This is due, at least in part, to heterogeneity in protein turnover in skeletal muscle of humans with obesity. Although not always evident at the mixed-muscle protein level, the rate of synthesis is generally lower in myofibrillar and mitochondrial proteins in muscle of humans with obesity. Moreover, alterations in the synthesis of protein in muscle of humans with obesity are manifested more readily under conditions that stimulate protein synthesis in muscle, including the fed state, increased plasma amino acid availability to muscle, and exercise. Current evidence supports various biological mechanisms explaining impairments in protein synthesis in muscle of humans with obesity, but this evidence is rather limited and needs to be reproduced under more defined experimental conditions. Expanding our current knowledge with direct measurements of protein breakdown in muscle, and more importantly of protein turnover on a protein by protein basis, will enhance our understanding of how obesity modifies the proteome (content and quality) in muscle of humans with obesity.

7.
Clin Physiol Funct Imaging ; 42(4): 241-249, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35357762

RESUMO

We compared the effects of aerobic exercise with and without blood flow restriction (BFR) to high-intensity aerobic exercise on energy expenditure (EE), excess Postexercise oxygen consumption (EPOC), and respiratory exchange ratio (RER) during and after exercise. Twenty-two recreationally active males randomly completed the following experimental conditions: AE-aerobic exercise without BFR, AE + BFR-aerobic exercise with BFR, HIAE-high-intensity aerobic exercise, CON-non-exercise control condition. EE was significantly (p < 0.05) greater during exercise for HIAE compared to all conditions, and for AE + BFR compared to AE and CON during and postexercise exercise. There were no significant (p > 0.05) differences in EPOC between HIAE and AE + BFR at any time point, however, both conditions were significantly (p < 0.05) greater than the AE (d = 1.50 and d = 1.03, respectively) and CON at the first 10 min postexercise. RER during exercise for HIAE was significantly (p < 0.05) greater than AE + BFR at the first 6 min of exercise (p = 0.003, d = 0.88), however, no significant differences were observed from 9 min up to the end of the exercise. HIAE was also significantly (p < 0.05) greater than AE and CON at all time points during exercise, whereas, AE + BFR was significantly (p < 0.05) greater than CON at all time points but not significantly (p < 0.05) different than AE (p < 0.05); although the overall session RER was significantly (p < 0.05) greater during AE + BFR than AE. Altogether, continuous AE + BFR results in greater EE compared to volume matched AE, as well as a similar EPOC compared to HIAE.


Assuntos
Exercício Físico , Consumo de Oxigênio , Metabolismo Energético , Exercício Físico/fisiologia , Hemodinâmica , Humanos , Masculino , Fluxo Sanguíneo Regional/fisiologia
8.
Cureus ; 14(3): e23243, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35342667

RESUMO

The infection with SARS-CoV-2 is primarily associated with respiratory symptoms. Since its appearance, several neurological symptoms have been reported, most commonly headache and anosmia, as well as less frequent complications such as COVID-19-associated encephalitis and meningitis. In this case report, we describe two patients, who were 49- and 50-year-old infected with SARS-CoV-2, who presented to the emergency department with altered mental status and behavioral changes. A diagnosis of acute meningoencephalitis associated with COVID-19 was considered, and both patients had a good response to corticosteroid treatment.

9.
Cytokine ; 151: 155787, 2022 03.
Artigo em Inglês | MEDLINE | ID: mdl-35065509

RESUMO

This cross-sectional study examined the associations between serum interleukin-6 (IL-6) and muscle, bone, and fat parameters in recreationally active women. One-hundred forty-five women (48.7 ± 17.8 years; 164.4 ± 7.1 cm; 66.8 ± 10.7 kg; and 24.7 ± 3.9 kg/m2) underwent dual energy x-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) assessments to determine total and regional muscle, bone, and fat parameters. Muscle performance of the knee extensors was examined via isometric, isotonic, and isokinetic dynamometry assessments, and serum IL-6 was measured via enzyme linked immunosorbent assay. Serum IL-6 was inversely associated with thigh muscle cross-sectional area (mCSA, r = -0.28, p < 0.01); isometric strength (r = -0.19, p < 0.05); hip areal bone mineral density [aBMD] (r = -0.18, p < 0.05); trochanter aBMD (r = -0.23, p < 0.01); total body aBMD (r = -0.20, p < 0.05); cortical volumetric bone density at 38 and 66% tibia (r = -0.18 and r = -0.19, respectively, both p < 0.05), and 66% cortical thickness (r = -0.17, p < 0.05). These associations were present after adjusting for age, BMI, and physical activity. Thigh mCSA was significantly lower in the tertile possessing the greatest IL-6 compared to the lowest tertile (p < 0.01); after adjusting for age, body mass index, and physical activity. Collectively, these observations indicate that IL-6 is inversely associated with skeletal muscle and bone parameters independent of relevant confounders. These observations bolster the prognostic value of serum IL-6.


Assuntos
Densidade Óssea , Interleucina-6 , Absorciometria de Fóton , Tecido Adiposo , Densidade Óssea/fisiologia , Estudos Transversais , Feminino , Humanos , Músculo Esquelético
10.
J Therm Biol ; 103: 103151, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-35027201

RESUMO

As global temperatures continue to rise due to global change, marine heatwaves are also becoming more frequent and intense, impacting marine biodiversity patterns worldwide. Organisms inhabiting shallow water environments, such as the commercially relevant ditch shrimp Palaemon varians, are expected to be the most affected by rising temperatures. Thus, addressing species' thermal ecology and climate extinction-risk is crucial to foster climate-smart conservation strategies for shallow water ecosystems. Here, we estimated sex-specific upper thermal tolerance limits for P. varians via the Critical Thermal Maximum method (CTmax), using loss of equilibrium as endpoint. We further calculated thermal safety margins for males and females and tested for correlations between upper thermal limits and shrimps' body size. To determine sex-biased variation in P. varians' traits (CTmax, weight and length), we compared trait variation between females and males through the coefficient of variation ratio (lnCVR). Females displayed an average CTmax value 1.8% lower than males (CTmaxfemales = 37.0 °C vs CTmaxmales = 37.7 °C). This finding may be related to the larger body size exhibited by females (156% heavier and 39% larger than males), as both length and weight had a significant effect on CTmax. The high energetic investment of females in offspring may also contribute to the differences recorded in thermal tolerance. Overall, organisms with a smaller body-size displayed a greater tolerance to elevated temperature, thus suggesting that smaller individuals may be positively selected in warmer environments. This selection may result in a reduction of size-at-maturity and shifts in sex ratio, given the sexual dimorphism in body size of shrimps. The thermal safety margin of P. varians was narrow (∼2.2 °C for males and ∼1.5 °C for females), revealing the vulnerability of this species to ocean warming and heatwaves.


Assuntos
Biodiversidade , Evolução Biológica , Tamanho Corporal , Palaemonidae/fisiologia , Termotolerância , Aclimatação , Animais , Mudança Climática , Feminino , Masculino , Oceanos e Mares , Temperatura
11.
Front Physiol ; 12: 747759, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34925056

RESUMO

The use of blood flow restricted (BFR) exercise has become an accepted alternative approach to improve skeletal muscle mass and function and improve cardiovascular function in individuals that are not able to or do not wish to use traditional exercise protocols that rely on heavy loads and high training volumes. BFR exercise involves the reduction of blood flow to working skeletal muscle by applying a flexible cuff to the most proximal portions of a person's arms or legs that results in decreased arterial flow to the exercising muscle and occluded venous return back to the central circulation. Safety concerns, especially related to the cardiovascular system, have not been consistently reported with a few exceptions; however, most researchers agree that BFR exercise can be a relatively safe technique for most people that are free from serious cardiovascular disease, as well as those with coronary artery disease, and also for people suffering from chronic conditions, such as multiple sclerosis, Parkinson's, and osteoarthritis. Potential mechanisms to explain the benefits of BFR exercise are still mostly speculative and may require more invasive studies or the use of animal models to fully explore mechanisms of adaptation. The setting of absolute resistive pressures has evolved, from being based on an individual's systolic blood pressure to a relative measure that is based on various percentages of the pressures needed to totally occlude blood flow in the exercising limb. However, since several other issues remain unresolved, such as the actual external loads used in combination with BFR, the type of cuff used to induce the blood flow restriction, and whether the restriction is continuous or intermittent, this paper will attempt to address these additional concerns.

12.
IDCases ; 26: e01286, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34603962

RESUMO

Whipple's disease is a rare disease, which can be fatal if not treated. It is often diagnosed at a late stage because of the varied disease presentation and its rare incidence. Classic Whipple's disease presents with arthralgia, abdominal pain, diarrhea and weight loss. CT abdomen may show mesenteric lymphadenopathy with hypodense centers. These CT findings along with clinical presentation should prompt early diagnosis of Whipple's disease. We present a case of classic Whipple's disease with interesting CT abdomen and PET scan findings.

13.
Mult Scler Relat Disord ; 55: 103154, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34348212

RESUMO

BACKGROUND: Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system. Prodromal symptoms and higher healthcare use have been suggested in patients who later develop MS. OBJECTIVES: Assess the healthcare utilization pattern of relapsing-remitting MS (RRMS) patients in the five years prior to MS diagnosis. METHODS: Retrospective, multicentric study. Demographic and clinical data, drug prescriptions and diagnostic tests were collected from electronic health records five-years previous to MS diagnosis and compared with national data. RESULTS: Included 168 patients, 112 (66.7%) female, median age 34±11 years. The mean number of healthcare use per patient per year was 3.14±2,69, most of them in primary healthcare (47%). Most frequent symptoms were musculoskeletal (22%), gastrointestinal (17%), sensitive (14%) and sensory organs (14%). Median number of diagnostic tests per patient was 6 (IQR 7), and drug prescriptions per patient was 6 (IQR 9). Most frequently prescribed drugs were analgesic/anti-inflammatories, antibiotics and anxiolytics and there was a high request rate of MRIs. CONCLUSION: RRMS patients had a high frequency of healthcare utilization when compared to national data. This supports the current evidence showing a prodromal phase in MS.


Assuntos
Esclerose Múltipla Recidivante-Remitente , Esclerose Múltipla , Adulto , Feminino , Acessibilidade aos Serviços de Saúde , Humanos , Pessoa de Meia-Idade , Esclerose Múltipla/diagnóstico , Esclerose Múltipla/tratamento farmacológico , Esclerose Múltipla/epidemiologia , Portugal/epidemiologia , Estudos Retrospectivos , Adulto Jovem
14.
Artigo em Inglês | MEDLINE | ID: mdl-33922474

RESUMO

The purpose of this study was to examine age-related differences in muscle performance in women divided into young (YW, 20-39 years, n = 29) middle-aged (MAW, 40-59 years, n = 33), and older (OW, ≥60 years, n = 40) age groups. METHODS: Hand grip strength, vertical jump performance, and knee extensor (KE) strength (0 deg/s, 60 deg/s, and 240 deg/s), speed of movement (SoM; at 1 Nm, 20%, 40%, and 60% isometric strength), and endurance (30-repetition test at 60 degs/s and 240 deg/s) were assessed. Computed tomography-acquired muscle cross-sectional area (mCSA) was measured and included to determine specific strength (KE strength/mCSA). RESULTS: Hand grip strength was similar across groups, while jump performance declined with age (YW and MAW > OW, p < 0.001). KE strength declined significantly with age (all conditions p < 0.01), while specific strength was similar across groups. SoM was significantly higher for YW and MAW compared to OW (both p < 0.01). An age × velocity interaction revealed YW KE endurance was similar between conditions, whereas MAW and OW displayed significantly better endurance during the 60 deg/s condition. OW displayed impaired KE endurance at 240 deg/s (vs. YW and MAW, p < 0.01) but improved at 60 deg/s (vs. YW, p < 0.01). Dynamic torque decline increased with age (YW < OW, p = 0.03) and was associated with intramuscular adipose tissue (r = 0.21, p = 0.04). CONCLUSIONS: Performance declines were most evident among OW, but few performance deficits had emerged in MAW. Interestingly, strength declines disappeared after normalizing to mCSA and endurance appears to be velocity-dependent.


Assuntos
Envelhecimento , Força da Mão , Adulto , Feminino , Humanos , Joelho , Pessoa de Meia-Idade , Força Muscular , Músculo Esquelético , Adulto Jovem
15.
Arthroscopy ; 37(8): 2582-2588, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-33771692

RESUMO

PURPOSE: To evaluate the relation between the femoral intercondylar index, tibial slope, and meniscal slope between 3 different groups of skeletally immature patients: primary anterior cruciate ligament (ACL) injury (group 1), ACL reconstruction failure (group 2), and control group, without an ACL injury history (group 3). METHODS: This retrospective study evaluated magnetic resonance imaging scans of the knees of 605 skeletally immature patients obtained between 2015 and 2020. The inclusion criteria were as follows: patients younger than 16 years who were skeletally immature and underwent knee magnetic resonance imaging for any reason. RESULTS: A total of 605 skeletally immature patients were included in the study. The ratio of patients with ACL injury (cases) to those without ACL injury (controls) was 1:2.5. Patients with ACL injury had significantly greater medial meniscal slope and lateral meniscal slope values than the control group without ACL injury (P < .001). There was no statistically significant difference between patients with primary ACL injury and those with ACL reconstruction failure for all measured variables. CONCLUSIONS: The medial and lateral meniscal slope values were significantly higher in skeletally immature patients with ACL injury than in the control group of patients without ACL injury. There was no statistically significant difference in measurements of the femoral intercondylar index, lateral meniscal slope, medial meniscal slope, lateral tibial slope, or medial tibial slope between patients with primary injury and those with ACL reconstruction failure. LEVEL OF EVIDENCE: Level III, retrospective comparative trial.


Assuntos
Lesões do Ligamento Cruzado Anterior , Reconstrução do Ligamento Cruzado Anterior , Lesões do Ligamento Cruzado Anterior/diagnóstico por imagem , Lesões do Ligamento Cruzado Anterior/cirurgia , Humanos , Meniscos Tibiais/cirurgia , Estudos Retrospectivos , Fatores de Risco
16.
Cureus ; 13(2): e13601, 2021 Feb 28.
Artigo em Inglês | MEDLINE | ID: mdl-33654647

RESUMO

Ataxia with oculomotor apraxia is a rare neurodegenerative subgroup of diseases with manifestations that include cerebellar ataxia, oculomotor apraxia, extrapyramidal features, and sensorimotor neuropathy. In 2015, ataxia with oculomotor apraxia type 4 was described in 11 Portuguese individuals. The mean age of onset was 4.3 years, with severe extrapyramidal manifestations, neuropathy, rapid progression, and ataxia, being wheelchair-bound during adolescence. The disease is caused by homozygous or compound heterozygous mutations in the PNKP gene. In this case report, we describe two sisters, who were 52- and 58-years-old, with cerebellar dysarthria, oculomotor apraxia, dystonia, and gait ataxia. Two new mutations in the PNKP gene were detected in both sisters, confirming the diagnosis of ataxia with oculomotor apraxia. They were remarkable because they were able to walk unaided during adulthood and had epilepsy. With these clinical cases, we attempt to raise awareness of the possibility of different phenotypes of this rare disease, expanding the spectrum of manifestations of ataxia with oculomotor apraxia type 4.

17.
Physiol Meas ; 42(3)2021 04 09.
Artigo em Inglês | MEDLINE | ID: mdl-33631736

RESUMO

Objective. The measurement of skin temperature using infrared thermography has gained a lot of attention in sport and science since it might be related to the recovery process following high intensity, potentially damaging exercise. This study investigated the time course of the skin temperature response and the muscle recovery status following a resistance training session involving leg press exercise.Approach. Fourteen young male college students (19.9 ± 1.7 years, 176 ± 6 cm, 66.1 ± 7.6 kg, 21.1 ± 1.8 kg.m-2) performed one session involving 10 sets, of 10 repetition maximum each (RM), of unilateral leg press 45° exercise, performed to momentary muscle failure, with 2 min rest between sets. Perceived recovery, mean and maximum thigh skin temperatures, thigh muscle thickness, maximal isometric strength, muscle soreness, and horizontal jump performance were measured pre, 24, 48, and 72 h following exercise.Main results. The exercise protocol resulted in significant reduction in isometric strength, horizontal jump performance, and perceived recovery (p < 0.05). There was also a significant (p < 0.05) increase in muscle thickness and muscle soreness. With exception of jump performance, that recovered at 48 (p > 0.05), recovery parameters did not recover up to 72 h post-exercise (p > 0.05). Surprisingly, skin temperatures were not altered throughout the entire 72 h post-exercise period (p > 0.05). No significant positive correlation was found between skin temperatures and muscle thickness. Additionally, only one out of 16 correlation coefficients showed significant (r = -0.56,p = 0.036) inverse association between skin temperature and isometric strength.Significance. In conclusion, thigh skin temperature remains unaffected up to 72 h following a leg press exercise, and the time course response of thigh skin temperature was not associated with recovery status.


Assuntos
Treinamento Resistido , Temperatura Cutânea , Humanos , Perna (Membro) , Masculino , Força Muscular , Músculo Esquelético
18.
Nanomaterials (Basel) ; 11(1)2021 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-33430503

RESUMO

This study addresses the combination of customized surface modification with the use of nanofluids, to infer on its potential to enhance pool-boiling heat transfer. Hydrophilic surfaces patterned with superhydrophobic regions were developed and used as surface interfaces with different nanofluids (water with gold, silver, aluminum and alumina nanoparticles), in order to evaluate the effect of the nature and concentration of the nanoparticles in bubble dynamics and consequently in heat transfer processes. The main qualitative and quantitative analysis was based on extensive post-processing of synchronized high-speed and thermographic images. To study the nucleation of a single bubble in pool boiling condition, a numerical model was also implemented. The results show an evident benefit of using biphilic patterns with well-established distances between the superhydrophobic regions. This can be observed in the resulting plot of the dissipated heat flux for a biphilic pattern with seven superhydrophobic spots, δ = 1/d and an imposed heat flux of 2132 w/m2. In this case, the dissipated heat flux is almost constant (except in the instant t* ≈ 0.9 when it reaches a peak of 2400 W/m2), whilst when using only a single superhydrophobic spot, where the heat flux dissipation reaches the maximum shortly after the detachment of the bubble, dropping continuously until a new necking phase starts. The biphilic patterns also allow a controlled bubble coalescence, which promotes fluid convection at the hydrophilic spacing between the superhydrophobic regions, which clearly contributes to cool down the surface. This effect is noticeable in the case of employing the Ag 1 wt% nanofluid, with an imposed heat flux of 2132 W/m2, where the coalescence of the drops promotes a surface cooling, identified by a temperature drop of 0.7 °C in the hydrophilic areas. Those areas have an average temperature of 101.8 °C, whilst the average temperature of the superhydrophobic spots at coalescence time is of 102.9 °C. For low concentrations as the ones used in this work, the effect of the nanofluids was observed to play a minor role. This can be observed on the slight discrepancy of the heat dissipation decay that occurred in the necking stage of the bubbles for nanofluids with the same kind of nanoparticles and different concentration. For the Au 0.1 wt% nanofluid, a heat dissipation decay of 350 W/m2 was reported, whilst for the Au 0.5 wt% nanofluid, the same decay was only of 280 W/m2. The results of the numerical model concerning velocity fields indicated a sudden acceleration at the bubble detachment, as can be qualitatively analyzed in the thermographic images obtained in this work. Additionally, the temperature fields of the analyzed region present the same tendency as the experimental results.

19.
J Strength Cond Res ; 35(4): 1089-1094, 2021 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-30272627

RESUMO

ABSTRACT: Heishman, AD, Daub, BD, Miller, RM, Freitas, EDS, and Bemben, MG. Longitudinal hydration assessment in collegiate basketball players over various training phases. J Strength Cond Res 35(4): 1089-1094, 2021-To the best of our knowledge, previous literature has not longitudinally examined hydration status in collegiate basketball players. Therefore, the purpose of this investigation was to examine the prepractice hydration status of collegiate basketball players across various training phases for 2 consecutive years. Retrospective analyses examined prepractice urine-specific gravity (USG) assessments obtained from National Collegiate Athletic Association (NCAA) Division I male basketball players during the preseason and competitive season, for 2 consecutive years. The first year (year 1 = Y1) of analysis consisted of 15 athletes and the second year (year 2 = Y2) consisted of 16 athletes, with 8 athletes in both seasons. Hydration status was classified based on the National Athletic Trainers' criteria: (a) euhydrated, USG < 1.020; (b) hypohydrated, USG = 1.020-1.030; and (c) significantly hypohydrated, USG > 1.030. Additional comparisons examined the association of minutes played with hydration status and changes in hydration status for athletes returning from Y1 to Y2. The results indicated 55-65.7% of cases showed levels of significant hypohydration during the preseason and competitive seasons for both years. Preseason hydration status was significantly better than the competitive season (Y1, p = 0.008; Y2, p = 0.005). Despite significant differences in minutes played (p < 0.001), no differences in hydration status were observed. Returning athletes displayed no differences in hydration status between Y1 and Y2. Collegiate basketball players show levels of hypohydration when longitudinally examined across various training phases. Although hydration may be improved in the preseason, alternative factors such as average game minutes played and length in program may not influence hydration status.


Assuntos
Basquetebol , Atletas , Humanos , Masculino , Estudos Retrospectivos , Universidades , Urinálise
20.
J Strength Cond Res ; 35(11): 3050-3055, 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-31567839

RESUMO

ABSTRACT: Ferreira-Júnior, JB, Benine, RPC, Chaves, SFN, Borba, DA, Martins-Costa, HC, Freitas, EDS, Bemben, MG, Vieira, CA, and Bottaro, M. Effects of static and dynamic stretching performed before resistance training on muscle adaptations in untrained men. J Strength Cond Res 35(11): 3050-3055, 2021-This study evaluated the effects of dynamic and static stretching (SS) performed before resistance training on biceps femoris hypertrophy and knee flexor strength gains in untrained young men. Forty-five untrained young men (age, 21.2 ± 0.5 years; mass, 72.2 ± 5.6 kg; height, 178 ± 1 cm) were randomly assigned to 1 of the 3 groups: (a) 80 seconds of SS (n = 14); (b) 80 seconds of dynamic stretching (DS, n = 13); or (c) control group (CON, n = 18) in which subjects performed no stretching before exercise. Both SS and DS were performed before resistance exercise. Resistance training consisted of 4 sets of 8-12 repetition maximum of seated leg curl exercise 2 days per week for 8 weeks, with a period of at least 48 hours between sessions. Unilateral biceps femoris muscle thickness (MT) and maximal isometric strength (MIS) of the knee flexors were measured 1 week before training and 1 week after the last training session. There were significant increases in MIS (SS = 13.9 ± 10.3 kgf; DS = 10.2 ± 13.1 kgf; CON = 12.7 ± 7.6 kgf; p < 0.05) and MT (SS = 6.0 ± 3.5 mm; DS = 6.7 ± 4.1 mm; CON = 5.7 ± 3.0 mm; p < 0.05) with no significant differences across groups (p > 0.05). Additionally, all groups demonstrated moderate effect sizes for MIS (1.27-1.4), and DS was the only group that had a large effect size for MT increases (DS = 2.18; SS = 1.35; CON = 0.92). In conclusion, 80 seconds of SS and DS did not induce any additional muscular adaptations to resistance training in untrained young men.


Assuntos
Músculos Isquiossurais , Exercícios de Alongamento Muscular , Treinamento Resistido , Adulto , Humanos , Masculino , Força Muscular/fisiologia , Músculo Esquelético/fisiologia , Adulto Jovem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...