Qualitative and quantitative determination of xylazine in oral fluid.

Xylazine has emerged in recent years as a dangerous adulterant in illicit fentanyl use, and methods for the detection of xylazine in toxicology panels are still lagging. We developed methods for the screening and quantitation of xylazine in oral fluid (OF), a popular testing medium due to its ease of collection and reflection of presence in blood for many classes of drugs. Enzyme-linked immunosorbent assays were employed for the rapid screening of xylazine directly from the collection device buffer with a cutoff of 1 ng/mL. Solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry facilitated the confirmation and quantification of xylazine as low as 0.1 ng/mL and a dynamic range of 0.1-25 ng/mL. Selectivity, ionization suppression, processed sample stability, and dilution effect were also assessed. The method was validated through the American National Standards Institute/American Academy of Forensic Sciences Standards Board (ANSI/ASB) Standard 036, first edition from 2019, and found to be accurate, precise, and robust. Living human subject OF samples collected within substance use disorder and therapeutic drug monitoring clinics received between September 2023 and January 2024, with the specific request to test for xylazine (n = 57), were screened. Presumptive positive samples were confirmed using the validated method. Xylazine confirmed living human subject OF sample concentrations ranged from 1.2 to 23.3 ng/mL.

In-office dental bleaching in adolescents using 6% hydrogen peroxide with and without gingival barrier: a randomized double-blind clinical trial.

BACKGROUND: At low concentrations used for in-office bleaching gels, such as 6% HP, gingival barrier continues to be performed. If we take into account that, in the at-home bleaching technique, no barrier is indicated, it seems that the use of a gingival barrier fails to make much sense when bleaching gel in low concentration is used for in-office bleaching. OBJECTIVE: This double-blind, split-mouth, randomized clinical trial evaluated the gingival irritation (GI) of in-office bleaching using 6% hydrogen peroxide (HP) with and without a gingival barrier in adolescents, as well as color change and the impact of oral condition on quality of life. METHODOLOGY: Overall, 60 participants were randomized into which side would or would not receive the gingival barrier. In-office bleaching was performed for 50 minutes with 6% HP in three sessions. The absolute risk and intensity of GI were assessed with a visual analogue scale. Color change was assessed using a digital spectrophotometer and color guides. The impact of oral condition on quality of life was assessed using the Brazilian version of the Oral Health Impact Profile (α=0.05). RESULTS: The proportion of patients who presented GI for the "with barrier" group was 31.6% and for the "without barrier" group, 30% (p=1.0). There is an equivalence for the evaluated groups regarding GI intensity (p<0.01). Color change was detected with no statistical differences (p>0.29). There was a significant impact of oral condition on quality of life after bleaching (p<0.001). CONCLUSIONS: The use or not of the gingival barrier for in-office bleaching with 6% HP was equivalent for GI, as well as for bleaching efficacy, with improvement in the impact of oral condition on quality of life.

In-office dental bleaching in adolescents using 6% hydrogen peroxide with and without gingival barrier: a randomized double-blind clinical trial

Abstract At low concentrations used for in-office bleaching gels, such as 6% HP, gingival barrier continues to be performed. If we take into account that, in the at-home bleaching technique, no barrier is indicated, it seems that the use of a gingival barrier fails to make much sense when bleaching gel in low concentration is used for in-office bleaching. Objective This double-blind, split-mouth, randomized clinical trial evaluated the gingival irritation (GI) of in-office bleaching using 6% hydrogen peroxide (HP) with and without a gingival barrier in adolescents, as well as color change and the impact of oral condition on quality of life. Methodology Overall, 60 participants were randomized into which side would or would not receive the gingival barrier. In-office bleaching was performed for 50 minutes with 6% HP in three sessions. The absolute risk and intensity of GI were assessed with a visual analogue scale. Color change was assessed using a digital spectrophotometer and color guides. The impact of oral condition on quality of life was assessed using the Brazilian version of the Oral Health Impact Profile (α=0.05). Results The proportion of patients who presented GI for the "with barrier" group was 31.6% and for the "without barrier" group, 30% (p=1.0). There is an equivalence for the evaluated groups regarding GI intensity (p<0.01). Color change was detected with no statistical differences (p>0.29). There was a significant impact of oral condition on quality of life after bleaching (p<0.001). Conclusions The use or not of the gingival barrier for in-office bleaching with 6% HP was equivalent for GI, as well as for bleaching efficacy, with improvement in the impact of oral condition on quality of life.

Custo-utilidade da utilização de teste farmacogenético como guia para o tratamento de depressão sob a perspectiva do Sistema de Saúde Suplementar / Cost-utility of pharmacogenetic testing as a guide for the treatment of depression from the Brazilian Supplementary Health System perspective

Objetivo: Desenvolver uma análise de custo-utilidade da implementação do teste farmacogenético como uma ferramenta adicional para orientar a escolha do melhor tratamento medicamentoso para indivíduos com depressão. Métodos: Para a realização desta análise, criou-se um modelo analítico de decisão baseado em um modelo de Markov. A avaliação foi realizada sob a perspectiva do Sistema de Saúde Suplementar brasileiro, com horizonte temporal de 10 anos, incluindo custos médicos diretos e custos da tecnologia utilizada, além de ter como comparador o tratamento empírico tradicional para a depressão. As probabilidades de transição foram obtidas por meio de análise da literatura disponível. Também foram realizadas análises de sensibilidade probabilística e univariada. Adicionalmente, foi realizada uma avaliação sob a perspectiva da sociedade, incluindo os custos de tratamento medicamentoso realizados pelos pacientes. Resultados: De acordo com a análise realizada, o emprego do teste farmacogenético como guia do tratamento para depressão mostrou-se favorável, proporcionando economia de -R$ 3.439,97 por paciente e aumento de 0,39 QALY ao longo do horizonte temporal. Assim, evidencia-se uma economia significativa a favor do teste farmacogenético, correspondendo a -R$ 8.776,78 por QALY salvo. Além disso, a robustez do modelo foi comprovada por meio das análises de sensibilidade. No cenário sob perspectiva da sociedade, o resultado foi ainda mais favorável, proporcionando economia de -R$ 9.381,49 por paciente e aumento de 0,39 QALY, correspondendo a -R$ 23.936,05 por QALY salvo. Conclusão: Os resultados encontrados neste estudo demonstraram que o uso de testes farmacogenéticos no tratamento da depressão é economicamente vantajoso, com aumento no valor de QALY e redução nos custos médicos diretos, em comparação ao tratamento empírico tradicional. Essa descoberta alinha-se à tendência atual de personalização no cuidado da saúde mental, sugerindo implicações práticas na reavaliação de protocolos, com potencial incorporação dos testes farmacogenéticos como padrão de cuidado.

Objective: To evaluate the cost-utility of pharmacogenetic testing incorporation as an additional tool in guiding the selection of optimal drug treatments for individuals with depression. Methods: A decision analytical model was created based on the Markov model for this analysis. The evaluation was conducted from the perspective of the Brazilian Supplementary Health System, with a time horizon of 10 years. The study included direct medical and technology costs and a comparison with traditional empirical treatment for depression was performed. Transition probabilities were derived from an analysis of available literature. Probabilistic and univariate sensitivity analyses were also carried out. Additionally, an evaluation was conducted from the perspective of Society, including the costs of drug treatment carried out by patients. Results: The application of pharmacogenetic testing as a guide for depression treatment demonstrated favorable outcomes, yielding savings of -R$ 3,439.97 per patient and an increase of 0.39 QALY over the specified time frame. Thus, significant savings were evident, corresponding to -R$ 8,776.78 per QALY saved. The sensitivity analyses confirmed the model's robustness. In the Society's perspective scenario, the outcome was even more favorable, resulting in savings of -R$ 9,381.49 per patient and a 0.39 increase in QALYs, equivalent to -R$ 23,936.05 per QALY saved. Conclusion: The study findings reveal that incorporating harmacogenetic tests in depression treatment offers economic benefits, evidenced by an increase in QALY value and a decrease in direct medical costs compared to conventional empirical treatment. This aligns with the ongoing trend towards personalized mental health care, implying practical considerations for protocol reassessment and the possible integration of pharmacogenetic tests as a standard of care.

Diagnóstico das práticas de produção de queijos artesanais por pequenos produtores em um assentamento rural / Diagnosis of production practices of artisan cheeses by small producers in a rural settlement

Dentre os produtos artesanais existentes, o queijo frescal é um dos mais apreciados e que por ser muito manipulado, é passível de contaminações físicas, químicas e microbiológicas. Este estudo visou diagnosticar as práticas de produção feitas por pequenos produtores rurais e identificar os principais entraves para alcance da segurança do alimento. Foi aplicado questionário estruturado em 66% dos produtores de leite e queijo e os resultados mostraram que havia falhas no processo de ordenha, na produção do queijo, na embalagem e na rotulagem dos queijos obtidos. Assim, concluiu-se haver necessidade, em curto prazo, de realização de um treinamento para a produção de queijos com segurança para a saúde do consumidor.

Evaluation of Postural Balance and Articular Mobility of the Lower Limbs in Chronic Neck Pain Patients by Means of Low-Cost Clinical Tests.

OBJECTIVE: The purpose of this study was to correlate measurements of chronic neck pain with the balance and mobility of the lower limbs and to compare these variables between individuals with chronic neck pain and asymptomatic participants. METHODS: This was a blinded cross-sectional study. Participants with chronic neck pain (n = 30) and asymptomatic participants (n = 30) were included in the study. To measure pain in the neck region, the Numeric Rating Scale, Neck Disability Index, and Pain-Related Catastrophizing Thoughts Scale were applied. The assessment of postural balance and mobility of the lower limbs was made using the Timed Up and Go Test, Functional Reach Test (FRT), Lateral Reach Test, and 30-second Chair Stand Test. RESULTS: No statistically (P > .05) and clinically (d < 0.50) significant differences were identified for the variables tested here. However, regarding the correlations, a significant association was identified only between the intensity of pain during cervical movements and FRT (r = -0.312). CONCLUSION: Young adults with chronic neck pain present changes in static balance measured by means of the FRT; that is, the higher the intensity of pain, the lower the anteroposterior excursion of the body during the execution of the test.

Doença de Still como causa de febre de origem indeterminada: relato de caso / Still's disease as a cause of fever of undetermined origin: case report

POS, 22 anos, sexo feminino, foi admitida na enfermaria de Clínica Médica para investigação diagnóstica de quadro consumptivo. Queixava-se perda ponderal (45 kg no total), febre vespertina, artralgias e hiporexia.Relatava internações recorrentes devido a fraqueza. Na história pregressa constava aborto espontâneo, tendo sido aventada a hipótese de infecção pelo zika vírus, porém não foram realizados exames sorológicos confirmatórios.Tinha contato com irmão portador de paracoccidioidomicose e tio com tuberculose. Apresentava-se emagrecida,com flacidez notável, sarcopenia, palidez cutânea mucosa grave, linfadenomegalia generalizada e hepatoesplenomegalia. Diante do quadro clínico, suspeitou-se inicialmente de doença linfoproliferativa. Apresentou anemia microcítica e hipocrômica, sorologias negativas para HIV, sífilis, leishmaniose e hepatites virais, FAN positivo, padrão nuclear pontilhado, PCR e VSH elevados, leucocitose e ferritina maior que 2000 em dois exames. O PPD era não reator. Os anatomopatológicos apresentavam pesquisa negativa para fungos e parasitas e sugeriam doença linfoproliferativa,entretanto as imunohistoquímicas revelaram padrão de linfonodos reacionais. Devido à suspeita inicial de doença linfoproliferativa foi iniciado profilaxia para lise tumoral com hidratação e alopurinol.Além disso devido as diversas linfonodomegalias foi iniciado tratamento empírico com Prednisona 80 mg/dia, com melhora do quadro clínico, remissão da febre e artralgia. Como os anatomopatológicos e imunohistoquímicas descartaram doenças proliferativas, foi iniciado desmame do corticoide, com ressurgimento da febre, dessa vez acompanhada de rash cutâneo evanescente em membros e artrite em joelho direito. Após afastar doenças infecciosas, neoplásicas e outras etiologias, considerou-se o diagnóstico de doença de Still, uma vez que a paciente apresentava quadro clínico compatível e preenchia os critérios de Yamaguchi. Iniciada terapia com metotrexate, com melhora do quadro clínico e alta hospitalar. (AU)

POS, 22 years old, female, was admitted for a diagnostic investigation of the consumptive condition. Weight loss (45 in total), afternoon fever, arthralgia and hyporexia were noted. Reported recurrent hospitalizations due to weakness. Previous history consisted of spontaneous abortion, having been hypothesized to be infected by zika virus, but no confirmatory serological tests were performed. He had contact with a brother with paracoccidioidomycosis and uncle with tuberculosis. He was emaciated, with remarkable flaccidity, sarcopenia, severe mucosal skin paleness, generalized lymphadenomegaly and hepatosplenomegaly. In the clinical picture, lymphoproliferative disease was initially suspected. It presented microcytic and hypochromic anemia, HIV negative serology, syphilis, leishmaniasis and viral hepatitis, (PPS) was not a reactor. The anatomopathologicals presented negative research for fungi and parasites and suggested lymphoproliferative disease. However, immunohistochemistry revealed a pattern of reactional lymph nodes. Due to the initial suspicion of lymphoproliferative disease, prophylaxis was started for tumoral lysis with hydration and allopurinol. In addition, due to the various lymph node metastasis, empiric treatment with Prednisone 80 mg / day was initiated, with improvement of the clinical picture, remission of fever and arthralgia. and immunohistochemistry discarded proliferative diseases, weaning of the corticosteroid was started, with a resurgence of fever, this time accompanied by evanescent cutaneous rash in limbs and right knee arthritis. After eliminating infectious, neoplastic and other etiologies diseases, it was considered the diagnosis of Still, once the patient presented a compatible clinical picture and fulfilled Yamaguchi criteria. Initiated therapy with methotrexate, with improvement of the clinical picture and hospital discharge. (AU)

Spatial analysis of avoidable hospitalizations due to tuberculosis in Ribeirao Preto, SP, Brazil (2006-2012).

OBJECTIVE: To describe the spatial distribution of avoidable hospitalizations due to tuberculosis in the municipality of Ribeirao Preto, SP, Brazil, and to identify spatial and space-time clusters for the risk of occurrence of these events. METHODS: This is a descriptive, ecological study that considered the hospitalizations records of the Hospital Information System of residents of Ribeirao Preto, SP, Southeastern Brazil, from 2006 to 2012. Only the cases with recorded addresses were considered for the spatial analyses, and they were also geocoded. We resorted to Kernel density estimation to identify the densest areas, local empirical Bayes rate as the method for smoothing the incidence rates of hospital admissions, and scan statistic for identifying clusters of risk. Softwares ArcGis 10.2, TerraView 4.2.2, and SaTScan™ were used in the analysis. RESULTS: We identified 169 hospitalizations due to tuberculosis. Most were of men (n = 134; 79.2%), averagely aged 48 years (SD = 16.2). The predominant clinical form was the pulmonary one, which was confirmed through a microscopic examination of expectorated sputum (n = 66; 39.0%). We geocoded 159 cases (94.0%). We observed a non-random spatial distribution of avoidable hospitalizations due to tuberculosis concentrated in the northern and western regions of the municipality. Through the scan statistic, three spatial clusters for risk of hospitalizations due to tuberculosis were identified, one of them in the northern region of the municipality (relative risk [RR] = 3.4; 95%CI 2.7-4,4); the second in the central region, where there is a prison unit (RR = 28.6; 95%CI 22.4-36.6); and the last one in the southern region, and area of protection for hospitalizations (RR = 0.2; 95%CI 0.2-0.3). We did not identify any space-time clusters. CONCLUSIONS: The investigation showed priority areas for the control and surveillance of tuberculosis, as well as the profile of the affected population, which shows important aspects to be considered in terms of management and organization of health care services targeting effectiveness in primary health care.

Spatial analysis of avoidable hospitalizations due to tuberculosis in Ribeirao Preto, SP, Brazil (2006-2012) / Análise espacial das internações evitáveis por tuberculose em Ribeirão Preto, SP (2006-2012)

ABSTRACT OBJECTIVE To describe the spatial distribution of avoidable hospitalizations due to tuberculosis in the municipality of Ribeirao Preto, SP, Brazil, and to identify spatial and space-time clusters for the risk of occurrence of these events. METHODS This is a descriptive, ecological study that considered the hospitalizations records of the Hospital Information System of residents of Ribeirao Preto, SP, Southeastern Brazil, from 2006 to 2012. Only the cases with recorded addresses were considered for the spatial analyses, and they were also geocoded. We resorted to Kernel density estimation to identify the densest areas, local empirical Bayes rate as the method for smoothing the incidence rates of hospital admissions, and scan statistic for identifying clusters of risk. Softwares ArcGis 10.2, TerraView 4.2.2, and SaTScanTM were used in the analysis. RESULTS We identified 169 hospitalizations due to tuberculosis. Most were of men (n = 134; 79.2%), averagely aged 48 years (SD = 16.2). The predominant clinical form was the pulmonary one, which was confirmed through a microscopic examination of expectorated sputum (n = 66; 39.0%). We geocoded 159 cases (94.0%). We observed a non-random spatial distribution of avoidable hospitalizations due to tuberculosis concentrated in the northern and western regions of the municipality. Through the scan statistic, three spatial clusters for risk of hospitalizations due to tuberculosis were identified, one of them in the northern region of the municipality (relative risk [RR] = 3.4; 95%CI 2.7-4,4); the second in the central region, where there is a prison unit (RR = 28.6; 95%CI 22.4-36.6); and the last one in the southern region, and area of protection for hospitalizations (RR = 0.2; 95%CI 0.2-0.3). We did not identify any space-time clusters. CONCLUSIONS The investigation showed priority areas for the control and surveillance of tuberculosis, as well as the profile of the affected population, which shows important aspects to be considered in terms of management and organization of health care services targeting effectiveness in primary health care.

RESUMO OBJETIVO Descrever a distribuição espacial dos casos de internações evitáveis por tuberculose no município de Ribeirão Preto, SP, e identificar aglomerados espaciais e espaço-temporais de risco para a ocorrência desses eventos. MÉTODOS Estudo descritivo e ecológico que considerou os registros de internações no Sistema de Informação Hospitalar dos residentes de Ribeirão Preto, SP, no período de 2006 a 2012. Para as análises espaciais foram considerados somente os casos com endereços registrados, sendo os mesmos geocodificados. Recorreu-se à estatística de densidade Kernel para identificar as áreas de maior densidade, taxa bayesiana empírica local como método de suavização das taxas de incidência de internações e estatística de varredura para identificação de aglomerados de risco. Para as análises foram utilizados os softwares ArcGis 10.2, TerraView 4.2.2 e SaTScanTM. RESULTADOS Foram identificadas 169 internações por tuberculose. A maioria das internações ocorreu com pessoas do sexo masculino (n = 134; 79,2%) com idade mediana de 48 anos (DP = 16,2). A forma clínica predominante foi a pulmonar, com confirmação por exame microscópico da expectoração (n = 66; 39,0%). Foram geocodificados 159 (94,0%) casos. Observou-se distribuição espacial não aleatória de internações evitáveis por tuberculose, concentradas nas regiões norte e oeste do município. Por meio da estatística de varredura, identificaram-se três aglomerados espaciais de risco para internações por tuberculose, um na região norte do município (risco relativo [RR] = 3,4; IC95% 2,7-4,4); o segundo, na região central, onde há uma unidade prisional (RR = 28,6; IC95% 22,4-36,6); e o último, na região sul, área de proteção para as internações (RR = 0,2; IC95% 0,2-0,3). Não foram identificados aglomerados espaço-temporais. CONCLUSÕES A investigação mostrou áreas prioritárias para o controle e vigilância da tuberculose e um perfil de população atingida, evidenciando aspectos importantes a serem considerados em termos de gestão e organização dos serviços de saúde com vistas à efetividade da Atenção Primária à Saúde.

Factors associated with knowledge about tuberculosis and attitudes of relatives of patients with the disease in Ribeirão Preto, São Paulo, Brazil.

OBJECTIVE: To investigate the knowledge regarding tuberculosis among relatives of patients with tuberculosis and the possible factors associated with this event and also to conduct comparative analyses between groups of relatives with or with few knowledge regarding tuberculosis, considering their attitudes in both groups. METHODS: Cross-sectional study in which the sample was obtained through simple and randomized method. The data were collected by trained interviewers and validated tool. Logistic regression analyses were done using statistical software SPSS, version 22.0. RESULTS: Among the 110 subjects recruited for the study, 85 (87.5%) were women, and the mean age was 49 years. Regarding common symptoms of tuberculosis, 102 relatives (90.9%) pointed the chronic cough; regarding the knowledge about tuberculosis transmission modes, 100 (90.9%) of them pointed symptomatic respiratory as the probable infection source. The relatives also reported other tuberculosis transmission models: sharing of clothes (n = 87; 79.1%) and household utensils (n = 66; 60%); sexual relations (n = 50; 50%). Illiterate relatives (adjusted OR = 4.39; 95%CI 1.11 - 17.36), those who do not watch or watch little television (adjusted OR = 3.99; 95%CI 1.2 - 13.26), and also those who do not have the Internet access (adjusted OR = 5.01; 95%CI 1.29 - 19.38) were more likely to have low knowledge regarding tuberculosis. Regardless the group, with or without tuberculosis knowledge, the attitudes of both were satisfactory. CONCLUSION: There are evidences that social inequity is associated to the tuberculosis knowledge of patient relatives.

Factors associated with knowledge about tuberculosis and attitudes of relatives of patients with the disease in Ribeirão Preto, São Paulo, Brazil / Fatores associados ao conhecimento sobre tuberculose e atitudes das famílias de pacientes com a doença em Ribeirão Preto, São Paulo

To investigate the knowledge regarding tuberculosis among relatives of patients with tuberculosis and the possible factors associated with this event and also to conduct comparative analyses between groups of relatives with or with few knowledge regarding tuberculosis, considering their attitudes in both groups.

Investigar o conhecimento das famílias sobre tuberculose e os possíveis fatores associados a essa ocorrência, além de efetuar uma análise comparativa dos grupos de familiares com conhecimento ou com pouco conhecimento quanto às suas atitudes para com o paciente com tuberculose.

Estigma social e as famílias de doentes com tuberculose: um estudo a partir das análises de agrupamento e de correspondência múltipla / Social stigma and the families of patients with tuberculosis: a study based on cluster and multiple correspondence analysis

O estigma social da tuberculose é um desafio que se coloca à gestão do cuidado na área da saúde pública. O objetivo deste estudo foi investigar o estigma social em famílias de doentes com TB e identificar o perfil daquelas que são acometidas pelo evento em relação às condições socioeconômicas e demográficas. Trata-se de um estudo transversal realizado no município de Ribeirão Preto, São Paulo, Brasil, em 2011, com uma amostra de 110 sujeitos. Os dados foram analisados mediante técnica descritiva univariada e análises de agrupamento e de correspondência múltipla. Os grupos com estigma apresentaram baixa escolaridade, acesso incipiente aos meios de informação e pouca mobilização referente à compreensão sobre a doença, diferenciando-se dos demais grupos que apresentam comportamentos e atitudes positivas, com níveis de escolaridade mais elevados, acesso contínuo aos meios de informação e se dizem conhecedores da TB. A identificação de diferentes perfis aponta para necessidade de serem desenvolvidas ações em saúde sensíveis às singularidades das famílias no que se refere ao estigma social da doença.

The social stigma associated with TB is a challenge facing management of the area of public health care. The aim of this study was to investigate the social stigma in families of patients with TB and identify the profile of those who are affected by the event in relation to socioeconomic and demographic conditions. It is a cross-sectional study that was conducted in 2011 in the city of Ribeirão Preto, state of São Paulo, Brazil, with a sample of 110 individuals. The data were analyzed using the univariate descriptive technique and cluster and multiple correspondence assessment. The stigmatized groups tend to have lower scholarity, incipient access to the media and little understanding about TB, as opposed to those that have higher educational levels, continuous access to the media, consider themselves well informed and show proactive attitudes to deal with the disease. The identification of varied profiles highlights the need to develop health interventions to cater to the singularities of families with respect to the social stigma of the disease.

[Social stigma and the families of patients with tuberculosis: a study based on cluster and multiple correspondence analysis]. / Estigma social e as famílias de doentes com tuberculose: um estudo a partir das análises de agrupamento e de correspondência múltipla.

The social stigma associated with TB is a challenge facing management of the area of public health care. The aim of this study was to investigate the social stigma in families of patients with TB and identify the profile of those who are affected by the event in relation to socioeconomic and demographic conditions. It is a cross-sectional study that was conducted in 2011 in the city of Ribeirão Preto, state of São Paulo, Brazil, with a sample of 110 individuals. The data were analyzed using the univariate descriptive technique and cluster and multiple correspondence assessment. The stigmatized groups tend to have lower scholarity, incipient access to the media and little understanding about TB, as opposed to those that have higher educational levels, continuous access to the media, consider themselves well informed and show proactive attitudes to deal with the disease. The identification of varied profiles highlights the need to develop health interventions to cater to the singularities of families with respect to the social stigma of the disease.

[The families and directly observed treatment of tuberculosis: senses and prospects to the production of care]. / Famílias e o tratamento diretamente observado da tuberculose: sentidos e perspectivas para produção do cuidado.

The purpose was to identify the families' participation on care management of patients with tuberculosis. Also, to ascertain the contribution offered by health professionals for patients'families with ongoing treatment, and investigate the importance attributed by the families to the directly observed treatment It is a descriptive, cross-sectional study conducted in the municipality of Ribeirão Preto/SP with families of patients diagnosed with tuberculosis. For data collection, it was developed an instrument that underwent pretesting and content validation. Ninety four subjects were interviewed. According to the results, 64 (68.096) relatives participated in the care management and 81 (86.2%) reported a good relationship with the staff. Sixty three family members (67%) did not receive any guidance about drugs and 75 (80.0%) of the respondents considered the strategy as relevant. The findings indicate that the Directly Observed Treatment has limitations regarding the guidelines of clinical management of the disease, the inclusion of family in care management and understanding of its goals.

Living with CHD: quality of life (QOL) in early adult life.

AIMS: The aim of this study was to assess the quality of life, psychiatric morbidity, and the psychosocial adjustment of adolescents and young adults with CHD, and determine which variables play a role in buffering stress and promoting resilience and which ones have a detrimental effect; and to investigate the situation on school performance and failures, social and family support, physical limitations, and body image of these patients. METHODS: The study enrolled 137 CHD patients (79 male), with age ranging from 12 to 26 years old (M=17.60±3.450 years). The patients were interviewed regarding social support, family educational style, self-image, demographic information, and physical limitations. They responded to questions in a standardised psychiatric interview (SADS-L) and completed self-reported questionnaires for the assessment of quality of life (WHOQOL-BREF) and psychosocial adjustment (YSR/ASR). RESULTS: We found a 19.7% lifetime prevalence of psychopathology in our patients (27.6% in female and 13.9% in male). Of them, 48% had retentions in school (M=1.61 year±0.82). The perception of quality of life in CHD patients is better compared with the Portuguese population in the social relationships and environmental dimensions. However, it is worse in complex forms of CHD than in moderate-to-mild ones, in cyanotic versus acyanotic patients, in moderate-to-severe versus mild residual lesions, in patients submitted versus those not submitted to surgery, in patients with versus without physical limitations, and patients who have need for medication versus those who do not. Social support is very important in improving quality of life of patients in all dimensions as well as academic performance. CONCLUSIONS: Female patients and patients with poor academic performance and poor social support have worse psychosocial adjustment and perception of quality of life.

The families and directly observed treatment of tuberculosis: senses and prospects to the production of care / Las familias y el tratamiento directamente observado de la tuberculosis: sentidos y perspectivas para la producción del cuidado / Famílias e o tratamento diretamente observado da tuberculose: sentidos e perspectivas para produção do cuidado

The purpose was to identify the families' participation on care management of patients with tuberculosis. Also, to ascertain the contribution offered by health professionals for patients' families with ongoing treatment, and investigate the importance attributed by the families to the directly observed treatment. It is a descriptive, cross-sectional study conducted in the municipality of Ribeirão Preto/SP with families of patients diagnosed with tuberculosis. For data collection, it was developed an instrument that underwent pretesting and content validation. Ninety four subjects were interviewed. According to the results, 64 (68.0%) relatives participated in the care management and 81 (86.2%) reported a good relationship with the staff. Sixty three family members (67%) did not receive any guidance about drugs and 75 (80.0%) of the respondents considered the strategy as relevant. The findings indicate that the Directly Observed Treatment has limitations regarding the guidelines of clinical management of the disease, the inclusion of family in care management and understanding of its goals.

El objetivo fue identificar la participación de familiares en la gestión del cuidado del enfermo con tuberculosis, averiguar el aporte de los profesionales de la salud para las familias de pacientes en tratamiento e investigar la importancia atribuida por esas familias al tratamiento directamente observado. Estudio descriptivo, corte transversal y realizado en el municipio de Ribeirão Preto/SP con las familias de pacientes diagnosticados con tuberculosis. Para obtener los datos fue elaborado un instrumento que pasó por la validación del contenido y preexamen. Fueron entrevistados 94 sujetos. De acuerdo con los resultados, 64 (68,0%) de los familiares participaron de la gestión del cuidado; 81 (86,2%) relataron una buena relación con el equipo, 63 (67%) no recibieron orientación sobre medicamentos y 75 (80,0%) consideraron la estrategia como relevante. Los resultados señalan que el Tratamiento Directamente Observado presenta limitaciones sobre las orientaciones del manejo clínico de la enfermedad, la inclusión de la familia en la gestión del cuidado y en la comprensión de los objetivos.

O objetivo foi identificar a participação das famílias na gestão do cuidado do doente de tuberculose, o aporte oferecido pelos profissionais de saúde às famílias de doentes em tratamento e a importância atribuída pelas famílias ao Tratamento Diretamente Observado. Trata-se de um estudo descritivo de corte transversal, realizado no município de Ribeirão Preto, SP, junto às famílias dos pacientes diagnosticados de tuberculose. Para coleta de dados, foi elaborado um instrumento que passou pela validação de conteúdo e pré-teste. Foram entrevistados 94 sujeitos. Nos resultados, 64 (68,0%) dos familiares participaram da gestão do cuidado, 81 (86,2%) relataram boa relação com a equipe, 63 (67%) não receberam orientação dos medicamentos e 75 (80,0%) consideraram a estratégia como relevante. Os achados do estudo apontam que o Tratamento Diretamente Observado apresenta ainda limitações quanto às orientações do manejo clínico da doença, a inclusão da família na gestão do cuidado e na compreensão dos seus objetivos.

[Tuberculosis and social inequity in health: an ecological study using multivariate statistical techniques, São Paulo, Brazil]. / Tuberculose e iniquidade social em saúde: uma análise ecológica utilizando técnicas estatísticas multivariadas, São Paulo, Brasil.

OBJECTIVE: To identify the patterns of São Paulo state municipalities, in Brazil, regarding the relationship between tuberculosis and indicators of health care services, health care service availability, context, and social inequality. METHODS: This ecological study covered all 645 municipalities of São Paulo and eight variables belonging to three dimensions: health care service availability, context, and social inequality. Data were analyzed using hierarchical and non-hierarchical clustering, principal components analysis, and geoprocessing. RESULTS: The analysis revealed five groups of municipalities: group 1 (117 municipalities), with similar directly observed treatment (DOT) and family health strategy (FHS) coverage, high tuberculosis incidence and death coefficients, and a low human development index (HDI); group 2 (142 municipalities), with low DOT and FHS coverage; group 3 (36 municipalities), with medium DOT and FHS coverage and high tuberculosis incidence, high demand for anti-HIV testing, and treatment dropout; group 4 (186 municipalities) with lower HDI as compared to groups 2, 3, and 5, but high FHS coverage and the lowest numbers of anti-HIV testing, tuberculosis incidence, and DOT coverage; and group 5 (164 municipalities), with better social conditions as compared to the other groups, medium FHS coverage, and higher DOT coverage. Together, the first two components selected for the study-health service availability in terms of DOT coverage indicator and social inequality indicator-explained 76.96% of the variance. In municipalities with high DOT coverage there was evidence of better organized tuberculosis control services. CONCLUSIONS: Municipalities with the highest social inequality had FHS coverage. However, without DOT, FHS seem less efficient to control tuberculosis.

Tuberculose e iniquidade social em saúde: uma análise ecológica utilizando técnicas estatísticas multivariadas, São Paulo, Brasil / Tuberculosis and social inequity in health: an ecological study using multivariate statistical techniques, São Paulo, Brazil

OBJETIVO: Identificar os padrões dos municípios do estado de São Paulo quanto à relação da tuberculose com os indicadores de oferta e serviços de saúde, contexto e iniquidade social. MÉTODOS: Estudo ecológico que considerou os 645 municípios do estado de São Paulo e oito variáveis inseridas nas dimensões indicadores de oferta de serviços de saúde, contexto e iniquidade social. Nas análises, utilizaram-se as técnicas de agrupamento nível hierárquico, não hierárquico, de componentes principais e de geoprocessamento. RESULTADOS: A investigação mostrou cinco grupos de municípios: grupo 1 (117 municípios), com coberturas equivalentes de tratamento diretamente observado (TDO) e Estratégia Saúde da Família (ESF), coeficientes de incidência e de óbito elevados e baixo índice de desenvolvimento humano (IDH), grupo 2 (142 municípios), com baixa cobertura de TDO e ESF; grupo 3 (36 municípios), com cobertura mediana de ESF e TDO e elevados coeficientes de incidência de tuberculose, demanda do teste anti-HIV e abandono do tratamento; grupo 4 (186 municípios), com IDH abaixo dos grupos 2, 3 e 5, porém alta cobertura de ESF e os menores valores de testes anti-HIV, incidência de tuberculose e cobertura de TDO; grupo 5 (164 municípios), com condição social mais favorável do que os demais grupos, com coberturas de ESF em valores medianos e de TDO mais elevadas. As duas primeiras componentes selecionadas para o estudo - indicador de oferta de serviços de saúde em função da cobertura de TDO e indicador de iniquidade social - representaram juntas 76,96% da variância. Nos municípios com alta cobertura de TDO houve evidências de melhor organização dos serviços para o controle da tuberculose. CONCLUSÕES: Observou-se cobertura da ESF nos municípios com maior iniquidade. Porém, sem TDO, o resultado da ESF para controle da tuberculose parece não ser tão eficaz.

OBJECTIVE: To identify the patterns of São Paulo state municipalities, in Brazil, regarding the relationship between tuberculosis and indicators of health care services, health care service availability, context, and social inequality. METHODS: This ecological study covered all 645 municipalities of São Paulo and eight variables belonging to three dimensions: health care service availability, context, and social inequality. Data were analyzed using hierarchical and non-hierarchical clustering, principal components analysis, and geoprocessing. RESULTS: The analysis revealed five groups of municipalities: group 1 (117 municipalities), with similar directly observed treatment (DOT) and family health strategy (FHS) coverage, high tuberculosis incidence and death coefficients, and a low human development index (HDI); group 2 (142 municipalities), with low DOT and FHS coverage; group 3 (36 municipalities), with medium DOT and FHS coverage and high tuberculosis incidence, high demand for anti-HIV testing, and treatment dropout; group 4 (186 municipalities) with lower HDI as compared to groups 2, 3, and 5, but high FHS coverage and the lowest numbers of anti-HIV testing, tuberculosis incidence, and DOT coverage; and group 5 (164 municipalities), with better social conditions as compared to the other groups, medium FHS coverage, and higher DOT coverage. Together, the first two components selected for the study-health service availability in terms of DOT coverage indicator and social inequality indicator-explained 76.96% of the variance. In municipalities with high DOT coverage there was evidence of better organized tuberculosis control services. CONCLUSIONS: Municipalities with the highest social inequality had FHS coverage. However, without DOT, FHS seem less efficient to control tuberculosis.

[Long term psychosocial outcomes of congenital heart disease in adolescents and young adults].

OBJECTIVE: Congenital heart disease (CHD) is a chronic illness with a high frequency in the worldwide population, and is normally diagnosed at birth or in uterus. Because of better conditions in diagnosis and early medical and surgical treatment, patients have survival rates of 90% and go further and further in life, facing different challenges in life cycle. In this study, we tested the effects of different demographic, clinical and psychosocial variables on the perception of quality of life (QOL), on psychosocial adjustment (PSA) and psychiatric morbidity (PM) of adolescents and young adults with CHD. We aimed to evaluate QOL, PM and PSA of adolescents and young adults with CHD and to determine which variables (demographic, clinical, and psychosocial) play a role in buffering stress and promoting resilience and which ones have a detrimental effect. METHODS: The study enrolled 150 CHD patients (87 males and 63 females), 12 to 26 years (17.45±3.373 years). The participants were interviewed regarding social support, family educational style, self-image, demographic information and physical limitations. They responded to questions in a standardized psychiatric interview (SADS-L) and completed self-reports questionnaires for assessment of QOL (WHOQOL-BREF) and PSA (YSR/ASR). RESULTS: We found a 18.7% lifetime prevalence of psychopathology in our participants (25.4% in females and 13.8% in males). 57.1% had retentions in school (1.53±0.804 year). The perception of QOL of CHD patients is better compared to the Portuguese population in the social relationships, environmental, physical and general dimensions. However, it is worse in female CHD patients and patients with poor academic performance and social support as well as in patients with complex or cyanotic CHD, moderate-to-severe residual lesions and physical limitations, and undergoing surgery. All of these variables, except presence of cyanosis, are also associated to a worse PSA. CONCLUSIONS: Female patients and patients with poor academic performance and poor social support refer worse PSA and QOL.