Headache as the most prevalent post-vaccination adverse event after Covid-19 vaccination / Dor de cabeça como evento adverso pós-vacinação mais prevalente após a vacinação contra Covid-19

BACKGROUND: In 2020, the first vaccines were approved, according to the WHO. However, speculations arose regarding their efficacy and post-vaccination adverse events (AEFV). OBJECTIVE: To evaluate the prevalence of headache as AEFI from the SARSCoV-2 vaccine in Piauí, Brazil. METHODS: This is a quantitative, observational, cross-sectional, and prevalence study. Data were provided by the Post-Vaccination Adverse Event Information System (SI-AEFV), from reported cases from January to September 2021. Data were analyzed, and the research was approved by the UFPI Research Ethics Committee. RESULTS: A total of 2,008 cases were analyzed. Headache was reported in 752 cases (27.99%) as an AEFV after vaccination against SARS-CoV-2. In most cases, patients were from Teresina (67.62%), of brown race/ethnicity (52.67%), female (79.00%), and the majority were not healthcare professionals (54.27%). The most common age of patients, with the original data, was 33 years. After data correction, the most common age was 28 years. The majority of these cases were not severe (96.44%), and the majority of cases were associated with the first dose of the Covid-19-Covishield-Oxford/AstraZeneca vaccine (43.18%).CONCLUSION: Thus, it is concluded from the partial analysis of the results that headache is the most common adverse event after vaccination against SARS-CoV-2. The profile of patients with the most notifications was brown women aged 30 to 40 years who received the first dose of the Covid-19-Covishield-Oxford/AstraZeneca vaccine. Regarding the severity of events, the vast majority were considered non-severe, and no deaths were mentioned, demonstrating the safety of immunobiologicals.

FUNDAMENTO: Em 2020, foram aprovadas as primeiras vacinas, segundo a OMS. No entanto, surgiram especulações quanto à sua eficácia e eventos adversos pós-vacinais (EAPV). OBJETIVO: Avaliar a prevalência de cefaleia como EAPV da vacina SARSCoV-2 no Piauí, Brasil. MÉTODOS: Trata-se de um estudo quantitativo, observacional, transversal e de prevalência. Os dados foram fornecidos pelo Sistema de Informação de Eventos Adversos Pós-Vacinação (SI-AEFV), dos casos notificados no período de janeiro a setembro de 2021. Os dados foram analisados ​​e a pesquisa foi aprovada pelo Comitê de Ética em Pesquisa da UFPI. RESULTADOS: Foram analisados ​​2.008 casos. Cefaleia foi relatada em 752 casos (27,99%) como EAPV após vacinação contra SARS-CoV-2. Na maioria dos casos, os pacientes eram procedentes de Teresina (67,62%), de raça/etnia parda (52,67%), do sexo feminino (79,00%) e a maioria não era profissional de saúde (54,27%). A idade mais comum dos pacientes, com os dados originais, era de 33 anos. Após correção dos dados, a idade mais comum foi 28 anos. A maioria desses casos não foi grave (96,44%), e a maioria dos casos esteve associada à primeira dose da vacina Covid-19-Covishield-Oxford/AstraZeneca (43,18%).CONCLUSÃO: Assim, conclui-se a partir da análise parcial dos resultados de que cefaleia é o evento adverso mais comum após vacinação contra SARS-CoV-2. O perfil dos pacientes com mais notificações foi de mulheres pardas com idade entre 30 e 40 anos que receberam a primeira dose da vacina Covid-19-Covishield-Oxford/AstraZeneca. Quanto à gravidade dos eventos, a grande maioria foi considerada não grave e não foram mencionados óbitos, demonstrando a segurança dos imunobiológicos.

Narratividade na promoção da saúde: limites e possibilidades da racionalidade médica homeopática no cuidado centrado no sujeito / Narrativity in promoting health: limits and possibilities of homeopathic medical rationality in subject-centered care

Este artigo tem como objeto o papel da narração das histórias de vida dos pacientes durante a consulta homeopática na promoção da saúde e produção de autonomia dos sujeitos. Objetivos e Metodologia: A partir da abordagem sócio-histórica, foi realizada revisão de literatura narrativa, a fim de identificar os limites e as possibilidades do ato de narrar na racionalidade médica homeopática para a produção de subjetividades e autonomia na trajetória singular de cada indivíduo levar sua vida. Considerações Finais: Há atualidade e consonância de conceitos da racionalidade médica homeopática com o paradigma contemporâneo da promoção da saúde; as narrativas produzidas no ato da anamnese homeopática têm a potencialidade de ampliar a compreensão médica e do indivíduo para além da doença, analisando o fenômeno existencial do adoecimento. A anamnese homeopática, ao valorizar as experiências existenciais relatadas no âmbito de uma consulta, concorre para uma valorização dos sujeitos, o que contribuiria para a construção de sua subjetividade, autonomia e emponderamento.

This article focuses on the role of narrating patients' life stories during homeopathic consultations in promoting health and producing autonomy for subjects. Objectives and Methodology: Using a socio-historical approach, a narrative literature review was carried out in order to identify the limits and possibilities of the act of narrating in homeopathic medical rationality for the production of subjectivities and autonomy in the unique trajectory of each individual. your life. Final Considerations: The concepts of homeopathic medical rationality are current and consistent with the contemporary paradigm of health promotion; The narratives produced in the act of homeopathic anamnesis have the potential to expand medical and individual understanding beyond the disease, analyzing the existential phenomenon of illness. Homeopathic anamnesis, by valuing the existential experiences reported in the context of a consultation, contributes to an appreciation of the subjects, which would contribute to the construction of their subjectivity, autonomy and empowerment.

Mortality in a swiftly repurposed hospital in northeast Brazil during the first and second COVID-19 waves: A retrospective cohort study.

Background: The first months of the coronavirus disease 2019 (COVID-19) pandemic demanded rapid re-organization of available local resources. This study evaluated the performance of a private hospital in the Brazilian state of Ceará that was swiftly repurposed into a public tertiary COVID-19 centre during the first wave of the COVID-19 pandemic, and how it improved in the second wave. Methods: This retrospective cohort study included 2492 patients with COVID-19 at Hospital Estadual Leonardo da Vinci (HELV) during the first and second waves. Demographic, clinical and laboratory data were collected using a dedicated web platform (ResCOVID). A Poisson regression model was used to estimate factors associated with in-hospital mortality. Results: Differences in demographics and clinical features were found between the two waves. There was reduced in-hospital mortality during the second wave (36.2%) in comparison with the first wave (48.8%). Invasive mechanical ventilation showed the strongest association with increased risk of death in both waves {first wave: relative risk (RR) 4.28 [95% confidence interval (CI) 2.86-6.41], P<0.001; second wave: RR 12.94 (95% CI 3.4-49.12), P<0.001}. Conclusions: HELV was a pillar in the strategic public health plan to respond to COVID-19 in Ceará, helping to assist a group of moderate-to-severe cases and reduce the pressure on emergency and primary care facilities. Although mortality in intubated individuals remained high, there was an overall decrease in the in-hospital mortality rate in the second wave.

Prevalência de sífilis e fatores de risco associados em internos do sistema prisional do Piauí / Prevalence of syphilis and associated risk factors in prisoners in the Piauí prison system / Prevalencia de sífilis y factores de riesgo asociados en internos del sistema penitenciario de Piauí

Objetivo: Objetivou-se analisar a prevalência de sífilis e fatores de risco em internos nos presídios do Estado do Piauí, Brasil. Métodos: Estudo epidemiológico, transversal, realizado com 2.131 presidiários. Na estatística inferencial foram aplicados testes de hipóteses, com a utilização de regressão logística. O nível de significância utilizado foi de 5%. Resultados: A prevalência de positividade para sífilis foi de 8,4% (IC95% = 7,3-9,6), sendo 19,5% no sexo feminino e 80,5% no sexo masculino. Na análise bivariada observou-se associação entre a sífilis e as variáveis: sexo, uso de drogas ilícitas, uso de piercings, prática sexual com parceiros do mesmo sexo, uso de drogas antes das relações sexuais e conhecimento sobre a forma de transmissão. No modelo multivariado permaneceu associada apenas o uso de drogas antes das relações sexuais. Conclusão: Faz-se necessário promover articulação entre esferas governamentais e entre gestão da saúde e da justiça, para elaborar estratégias de modo a contemplar a demanda de saúde dos internos do sistema prisional do Estado. (AU)

Objective: The objective was to analyze the prevalence of syphilis and risk factors in inmates in prisons in the State of Piauí, Brazil. Methods: Epidemiological, cross-sectional study carried out with 2,131 inmates. In inferential statistics, hypothesis tests were applied, using logistic regression. The level of significance used was 5%. Results: The prevalence of positivity for syphilis was 8.4% (95% CI = 7.3-9.6), 19.5% in females and 80.5% in males. In the bivariate analysis, an association was observed between syphilis and the variables: sex, use of illicit drugs, use of piercings, sexual practice with partners of the same sex, use of drugs before sexual intercourse and knowledge about the form of transmission. In the multivariate model, only drug use remained associated before sexual intercourse. Conclusion: It is necessary to promote articulation between governmental spheres and between health and justice management, in order to develop strategies in order to contemplate the health demand of inmates in the state prison system. (AU)

Objetivo: Este estudio tuvo como objetivo analizar la prevalencia de sífilis y factores de riesgo en reclusos en cárceles del estado de Piauí, Brasil. Métodos: Estudio epidemiológico transversal realizado con 2.131 internos. En estadística inferencial se aplicaron pruebas de hipótesis mediante regresión logística. El nivel de significancia utilizado fue del 5%. Resultados: La prevalencia de positividad para sífilis fue del 8,4% (IC 95% = 7,3-9,6), siendo 19,5% en mujeres y 80,5% en hombres. En el análisis bivariado se observó asociación entre sífilis y las variables: género, uso de drogas ilícitas, uso de piercings, práctica sexual con parejas del mismo sexo, uso de drogas antes de la relación sexual y conocimiento sobre la forma de transmisión. En el modelo multivariado, solo el consumo de drogas antes de las relaciones sexuales permaneció asociado. Conclusion: Es necesario promover la articulación entre los ámbitos gubernamentales y entre la gestión de la salud y la justicia, a fin de desarrollar estrategias para atender la demanda de salud de los internos del sistema penitenciario estatal. (AU)

Matriz de competências para o ensino da homeopatia na graduação médica / Competency matrix for undergraduate medical education in homeopathy

Resumo: Introdução: Currículos médicos de graduação são extremamente carregados em seu conteúdo, tornando-se primordial a necessidade de otimizar competências essenciais. As Diretrizes Curriculares Nacionais (DCN) do Curso de Graduação em Medicina preconizam uma valorização do tratamento do doente que possui muitas interfaces com a homeopatia. Apesar de ser uma especialidade médica no Brasil reconhecida desde 1980, a homeopatia ainda é pouco presente na graduação médica. Objetivo: Este estudo teve como objetivo desenvolver uma matriz de competências essenciais composta de conhecimentos e habilidades desejáveis para o ensino da homeopatia na graduação médica. Métodos: Trata-se de um estudo quanti-qualitativo realizado por meio da técnica Delphi normativa, em duas rodadas, com os docentes especialistas em homeopatia do país. Na primeira rodada, aplicou-se um questionário anônimo on-line para identificar as competências (conhecimentos e habilidades) necessárias em homeopatia para os discentes de graduação em Medicina. Após a análise de conteúdo, os temas foram agrupados nessas duas categorias que retornaram para apuração na segunda rodada, em que os especialistas assinalaram o grau de concordância (escala de Likert de quatro pontos: de não relevante a muito relevante). Para a definição de consenso, adotaram-se dois critérios: índice de De Loe e uma nota de relevância adotada pelos autores com vistas a discriminar mais os graus de consenso. Resultados: Dos 14 temas/subtemas relacionados como competências/conhecimentos, consideraram-se 11 como de alto consenso, dos quais cinco foram avaliados como primordiais, pois obtiveram nota de relevância acima de 9,0 (três relacionados ao grande tema clínica homeopática; um, à teoria e técnica homeopáticas; e outro, à pesquisa homeopática). Em relação às competências/habilidades, oito das 11 foram consideradas de alto consenso, e somente duas alcançaram nota acima de 9,0, ambas relacionadas à clínica homeopática. Conclusão: O ensino da homeopatia pode contribuir para a mudança paradigmática da medicina no sentido de valorizar o doente e promover a saúde, permitindo uma atuação médica mais humanizada e centrada no doente, o que justificaria a adoção de seu ensino, inclusive obrigatório, nas faculdades de Medicina. A elaboração de uma matriz de competências do que deve ser ensinado de homeopatia aos discentes da graduação médica vem ao encontro das DCN e instrumentaliza a reflexão na elaboração de uma futura ementa.

Abstract: Introduction: Undergraduate medical curricula are overloaded with content, making the need to optimize essential skills and knowledge paramount. The National Curricular Guidelines for the medical course (DCNs) put focus on patient treatment, which involves several interfaces with homeopathy. However, despite it being recognized as a medical specialty in Brazil since 1980, homeopathy is rarely present in undergraduate medical education. Objective: To develop a collection of essential skills and knowledge for teaching homeopathy as part of the undergraduate medical curriculum. Methods: Quanti-qualitative study performed using the standard Delphi technique in two rounds with specialized homeopathy teachers from Brazil. An anonymous online questionnaire was conducted to identify the learning competences needed in homeopathy for undergraduate medical students. Following content analysis, the themes and sub-themes were grouped into the two main categories of knowledge and skills, which were returned to the specialists who rated their importance for each item using the "Four-Point Likert Scale" from not at all important to very important. For the purpose of generating a general consensus, two criteria were adopted: the "De Loe index" and a importance score. Results: There was a high degree of consensus regarding eleven of the fourteen themes/sub-themes, five of which were considered essential, with an importance score above 9.0 (three related to the general theme, Homeopathic Clinic, one to Homeopathic Theory and Method and another to Homeopathic Research). There was also a high level of consensus regarding eight of the eleven skills, but only two gained a score of above 9.0, both related to Homeopathic Clinic. Conclusion: The teaching of Homeopathy can contribute to a paradigmatic change in medicine, particularly in the sense of prioritizing the patient and promoting health, as well as allowing for a more humanized and patient-centered medical engagement. These factors would justify the adoption of its teaching, so much so it could be made mandatory across all medical study. The establishment of a "competency matrix" for homeopathy study, which ought to be taught to students of the medical field, meets the DCNs and would be instrumental in future syllabuses.

Prática de saúde na atenção básica na perspectiva da política de humanização num município cearense / Practice in health and primary care from the perspective of humanization policy in the municipality of Ceará

O Sistema Único de Saúde após suas fases iniciais de garantia de acesso, de construção de infraestrutura, de definição de processos de financiamento, introduziu uma dimensão qualitativa que se traduziu pela Política Nacional de Humanização da Atenção e da Gestão em Saúde. A pesquisa objetivou compreender a humanização da saúde na atenção básica no Sistema Único de Saúde - Quixadá - Ceará, na perspectiva da política. Tratou-se de um estudo qualitativo, descritivo, desenvolvido nas Unidades básicas de saúde e contou com a participação de 3 gestores, 12 profissionais e 39 usuários, definidos por saturação teórica-empírica. A coleta de dados foi realizada mediante a entrevista semiestruturada no período de 07 de outubro à 28 de novembro de 2019 e analisados por Discurso do Sujeito Coletivo com base em Lefévre. Observou-se que ainda persiste um certo distanciamento das práticas humanizadas no contexto de saúde investigado com ênfase nas diretrizes estabelecidas pela Política de Humanização. (AU)

The Unified Health System, after its initial stages of guaranteeing access, building infrastructure, defining financing processes, introduced a qualitative dimension that was translated by the National Policy for the Humanization of Health Care and Management. The research aimed to understand the health humanization in primary care in the Unified Health System - Quixadá- Ceará, from the politics perspective. It was a qualitative, descriptive study, developed in the Basic Health Units and had the participation of 3 managers, 12 professionals and 39 users, defined by theoretical-empirical saturation. Data collection was carried out by means of a semi-structured interview from October 7 to November 28, 2019 and analyzed by Collective Subject Discourse based on Lefévre. It was observed that there is still a certain distance from humanized practices in the health context investigated with an emphasis on the guidelines established by the Humanization Policy. (AU)

Troxerutin Prevents 5-Fluorouracil Induced Morphological Changes in the Intestinal Mucosa: Role of Cyclooxygenase-2 Pathway.

Intestinal mucositis is a common complication associated with 5-fluorouracil (5-FU), a chemotherapeutic agent used for cancer treatment. Troxerutin (TRX), a semi-synthetic flavonoid extracted from Dimorphandra gardneriana, has been reported as a potent antioxidant and anti-inflammatory agent. In the present study, we aimed to evaluate the effect of TRX on 5-FU-induced intestinal mucositis. Swiss mice were randomly divided into seven groups: Saline, 5-FU, TRX-50, TRX-100, TRX-150, Celecoxib (CLX), and CLX + TRX-100. The weight of mice was measured daily. After treatment, the animals were euthanized and segments of the small intestine were collected to evaluate histopathological alterations (morphometric analysis), levels of malondialdehyde (MDA), myeloperoxidase (MPO), glutathione (GSH), mast and goblet cell counts, immunohistochemical analysis, and cyclooxygenase-2 (COX-2) activity. Compared to the saline treatment, the 5-FU treatment induced intense weight loss and reduction in villus height. TRX treatment (100 mg/kg) prevented the 5-FU-induced histopathological changes and decreased oxidative stress by decreasing the MDA levels and increasing GSH concentration. TRX attenuated inflammatory process by decreasing MPO activity, intestinal mastocytosis, and COX-2 expression. TRX also reversed the depletion of goblet cells. Our findings suggest that TRX at a concentration of 100 mg/kg had chemopreventive effects on 5-FU-induced intestinal mucositis via COX-2 pathway.

Physiological quality of bean seeds after application of desiccant herbicides / Qualidade fisiológica de sementes de feijão após aplicação de herbicidas dessecantes

The application of desiccant herbicides in the bean crop is fundamental in the production of quality seeds, since it anticipates the harvesting season, which makes it possible to obtain seeds in the period of physiological maturation, when they are reported with maximum accumulation of dry matter, high vigor levels and germination percentage. However, there is little information about the ideal application time of these products to obtain beans of high physiological quality. Therefore, the objective of this study was to evaluate the physiological quality of bean seeds after application of desiccant herbicides at different times in preharvest. The experimental design was a randomized complete block design in a 2x3+1 factorial scheme, with four replications. Desiccant herbicides paraquat (400g ha-1) and paraquat + diuron (200 + 400g ha-1) were applied in three phenological stages (R8, R8/R9 and R9), plus one control (without herbicide application). Yield (Kg ha-1), mass of one thousand seeds (g), germination (%) and seed vigor were evaluated through tests of accelerated aging, electrical conductivity and primary root length. Application of paraquat molecule at the R8 stage and the paraquat + diuron mixture at the R8/R9 stage reduced the viability and vigor of the bean seeds, and compromised yield. Applications of the paraquat herbicide at the R8/R9 and R9 stages or of the mixture (paraquat + diuron) at the R9 stage preserved the physiological quality of the seeds without; however, affecting yield.(AU)

A aplicação de herbicidas dessecantes na cultura do feijoeiro é fundamental na produção de sementes de qualidade porque antecipa a época de colheita, o que possibilita a obtenção de sementes no período de maturação fisiológica, quando se encontram com máximo acúmulo de matéria seca, elevados níveis de vigor e alta porcentagem de germinação. Todavia, são escassas as informações acerca da época ideal de aplicação desses produtos na obtenção de sementes de feijão de alta qualidade fisiológica. Por essa razão, objetivou-se avaliar a qualidade fisiológica de sementes de feijão após aplicações de herbicidas dessecantes em diferentes épocas na pré-colheita. O delineamento experimental utilizado foi o de blocos casualizados dispostos em esquema fatorial 2x3+1, com quatro repetições. A aplicação dos herbicidas dessecantes paraquat (400g ha-1) e paraquat + diuron (200+400g ha-1) foi realizada em três estádios fenológicos (R8, R8/R9 e R9), mais uma testemunha (sem aplicação do herbicida). Avaliou-se a produtividade (Kg ha-1), a massa de mil sementes (g), a germinação (%) e o vigor das sementes por meio dos testes de envelhecimento acelerado, condutividade elétrica e comprimento da raiz primária. A aplicação da molécula de paraquat no estádio R8 e da mistura paraquat + diuron no estágio R8/R9 reduziu a viabilidade e o vigor das sementes de feijão, além disso comprometeu a produtividade. Aplicações dos herbicidas paraquat nos estádios R8/R9 e R9 ou da mistura (paraquat + diuron) no estádio R9 preservaram a qualidade fisiológica das sementes, sem, entretanto, afetar a produtividade.(AU)

Physiological quality of bean seeds after application of desiccant herbicides / Qualidade fisiológica de sementes de feijão após aplicação de herbicidas dessecantes

ABSTRACT: The application of desiccant herbicides in the bean crop is fundamental in the production of quality seeds, since it anticipates the harvesting season, which makes it possible to obtain seeds in the period of physiological maturation, when they are reported with maximum accumulation of dry matter, high vigor levels and germination percentage. However, there is little information about the ideal application time of these products to obtain beans of high physiological quality. Therefore, the objective of this study was to evaluate the physiological quality of bean seeds after application of desiccant herbicides at different times in preharvest. The experimental design was a randomized complete block design in a 2x3+1 factorial scheme, with four replications. Desiccant herbicides paraquat (400g ha-1) and paraquat + diuron (200 + 400g ha-1) were applied in three phenological stages (R8, R8/R9 and R9), plus one control (without herbicide application). Yield (Kg ha-1), mass of one thousand seeds (g), germination (%) and seed vigor were evaluated through tests of accelerated aging, electrical conductivity and primary root length. Application of paraquat molecule at the R8 stage and the paraquat + diuron mixture at the R8/R9 stage reduced the viability and vigor of the bean seeds, and compromised yield. Applications of the paraquat herbicide at the R8/R9 and R9 stages or of the mixture (paraquat + diuron) at the R9 stage preserved the physiological quality of the seeds without;however, affecting yield.

RESUMO: A aplicação de herbicidas dessecantes na cultura do feijoeiro é fundamental na produção de sementes de qualidade porque antecipa a época de colheita, o que possibilita a obtenção de sementes no período de maturação fisiológica, quando se encontram com máximo acúmulo de matéria seca, elevados níveis de vigor e alta porcentagem de germinação. Todavia, são escassas as informações acerca da época ideal de aplicação desses produtos na obtenção de sementes de feijão de alta qualidade fisiológica. Por essa razão, objetivou-se avaliar a qualidade fisiológica de sementes de feijão após aplicações de herbicidas dessecantes em diferentes épocas na pré-colheita. O delineamento experimental utilizado foi o de blocos casualizados dispostos em esquema fatorial 2x3+1, com quatro repetições. A aplicação dos herbicidas dessecantes paraquat (400g ha-1) e paraquat + diuron (200+400g ha-1) foi realizada em três estádios fenológicos (R8, R8/R9 e R9), mais uma testemunha (sem aplicação do herbicida). Avaliou-se a produtividade (Kg ha-1), a massa de mil sementes (g), a germinação (%) e o vigor das sementes por meio dos testes de envelhecimento acelerado, condutividade elétrica e comprimento da raiz primária. A aplicação da molécula de paraquat no estádio R8 e da mistura paraquat + diuron no estágio R8/R9 reduziu a viabilidade e o vigor das sementes de feijão, além disso comprometeu a produtividade. Aplicações dos herbicidas paraquat nos estádios R8/R9 e R9 ou da mistura (paraquat + diuron) no estádio R9 preservaram a qualidade fisiológica das sementes, sem, entretanto, afetar a produtividade.

Poluição difusa nas águas pluviais de uma bacia de drenagem urbana / Diffuse pollution of storm water runoff from an urban catchment

RESUMO Este trabalho teve como objetivo avaliar a primeira carga de lavagem de uma bacia urbana da cidade de Natal, Rio Grande do Norte, por meio da quantificação de cargas poluentes contidas nos deflúvios superficiais em decorrência de nove eventos de precipitação pluviométrica, monitorados ao longo do ano de 2013. As variáveis analisadas foram: sólidos totais, sólidos suspensos totais, demanda química de oxigênio, fósforo total e teor de óleos e graxas. Foi realizada a avaliação dos eventos de precipitação/escoamento, mediante amostragem progressiva do runoff, monitorado por meio de amostrador automático (ISCO 6712), situado no exutório da bacia, sendo analisados os primeiros 24 minutos do escoamento superficial, com amostras coletadas a cada minuto ao longo do evento. A variação da concentração dos poluentes associada à variação temporal dos deflúvios durante eventos de precipitação foi analisada para a verificação da ocorrência do fenômeno first flush ou primeira carga de lavagem. O período monitorado caracterizou-se por apresentar baixo intervalo de dias de estiagem entre os eventos. Foi observada a ocorrência de primeira carga de lavagem em cinco dos eventos monitorados. Dessa forma, evidenciou-se que para a bacia estudada o conceito de first flush pode ser aplicado nas estratégias de manejo de águas pluviais, para implementação de boas práticas de manejo, que vêm sendo amplamente difundidas no que concerne à drenagem urbana.

ABSTRACT The aim of this study was to evaluate the first wash load of an urban catchment located in the city of Natal, Rio Grande do Norte, Brazil, by quantifying pollution loads contained in surface run-offs from nine rainfall events, monitored throughout the year 2013. The variables analyzed were: total solids, total suspended solids, chemical oxygen demand, total phosphorus and oil and grease content. We conducted the evaluation of precipitation/runoff events through progressive sampling of runoff, monitored by autosampler (ISCO 6712), and located at the outlet of the drainage basin. The first 24 minutes of runoff were analyzed, with samples collected every minute throughout the event. The variation of the pollutants concentration associated with the temporal run-offs variation during precipitation was analyzed to verify the occurrence of the first flush phenomenon. The monitored period was characterized by having a low number of drought days between events. The occurrence of the first flush was observed in five of the monitored events. Thus, it became clear that for the studied basin, the concept of first flush could be applied in rainwater management strategies for the implementation of best management practices, which have been widely disseminated regarding urban drainage.

Equine infectious anemia prevalence in feral donkeys from Northeast Brazil.

Equine infectious anemia virus (EIAV) is an important cause of morbidity and mortality throughout the world. Although the virus infects all members of the Equidae the vast majority of studies have been conducted in horses (Equus caballus) with comparatively little information available for other equid species. Brazil has one of the most abundant donkey (E. asinus) populations of any nation although the economic importance of these animals is declining as transportation becomes increasingly mechanized. As a result, considerable numbers of donkeys especially in the Northeast of the country have been released and allowed pursue an almost feral existence. Consequently, this large and growing population constitutes a significant risk as a reservoir for the maintenance and transmission of important equine infectious diseases such as glanders and equine arteritis virus in addition to EIAV. This study examines the prevalence of EIA in a semi-wild donkey population from Mossoró city, in Northeast Brazil, using AGID followed by cELISA, rgp90 ELISA and immunoblot (IB). Serum samples were collected from 367 donkeys without obvious EIA clinical signs. Subsequent testing revealed seropositive rates of 1.6% (6/367) in officially approved AGID tests, 3.3% (12/367) in cELISA and 14.4% (53/367) in the rgp90 ELISA. However, 88.7% (47/53) of the rgp90 ELISA positive samples were almost certainly false reactions because they failed to react with two or more antigens in IB. Consequently, the rpg90 ELISA has a similar sensitivity to AGID with donkey serum samples. Such high false positive rates have not been observed previously with serum samples from horses. Another highly significant finding is that 56.9% (33/58) of the donkey serum samples tested in IB had reactivity to EIAV p26 only. Although this could result from recent infection with the virus, it has been found that in some equids p26 only reactivity persists for extensive periods of time suggesting exposure to antigens possessing cross-reactive determinants or EIAV strains with envelope glycoproteins that are different from any that have been previously characterized and so undetectable by current IB techniques.

Heart fossilization is possible and informs the evolution of cardiac outflow tract in vertebrates.

Elucidating cardiac evolution has been frustrated by lack of fossils. One celebrated enigma in cardiac evolution involves the transition from a cardiac outflow tract dominated by a multi-valved conus arteriosus in basal actinopterygians, to an outflow tract commanded by the non-valved, elastic, bulbus arteriosus in higher actinopterygians. We demonstrate that cardiac preservation is possible in the extinct fish Rhacolepis buccalis from the Brazilian Cretaceous. Using X-ray synchrotron microtomography, we show that Rhacolepis fossils display hearts with a conus arteriosus containing at least five valve rows. This represents a transitional morphology between the primitive, multivalvar, conal condition and the derived, monovalvar, bulbar state of the outflow tract in modern actinopterygians. Our data rescue a long-lost cardiac phenotype (119-113 Ma) and suggest that outflow tract simplification in actinopterygians is compatible with a gradual, rather than a drastic saltation event. Overall, our results demonstrate the feasibility of studying cardiac evolution in fossils.

Field and experimental symptomless infections support wandering donkeys as healthy carriers of Trypanosoma vivax in the Brazilian Semiarid, a region of outbreaks of high mortality in cattle and sheep.

BACKGROUND: The Brazilian Semiarid is the home of the largest herd of donkeys in South America and of outbreaks of Trypanosoma vivax infection of high mortality in dairy cattle and sheep. For a comprehensive understanding of the underlying mechanisms of these outbreaks and epidemiological role of donkeys, we surveyed for T. vivax in wandering donkeys and follow the experimental infection of donkeys and sheep with a highly virulent isolate from the Semiarid. METHODS: Blood samples from 180 randomly selected wandering donkeys from the Brazilian Semiarid region were employed for PCV and parasitemia assessments and tested using the T. vivax-specific TviCATL-PCR assay. PCR-amplifed Cathepsin L (CATL) sequences were employed for genotyping and phylogenetic analysis. Four wandering donkeys were experimentally infected with a T. vivax isolate obtained during an outbreak of high mortality in the Semiarid; the control group consisted of two non-inoculated donkeys. RESULTS: We detected T. vivax in 30 of 180 wandering donkeys (16.6 %) using TviCATL-PCR. The prevalence was higher during the dry (15.5 %) than the wet season (1.1 %) and more females (23.1 %) than males (8.9 %) were infected. All the PCR-positive donkeys lacked patent parasitemia and showed normal values of body condition score (BCS) and packed cell volume (PCV). To evaluate the probable tolerance of donkeys to T. vivax, we inoculated five donkeys with a highly virulent isolate (TviBrRp) from the Semiarid. All inoculated donkeys became PCR-positive, but their parasitemia was always subpatent. A control goat inoculated with TviBrRp showed increasing parasitemia concurrently with fever, declining PCV, tachycardia, mucous membrane pallor, enlarged lymph nodes and anorexia. None of these signs were observed in donkeys. However, T. vivax from wandering donkeys shared identical or highly similar genotypes (identified by Cathepsin L sequences) with isolates from cattle and sheep outbreaks of acute disease in the Semiarid. CONCLUSIONS: This is the first report of T. vivax in donkeys in Brazil and, to our knowledge, the first experimental infection of donkeys with T. vivax. The symptomless field and experimental infections corroborated that donkeys are more tolerant to T. vivax than other livestock species as shown in African countries. Therefore, farmers, veterinaries and control programmes should be aware of healthy carrier donkeys as a possible source of T. vivax for susceptible livestock species in the Brazilian Semiarid.

A Mesozoic bird from Gondwana preserving feathers.

The fossil record of birds in the Mesozoic of Gondwana is mostly based on isolated and often poorly preserved specimens, none of which has preserved details on feather anatomy. We provide the description of a fossil bird represented by a skeleton with feathers from the Early Cretaceous of Gondwana (NE Brazil). The specimen sheds light on the homology and 3D structure of the rachis-dominated feathers, previously known from two-dimensional slabs. The rectrices exhibit a row of rounded spots, probably corresponding to some original colour pattern. The specimen supports the identification of the feather scapus as the rachis, which is notably robust and elliptical in cross-section. In spite of its juvenile nature, the tail plumage resembles the feathering of adult individuals of modern birds. Documentation of rachis-dominated tail in South American enantiornithines broadens the paleobiogeographic distribution of basal birds with this tail feather morphotype, up to now only reported from China.

Alterações periodontais após a radioterapia de carcinoma orofaríngeo ou da cavidade oral / Periodontal breakdown after radiotherapy for oral cavity or oropharyngeal carcinoma

Alteração periodontal foi descrita após a radioterapia de cabeça e pescoço para o tratamento de carcinomas. No entanto, não se sabe se os pacientes submetidos à manutenção periodontal também mostram destruição periodontal. A incidência de destruição periodontal após a radioterapia de cabeça e pescoço foi avaliada em pacientes submetidos à manutenção periodontal. Descrição do caso: profundidade de sondagem (PS), nível clínico de inserção (NCI), recessão gengival (RG), índice de placa (IP), sangramento à sondagem (SS) e nível do osso alveolar (NOA) foram avaliados em seis pacientes em manutenção periodontal, antes e sete meses após a terapia de radiação. Observou-se aumento significativo na recessão gengival (de 0,6 mm a 0,8 mm; p=0,001) e redução no nível ósseo (de 6,1 mm a 7,0mm; p=0,05). Mudanças no NCI e PS não foram significativas (p > 0,05). Implicações clínicas: aumento da recessão gengival e perda óssea alveolar foram observados nos pacientes submetidos à radioterapia de cabeça e pescoço sob manutenção periodontal. Portanto, em pacientes submetidos à manutenção periodontal, alterações periodontais também podem ser esperadas com a radioterapia de cabeça e pescoço.

Growing corn for silage in no-tillage and conventional systems under differents periods of hydric defict / Milho para ensilagem cultivado nos sistemas de plantio direto e convencional sob efeito de veranico

Led-if this work aimed to evaluate the effect of Indian summer periods about the productivity of corn for silage grown in no-tillage and conventional systems.The experiment was conducted in split plots, distributed in randomized block design, and systems were evaluated plots of no-till and conventional tillage and subplots, six periods of dry spells (2, 6, 10, 14, 18 and 22 days) applied from the 34 days after planting, respectively.The crop was irrigated by drip, with individual control of the water supply in each sub-plot, for interruption of the water supply during periods of Indian summer, as well as the irrigation management outside the periods of Indian summer, which was carried out separately for each sub-plot, based on soil water tension, in order to allow for the measurement of water consumption in the cycle of culture.It was found that Indian summer periods of 6, 10, 14, 18 and 22 days reduced dry matter productivity of corn for silage in 8.74; 26.47; 42.5; 48.05 and 64.60% of no-till and in 16.42; 32.04; 47.38; 65.23 and 74.19% in conventional tillage, respectively. The no-tillige system reduced consumption and improved water use efficiency in the production of corn for silage, reduced losses caused by water deficit.(AU)

Conduziu-se este trabalho com objetivo de avaliar o efeito de períodos de veranico sobre a produtividade de milho para ensilagem cultivado nos sistemas de plantio direto e convencional. O experimento foi conduzido em esquema de parcelas subdivididas, distribuídas no delineamento de blocos casualizados, sendo que nas parcelas foram avaliados os sistemas de plantio direto e plantio convencional e nas subparcelas, seis períodos de veranicos (2, 6, 10, 14, 18 e 22 dias) aplicados a partir dos 34 dias após o plantio, respectivamente. A cultura foi irrigada por gotejamento, com controle individual do suprimento de água em cada subparcela, para interrupção do suprimento de água nos períodos de veranico, bem como o manejo da irrigação fora dos períodos de veranico, que foi realizado de modo diferenciado para cada subparcela, baseado na tensão de água no solo, de modo a permitir a medição do consumo de água no ciclo da cultura. Verificou-se que períodos de veranico de 6, 10, 14, 18 e 22 dias reduziram a produtividade de matéria seca de milho para ensilagem em 8,74; 26,47; 42,5; 48,05 e 64,60% no sistema de plantio direto e em 16,42; 32,04; 47,38; 65,23 e 74,19% no sistema de plantio convencional, respectivamente. O sistema de plantio direto reduziu o consumo e melhorou a eficiência no uso da água na produção de milho para ensilagem, reduzindo as perdas provocadas por déficit hídrico.(AU)

Chemical identification and evaluation of the antimicrobial activity of fixed oil extracted from Rhinella jimi.

CONTEXT: The toad Rhinella jimi (Stevaux, 2002) (Bufonidae) is used in traditional medicine to treat a number of illnesses (inflammation, infections, and wounds) in humans as well as animals. OBJECTIVES: The present work examined the antimicrobial actions of the extracted oils from the body fat of R. jimi (ORJ) against fungi and standard and multi-resistant lines of bacteria, as well as their effects when combined with aminoglycosides. MATERIALS AND METHODS: The toads were collected in the municipality of Exu in Pernambuco State, Brazil, and their body fat oils extracted in a Soxhlet apparatus using hexane. A gas chromatograph coupled to a mass spectrometer was used to identify the fatty acids, based on their methyl esters. The antimicrobial activities of the oil were analyzed against standard and multi-resistant lines of Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, as well as against fungal lines of Candida albicans and Candida krusei using the broth micro-dilution method. RESULTS: The minimum inhibitory concentrations (MIC) of ORJ were 512 µg/mL for Candida krusei and ≥1024 µg/mL for the other microorganisms. When associated with amikacin, ORJ demonstrated an increase in its ability to inhibit E. coli growth (from 156.25 to 39.06 µg/mL), indicating synergistic interaction. In the same way, when allied with amikacin, gentamicin, and neomycin, the ORJ reduced the MICs meaningly, against P. aeruginosa. CONCLUSIONS: These data will enable searches to be made to obtain new products in combination with antibiotics, enhancing the efficacy of these drugs against drug-resistant microorganisms.

New Analysis Method Application in Metallographic Images through the Construction of Mosaics Via Speeded Up Robust Features and Scale Invariant Feature Transform.

In many applications in metallography and analysis, many regions need to be considered and not only the current region. In cases where there are analyses with multiple images, the specialist should also evaluate neighboring areas. For example, in metallurgy, welding technology is derived from conventional testing and metallographic analysis. In welding, these tests allow us to know the features of the metal, especially in the Heat-Affected Zone (HAZ); the region most likely for natural metallurgical problems to occur in welding. The expanse of the Heat-Affected Zone exceeds the size of the area observed through a microscope and typically requires multiple images to be mounted on a larger picture surface to allow for the study of the entire heat affected zone. This image stitching process is performed manually and is subject to all the inherent flaws of the human being due to results of fatigue and distraction. The analyzing of grain growth is also necessary in the examination of multiple regions, although not necessarily neighboring regions, but this analysis would be a useful tool to aid a specialist. In areas such as microscopic metallography, which study metallurgical products with the aid of a microscope, the assembly of mosaics is done manually, which consumes a lot of time and is also subject to failures due to human limitations. The mosaic technique is used in the construct of environment or scenes with corresponding characteristics between themselves. Through several small images, and with corresponding characteristics between themselves, a new model is generated in a larger size. This article proposes the use of Digital Image Processing for the automatization of the construction of these mosaics in metallographic images. The use of this proposed method is meant to significantly reduce the time required to build the mosaic and reduce the possibility of failures in assembling the final image; therefore increasing efficiency in obtaining results and expediting the decision making process. Two different methods are proposed: One using the transformed Scale Invariant Feature Transform (SIFT), and the second using features extractor Speeded Up Robust Features (SURF). Although slower, the SIFT method is more stable and has a better performance than the SURF method and can be applied to real applications. The best results were obtained using SIFT with Peak Signal-to-Noise Ratio = 61.38, Mean squared error = 0.048 and mean-structural-similarity = 0.999, and processing time of 4.91 seconds for mosaic building. The methodology proposed shows be more promissory in aiding specialists during analysis of metallographic images.

Growing corn for silage in no-tillage and conventional systems under differents periods of hydric defict / Milho para ensilagem cultivado nos sistemas de plantio direto e convencional sob efeito de veranico

Led-if this work aimed to evaluate the effect of Indian summer periods about the productivity of corn for silage grown in no-tillage and conventional systems.The experiment was conducted in split plots, distributed in randomized block design, and systems were evaluated plots of no-till and conventional tillage and subplots, six periods of dry spells (2, 6, 10, 14, 18 and 22 days) applied from the 34 days after planting, respectively.The crop was irrigated by drip, with individual control of the water supply in each sub-plot, for interruption of the water supply during periods of Indian summer, as well as the irrigation management outside the periods of Indian summer, which was carried out separately for each sub-plot, based on soil water tension, in order to allow for the measurement of water consumption in the cycle of culture.It was found that Indian summer periods of 6, 10, 14, 18 and 22 days reduced dry matter productivity of corn for silage in 8.74; 26.47; 42.5; 48.05 and 64.60% of no-till and in 16.42; 32.04; 47.38; 65.23 and 74.19% in conventional tillage, respectively. The no-tillige system reduced consumption and improved water use efficiency in the production of corn for silage, reduced losses caused by water deficit.

Conduziu-se este trabalho com objetivo de avaliar o efeito de períodos de veranico sobre a produtividade de milho para ensilagem cultivado nos sistemas de plantio direto e convencional. O experimento foi conduzido em esquema de parcelas subdivididas, distribuídas no delineamento de blocos casualizados, sendo que nas parcelas foram avaliados os sistemas de plantio direto e plantio convencional e nas subparcelas, seis períodos de veranicos (2, 6, 10, 14, 18 e 22 dias) aplicados a partir dos 34 dias após o plantio, respectivamente. A cultura foi irrigada por gotejamento, com controle individual do suprimento de água em cada subparcela, para interrupção do suprimento de água nos períodos de veranico, bem como o manejo da irrigação fora dos períodos de veranico, que foi realizado de modo diferenciado para cada subparcela, baseado na tensão de água no solo, de modo a permitir a medição do consumo de água no ciclo da cultura. Verificou-se que períodos de veranico de 6, 10, 14, 18 e 22 dias reduziram a produtividade de matéria seca de milho para ensilagem em 8,74; 26,47; 42,5; 48,05 e 64,60% no sistema de plantio direto e em 16,42; 32,04; 47,38; 65,23 e 74,19% no sistema de plantio convencional, respectivamente. O sistema de plantio direto reduziu o consumo e melhorou a eficiência no uso da água na produção de milho para ensilagem, reduzindo as perdas provocadas por déficit hídrico.