Ventral prefrontal network response to alcohol in young adults with bipolar disorder: a within-subject randomized placebo-controlled alcohol administration study.

Bipolar disorder co-occurs with alcohol use disorder at a rate 3-5 times higher than the general population. We recently reported that individuals with bipolar disorder differ in the positive stimulating and anxiolytic effects of alcohol compared with healthy peers. This study used a randomized, placebo-controlled, cross-over, within-subject alcohol administration design to investigate neurobiological mechanisms within ventral prefrontal cortical (vPFC) systems that may underlie altered sensitivity to alcohol in bipolar disorder (NCT04063384). Forty-seven young adults (n = 23 with bipolar disorder, 64% women) completed clinical assessment and two beverage administration sessions (alcohol and placebo, counter-balanced). Participants were dosed to 0.08 g% breath alcohol concentration during the alcohol condition and completed measures of subjective response to alcohol and an emotional processing fMRI task during the ascending limb. Timing during the placebo condition mirrored the alcohol session. Acute alcohol was associated with reduced functional connectivity between the insula - subcallosal cingulate cortex, and increased connectivity between the left nucleus accumbens - ventromedial PFC in bipolar disorder, but with no change in functional connectivity between these regions in healthy peers. Alcohol-related increases in nucleus accumbens - ventromedial PFC functional connectivity was associated with greater positive stimulating effects of alcohol in bipolar disorder and heavier recent alcohol use. Results suggest vPFC brain systems respond differently to acute alcohol during emotional processing in young adults with bipolar disorder compared with healthy peers, and that vPFC system responses relate to the subjective experience of intoxication and recent alcohol use.

Subjective response to alcohol: Interactive effects of early life stress, parental risk for mood and substance use disorders, and drinking context.

Early life stress, specifically childhood maltreatment, and parental risk for mood and substance use disorders (SUDs) are associated with increased risk for alcohol use disorder (AUD). There is limited data on how these factors interact to contribute to alcohol-related outcomes. Prior work has suggested early life stress may increase sensitivity to psychostimulants and that subjective response to alcohol is heritable. It is unclear if early life stress alters sensitivity to alcohol and interacts with parental risk for mood/SUDs, which in turn may act as a risk factor for AUD. The current study uses within-subjects placebo-controlled alcohol administration methods to investigate the effects of childhood maltreatment on subjective response to alcohol in young adults with and without parental risk of mood/SUDs. Additionally, we explored interactions with drinking context (i.e., drinking in a bar vs. non-bar context). Within individuals with parental risk for mood/SUDs, there was a positive relation between total Childhood Trauma Questionnaire (CTQ) score and how drunk individuals reported feeling across both alcohol and placebo conditions (parental risk group-by-CTQ interaction p = .01; main effect of CTQ within individuals with parental risk for mood/SUDs p = .005). When exploring interactions with drinking context (bar vs. non-bar context), we observed a significant drinking context-by-parental risk-by-CTQ interaction (p = .03), with CTQ score positively associated with greater positive valence/positive arousal feelings in the parental risk group if they consumed their beverages in the bar context (p = .004) but not if they consumed their beverages in the non-bar context. Results suggest childhood maltreatment may contribute to variation in subjective response to the positive effects of alcohol-possibly mediated by alcohol cues and/or expectancies-in young adults with parental risk for mood/SUDs.

Subjective response to alcohol in young adults with bipolar disorder and recent alcohol use: a within-subject randomized placebo-controlled alcohol administration study.

Limited data exists on mechanisms contributing to elevated risk for alcohol use disorder (AUD) in bipolar disorder. Variation in subjective response to alcohol may relate to alcohol use and risk for AUD. This study used a randomized, placebo-controlled, cross-over, within-subjects design to investigate differences in subjective response to alcohol in 50 euthymic young adults (n = 24 with and n = 26 without bipolar disorder type I). Eighty-three percent of participants with bipolar disorder were medicated. Participants completed assessments of clinical history, alcohol expectancies, and recent alcohol use. Participants were dosed to a .08 g% breath alcohol concentration. The placebo condition occurred on a separate counter-balanced day. Subjective response to alcohol was investigated at similar time points during both conditions. Group, condition, and group-by-condition interactions were modeled, with condition and time of subjective response assessment as repeated within-subject variables, and subjective response to alcohol as the dependent variable. Greater stimulating effects and liking of alcohol were reported in people with bipolar disorder (group-by-condition interactions, p < .05) than healthy young adults. While young adults with bipolar disorder reported anticipating feeling less "mellow/relaxed" when drinking (p = .02), during both beverage conditions they reported feeling more "mellow/relaxed" (main effect of group, p = .006). Feeling more "mellow/relaxed" during the alcohol condition related to greater recent alcohol use in bipolar disorder (p = .001). Exploratory analyses suggested anticonvulsants and sedatives/antihistamines may relate to differences in subjective response to alcohol in bipolar disorder. Results suggest young adults with bipolar disorder may differ in alcohol expectancies and experience alcohol intoxication differently-with distinct relations between subjective response to alcohol and alcohol use-compared to healthy young adults.

Coping drinking motives, neural functional coupling during emotion processing, and alcohol use in young adults with bipolar disorder.

BACKGROUND: Rates of alcohol use disorders in individuals with bipolar disorder are 3 to 5 times greater than in the general population and exceed rates of alcohol use disorders reported in other affective and anxiety disorders. Despite this high rate of comorbidity, our understanding of the psychosocial and neural mechanisms that underlie the initiation of alcohol misuse in young adults with bipolar disorder remains limited. Prior work suggests that individuals with bipolar disorder may misuse alcohol as a coping mechanism, yet the neural correlates of coping drinking motives and associated alcohol use have not been previously investigated in this population. METHODS: Forty-eight young adults (22 bipolar disorder type I, 26 typically developing; 71% women; average age ± standard deviation = 22 ± 2 years) completed the Drinking Motives and Daily Drinking Questionnaires, and a Continuous Performance Functional magnetic resonance imaging (fMRI) Task with Emotional and Neutral Distracters. We calculated the relative difference in anterior cingulate cortex (ACC) functional coupling with the anterior insula and amygdala in response to emotional distracters compared with neutral stimuli and investigated the relations with coping drinking motives and alcohol use. RESULTS: Across all participants, coping drinking motives were associated with greater quantity of recent alcohol use. In individuals with bipolar disorder, greater ACC-anterior insula functional coupling was associated with greater coping drinking motives, and greater quantity and frequency of recent alcohol use. The relative difference in ACC-anterior insula functional coupling was not associated with coping drinking motives or alcohol use in the typically developing group. Greater ACC-anterior insula functional coupling in individuals with bipolar disorder was also associated with greater anxiety symptoms and recent perceived psychological stress. Exploratory analyses suggest that the relations between ACC-anterior insula functional coupling and coping drinking motives may be confounded by anticonvulsant use. CONCLUSION: Results suggest that a difference in ACC-anterior insula functional coupling during emotion processing may underlie alcohol use as a maladaptive coping mechanism in young adults with bipolar disorder.

A longitudinal examination of relations between competitive athletic participation, drinking norms, impulsivity, and sensation seeking and binge drinking throughout college.

OBJECTIVE: College athletes are a high-risk group for heavy drinking and related risky behaviors and consequences. However, most prior work examining drinking behavior in college athletes has been cross-sectional. Drinking norms predict drinking among athletes, but other potential risk factors, including personality traits have received limited attention. METHOD: Using data from a large sample (n = 2,245) of college students, we examined athletic participation, high-risk personality traits (i.e., impulsivity, sensation seeking), and perceptions of peer drinking behavior (descriptive and injunctive norms) as predictors of binge drinking from prior to college entry through 2 years postcollege. Negative binomial latent growth models were used to examine these predictors of patterns of drinking across the college years. RESULTS: Binge drinking increased through the first 3 years of college before leveling off and decreasing postcollege. Controlling for significant effects of sensation seeking and perceptions of peer attitudes and drinking behaviors, athletic participation at T1 was associated with greater binge drinking at matriculation and greater athletic participation was associated with greater risk across the college years. Normative perceptions and sensation seeking also predicted concurrent drinking in Year 4 of college and impulsivity emerged as an additional predictor. Sensation seeking emerged as a significant predictor of greater postcollege binge drinking. Athletic participation in Year 4 of college indicated no significant risk for greater binge drinking during Year 4 or following graduation. CONCLUSIONS: Early participation in competitive athletics was associated with risk for binge drinking, even when accounting for several social and personality factors. Future studies using momentary assessment may be fruitful for identifying within-subject pathways of risk, including athlete specific factors. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Alcohol Use and Prefrontal Cortex Volume Trajectories in Young Adults with Mood Disorders and Associated Clinical Outcomes.

(1) Background: Alcohol use in the course of mood disorders is associated with worse clinical outcomes. The mechanisms by which alcohol use alters the course of illness are unclear but may relate to prefrontal cortical (PFC) sensitivity to alcohol. We investigated associations between alcohol use and PFC structural trajectories in young adults with a mood disorder compared to typically developing peers. (2) Methods: 41 young adults (24 with a mood disorder, agemean = 21 ± 2 years) completed clinical evaluations, assessment of alcohol use, and two structural MRI scans approximately one year apart. Freesurfer was used to segment PFC regions of interest (ROIs) (anterior cingulate, orbitofrontal cortex, and frontal pole). Effects of group, alcohol use, time, and interactions among these variables on PFC ROIs at baseline and follow-up were modeled. Associations were examined between alcohol use and longitudinal changes in PFC ROIs with prospective mood. (3) Results: Greater alcohol use was prospectively associated with decreased frontal pole volume in participants with a mood disorder, but not typically developing comparison participants (time-by-group-by-alcohol interaction; p = 0.007); however, this interaction became a statistical trend in a sensitivity analysis excluding one outlier in terms of alcohol use. Greater alcohol use and a decrease in frontal pole volume related to longer duration of major depression during follow-up (p's < 0.05). (4) Conclusion: Preliminary findings support more research on alcohol use, PFC trajectories, and depression recurrence in young adults with a mood disorder including individuals with heavier drinking patterns.

Selection and socialization accounts of the relation between fraternity membership and sexual aggression.

OBJECTIVE: The current project aims to enhance our understanding of the well-established relation between fraternity membership and sexual aggression on college campuses. Most prior research has been cross-sectional and unable to distinguish selection and socialization accounts of the relation, and only one prior longitudinal study has simultaneously examined selection and socialization effects. METHOD: Fraternity membership, sexual aggression, binge drinking, sociosexual attitudes and behaviors, and perceived peer sexual aggression were assessed for 772 male participants (n = 116 fraternity members) in a longitudinal survey study from the summer prior to college through Year 2 of college. RESULTS: Longitudinal path analyses revealed three key findings. First, fraternity membership was prospectively correlated with sexual aggression in Years 1 and 2 of college (socialization effect), controlling for selection effects, when the two prospective paths were constrained to be equivalent. Second, more frequent binge drinking and sociosexual attitudes prior to college prospectively correlated with an increased likelihood of joining a fraternity (selection effect), and both selection variables indirectly correlated with future sexual aggression via fraternity membership. Third, fraternity membership was associated with increased binge drinking and perceived peer sexual aggression (socialization effects). CONCLUSIONS: These findings identify critical targets for the prevention of sexually aggressive behavior that are linked to fraternity membership: Binge drinking and sociosexual attitudes. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Childhood maltreatment, prefrontal-paralimbic gray matter volume, and substance use in young adults and interactions with risk for bipolar disorder.

Childhood maltreatment is associated with adverse effects on the brain, and an increased risk for psychopathology, including mood and substance use disorders. Individuals vary on the degree to which they exhibit neurobiological and clinical differences following maltreatment. Individuals with bipolar disorder exhibit greater magnitude of maltreatment-related prefrontal-paralimbic gray matter volume (GMV) deficits compared to typically developing individuals. It is unclear if greater structural differences stem from greater neural vulnerability to maltreatment in bipolar disorder, or if they relate to presence of other clinical features associated with childhood maltreatment, e.g., elevated prevalence of comorbid substance use disorders. To investigate this, we compared young adults with a family history of bipolar disorder (n = 21), but who did not fulfill diagnostic criteria for bipolar disorder, with typically developing young adults without a family history of bipolar disorder (n = 26). Participants completed structural neuroimaging, clinical and family history interviews, and assessment of childhood maltreatment and recent alcohol and cannabis use patterns. We examined relations between childhood maltreatment and prefrontal-paralimbic GMV by modeling main effects of maltreatment and family history group by maltreatment interactions on prefrontal-paralimbic GMV. We also examined relations between maltreatment and associated GMV changes with recent alcohol and cannabis use. Childhood maltreatment correlated with lower ventral, rostral and dorsolateral prefrontal and insular cortical GMV across all participants regardless of the presence or absence of familial history of bipolar disorder. However, exploratory analyses did reveal greater maltreatment-related GMV differences in individuals with prodromal symptoms of depression. Lower insula GMV was associated with greater frequency of cannabis use across all participants and greater quantity of alcohol use only in those with familial risk for bipolar disorder. Results suggest familial risk for bipolar disorder, and presumably genetic risk, may relate to outcomes following childhood maltreatment and should be considered in prevention/early intervention strategies.

Mediating Factors Explaining the Association Between Sexual Minority Status and Dating Violence.

Dating violence presents a serious threat for individual health and well-being. A growing body of literature suggests that starting in adolescence, individuals with sexual minority identities (e.g., individuals who identify as gay, lesbian, or bisexual) may be at an increased risk for dating violence compared with heterosexuals. Research has not, however, identified the mechanisms that explain this vulnerability. Using a diverse sample of young adults (n = 2,474), the current study explored how minority stress theory, revictimization theory, sex of sexual partners, and risky sexual behavior explained differences in dating violence between sexual minority and heterosexual young adults. Initial analyses suggested higher rates of dating violence among individuals who identified as bisexual, and individuals who identified as gay or lesbian when compared with heterosexuals, and further found that these associations failed to differ across gender. When mediating and control variables were included in the analyses, however, the association between both sexual minority identities and higher levels of dating violence became nonsignificant. Of particular interest was the role of discrimination, which mediated the association between bisexual identity and dating violence. Other factors, including sex and number of sexual partners, alcohol use, and childhood maltreatment, were associated with higher rates of dating violence but did not significantly explain vulnerability among sexual minority individuals compared with their heterosexual peers. These findings suggest the importance of minority stress theory in explaining vulnerability to dating violence victimization among bisexuals in particular, and generally support the importance of sexual-minority specific variables in understanding risk for dating violence within this vulnerable population.

The Differential Influence of Drinking, Sensation Seeking, and Impulsivity on the Perpetration of Unwanted Sexual Advances and Sexual Coercion.

There are startling rates of sexual coercion across college campuses, underscoring the importance of identifying risk factors and intervening early to prevent perpetration of these unwanted sexual events. The aim of this study was to examine the effects of impulsivity, sensation seeking, and alcohol use on the odds of perpetrating unwanted sexual advances (i.e., forced fondling, kissing, or petting) and sexual coercion (i.e., sexual intercourse through arguments, pressure, or physical force) during the subsequent 6 years. Male participants (N = 901) were part of a 6-year longitudinal study, which explored alcohol use and associated behavioral risks throughout emerging adulthood. Participants provided self-reported surveys across 6 years, starting the summer before their start of college. Using logistic regression models, these analyses examined the main effects and interactions of impulsivity, sensation seeking, and alcohol use, measured during the summer before the start of college, on the odds of perpetrating one or multiple instances of unwanted sexual advances and sexual coercion across the subsequent 6 years. Results indicated that higher levels of sensation seeking and heavier drinking on drinking days during high school contributed to greater odds of being a one-time perpetrator of unwanted sexual advances during the next 6 years. Conversely, impulsivity, but not alcohol use, was associated with greater risk of perpetrating multiple instances of both unwanted sexual advances and sexual coercion. Alcohol use did not significantly moderate the influence of personality on perpetration. These results underscore the importance of early intervention and using impulsivity and sensation seeking to tailor current prevention efforts to decrease the likelihood of sexual coercion perpetration during college.

Contextual influences on subjective alcohol response.

Prior research demonstrates contextual influences on drug responses in both animals and humans, although studies in humans typically focus on only one aspect of context (e.g., social) and examine a limited range of subjective experiences. The current study sought to address these limitations by examining the impact of both social and physical context on the full range of subjective alcohol effects. The sample included 448 young adult social drinkers (57% male, 66.5% White) randomly assigned to consume alcohol (target blood alcohol concentration of .08 g%) or placebo in 1 of 4 contexts (solitary lab, group lab, solitary bar, group bar). Results indicated that high arousal positive (HAP) effects of alcohol (e.g., talkative, lively) were stronger in nonbar relative to bar contexts and that low arousal positive (LAP) effects (e.g., relaxed, calm) were only present in the group lab context. There were also main effects of social context such that high arousal effects (both positive and negative) were stronger in group contexts, regardless of beverage condition. These findings highlight the importance of considering context when examining alcohol effects. Studies designed to isolate pharmacological HAP effects may benefit from a nonbar setting, and studies of LAP effects might be most effective in a simulated living room or home environment, although future studies are needed to directly address this possibility. Further, studies with an explicit focus on expectancies or that need strong control for expectancies might benefit from a group context, particularly when studying high arousal effects. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Subjective response to alcohol: Associated alcohol use and orbitofrontal gray matter volume in bipolar disorder.

BACKGROUND: Alcohol use disorders (AUDs) are highly prevalent in bipolar disorder, however the developmental etiology of this comorbidity remains unknown. Structural differences in the orbitofrontal cortex (OFC) have been linked to problematic drinking in bipolar disorder and typically developing youth, with evidence implicating variations in OFC in differential subjective response to alcohol in typical development. METHODS: Subjective response to alcohol, recent alcohol use, impulsivity, and variation in OFC gray matter volume were investigated in 48 emerging adults (24 with bipolar disorder, 24 typically developing). On average 1.5 years later, drinking patterns were reassessed and relations between subjective response and changes in alcohol use were explored. RESULTS: Groups did not differ in baseline alcohol use or subjective response. At baseline, decreased subjective response to alcohol was associated with increased alcohol use in both groups. Lower gray matter volume in medial OFC in bipolar disorder was associated with increased subjective response to alcohol, whereas lower gray matter volume in OFC in typically developing participants was associated with decreased subjective response to alcohol. Increase in alcohol use (baseline to follow-up) was associated with increased baseline subjective response to alcohol in bipolar disorder, and decreased baseline subjective response in the typically developing group. LIMITATIONS: Preliminary study with a small sample size. CONCLUSION: Underlying OFC biology may contribute to differences in alcohol sensitivity in bipolar disorder which may also relate to prospective changes in alcohol use patterns. Future studies are needed to examine how these factors prospectively relate to development of AUDs in bipolar disorder.

The Role of Relationship Changes in College Students' Heavy Episodic Drinking.

OBJECTIVE: The beginning of college is a period in which increased alcohol use often coincides with greater involvement in romantic relationships. Existing literature yields inconsistent findings regarding the influence of relationship types on drinking behavior, perhaps because these studies have not accounted for recent changes in the way college students engage in dating/sexual relationships. METHODS: The present study sought to address this issue using a longitudinal study design by examining the effects of both relationship type and sexual activity on heavy episodic drinking (HED) among 1,847 college students over the course of the first 3 semesters of college. RESULTS: Results indicated that the effects of relationship type depended on whether an individual was sexually active. Nondating but sexually active students reported rates of HED comparable to students who defined themselves as casual daters. Conversely, nondating students who were not sexually active reported drinking behavior similar to those involved in exclusive relationships. Further, transitions between low- and high-risk relationship/sexual activity types were associated with corresponding changes in HED. Transitioning into a high-risk relationship was associated with significant increases in levels of HED, whereas transitioning into a low-risk relationship was associated with significant decreases in HED. CONCLUSIONS: Together, results indicate that engaging in nonexclusive dating or casual sexual relationships may play an important role in the development of problematic patterns of alcohol use during the early college years. These findings have potentially important implications both for future research and for prevention and intervention efforts targeting high-risk college drinkers.

Relations among religiosity, age of self-identification as gay, lesbian, or bisexual, and alcohol use among college students.

Research indicates that lesbian, gay, and bisexual (LGB) youth are at increased risk for heavy drinking relative to their heterosexual peers. One possible contributing factor is that religiosity fails to provide the significant protection for LGB youth that it provides in general population samples. Although prior studies provide some support for this hypothesis, there is little research on the reasons that religiosity may fail to protect against heavy drinking among LGB youth. The current study addressed this question by examining relations among religiosity, age of self-identification as LGB, and alcohol use in a sample of 162 young adults self-identified as lesbian, gay, bisexual, or questioning. Age of self-identification was conceptualized as an indicator of stress or internal conflict between religious beliefs and self-identification. We hypothesized that higher levels of religiosity would be associated with a later age of identification as LGB, which, in turn, would contribute to heavier drinking. Path analyses conducted in Mplus provided support for this hypothesis, with higher levels of religiosity indirectly contributing to increased alcohol use through later age of self-identification. Whereas additional studies directly assessing stress associated with the self-identification process are needed, the results of this study suggest that religiosity may serve as a risk, rather than protective, factor among LGB youth. The development of religious support groups specifically for LGB youth may help these individuals reconcile their religious beliefs with their emerging sexual identities, thereby allowing them to derive some of the same benefits that heterosexual youth derive from religious beliefs and practices. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Female drinkers are more sensitive than male drinkers to alcohol-induced heart rate increase.

The present study examined the acute effect of alcohol and its cues on autonomic and cardiovascular physiology, as indexed by changes in heart rate (HR), in a relatively large sample of healthy young adult men and women. Participants (27-31 years old, final N = 145) were administered an alcoholic beverage (n = 88; 52 women) or a placebo beverage (n = 57; 35 women) in a simulated bar. Target breath alcohol concentration (BrAC) was .08 g%. HR was recorded while participants were seated alone during an initial baseline assessment in a lab room; seated with others during preparation and administration of 2 beverages in a simulated bar; and seated alone in the lab room at ascending, peak, and descending BrAC. HR increased over time for participants in both beverage groups during beverage preparation. During beverage consumption, HR decreased over time in those who drank placebo whereas HR increased over time in those who drank alcohol, increasing at a faster rate in women compared to men. HR remained elevated at the ascending, peak, and descending limb assessments only in participants who drank alcohol with HR increasing over time at ascending BrAC in the women but not men. Sex differences in HR under alcohol were not explained by sex differences in body mass index, BrAC, recent alcohol use, or subjective stimulation. Our findings suggest that women may be more sensitive to alcohol-induced increases in HR, especially in environments where alcohol cues are abundant. This may have implications for cardiovascular risks associated with alcohol. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Swiping right: Alcohol, online dating, and sexual hookups in postcollege women.

The development of online dating has created a cultural shift in how emerging adults approach dating. The present study examined retrospective and event-level associations between alcohol, online dating, and sexual hookups among a sample of single, postcollege women. Participants completed baseline and 24 electronic daily diary surveys on alcohol use, sexual behavior, and method for meeting their sexual partners. We examined the influence of alcohol on sexual hookups, and how method of meeting a partner, and location prior to the hookup influenced level of intoxication during a sexual hookup. There was a within-person effect of alcohol on likelihood of engaging in a sexual hookup whereby hookups were more likely on days when women reported higher levels of intoxication relative to their average drinking. Spending time at bar/party prior to a sexual hookup was associated with higher levels of intoxication prior to a sexual hookup relative to being at other locations. Measured in the daily diary surveys, meeting a sexual hookup partner online was associated with lower levels of intoxication during the hookup relative to when meeting at bars/parties, even when including location just prior to the hookup in the model. The baseline retrospective analyses also indicated that meeting a partner online was associated with drinking less frequently before a sexual hookup relative to meeting a partner at a bar/party. Interventions to address alcohol use, method for meeting a partner, and location prior to hookups could be effective in decreasing potential negative consequences of alcohol-related sexual behavior in emerging adult women. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Genetic risk for schizophrenia is associated with substance use in emerging adulthood: an event-level polygenic prediction model.

BACKGROUND: Emerging adulthood is a peak period of risk for alcohol and illicit drug use. Recent advances in psychiatric genetics suggest that the co-occurrence of substance use and psychopathology arises, in part, from a shared genetic etiology. We sought to extend this research by investigating the influence of genetic risk for schizophrenia on trajectories of four substance use behaviors as they occurred across emerging adulthood. METHOD: Young adult participants of non-Hispanic European descent provided DNA samples and completed daily reports of substance use for 1 month per year across 4 years (N = 30 085 observations of N = 342 participants). A schizophrenia polygenic score was included in two-level hierarchical linear models designed to test associations between genetic risk for schizophrenia, participant age, and four substance use phenotypes. RESULTS: Participants with a greater schizophrenia polygenic score experienced greater age-related increases in the likelihood of using substances across emerging adulthood (p < 0.005). Additionally, our results suggest that the polygenic score was positively associated with participants' overall likelihood to engage in illicit drug use but not alcohol-related substance use. CONCLUSIONS: This study used a novel combination of polygenic prediction and intensive longitudinal methods to characterize the influence of genetic risk for schizophrenia on patterns of age-related change in substance use across emerging adulthood. Results suggest that genetic risk for schizophrenia has developmentally specific effects on substance use behaviors in a non-clinical population of young adults.

A longitudinal event-level investigation of alcohol intoxication, alcohol-related blackouts, childhood sexual abuse, and sexual victimization among college students.

Sexual assault is a troubling epidemic that plagues college campuses across the United States, and is often proceeded by drinking by the perpetrator and/or victim. The goal of this study was to examine the effect of level of intoxication, history of alcohol-related blackouts, and childhood sexual abuse (CSA) on the likelihood of being a victim or perpetrator of coercive sexual activities. Participants (N = 2,244) were part of a 6-year longitudinal study which explored alcohol use and associated behavioral risks during college. A subsample (N = 1,423) completed 30 days of daily diary surveys across four years of college. Participants provided daily reports of their alcohol consumption, sexual coercion perpetration, and sexual coercion victimization. Using hierarchical linear models, results indicated that increases in daily estimated blood alcohol concentration (eBAC) were associated with a greater likelihood of being a victim and a perpetrator of sexual coercion. In addition, main effects of CSA and history of blackouts predicted a greater likelihood of being coerced into sexual activity, but blackouts were not associated with being a perpetrator. A significant interaction between blackouts and event-level eBAC indicated that individuals with a history of blackouts had a greater likelihood of sexual coercion victimization relative to those without prior blackouts. Finally, having a history of blackouts and CSA was predictive of a lower likelihood of being a perpetrator of sexual coercion at higher eBACs relative to those without a history of blackouts. Thus, prevention efforts should integrate the impact of blackouts and CSA on sexual coercion victimization and perpetration. (PsycINFO Database Record

GABRA2, alcohol, and illicit drug use: An event-level model of genetic risk for polysubstance use.

GABRA2, the gene encoding the α2 subunit of the GABAA receptor, potentially plays a role in the etiology of problematic drinking, as GABRA2 genotype has been associated with subjective response to alcohol and other alcohol-related reward processes. The GABRA2 gene has also been associated with illicit drug use, but the extent to which associations with drug use are independent of associations with alcohol use remains unclear, partly because most previous research has used a cross-sectional design that cannot discriminate comorbidity at the between-person level and co-occurrence within-persons. The present study used a daily monitoring method that assessed the effects of GABRA2 variation on substance use as it occurred in the natural environment during emerging adulthood. Non-Hispanic European participants provided DNA samples and completed daily reports of alcohol and drug use for 1 month per year across 4 years (N = 28,263 unique observations of N = 318 participants). GABRA2 variants were associated with illicit drug use in both sober and intoxicated conditions. Moreover, the effect of GABRA2 variation on drug use was moderated by an individual's degree of intoxication. These findings are consistent with recent genetic and neuroscience research, and they suggest GABRA2 variation influences drug-seeking behavior through both alcohol-related and alcohol-independent pathways. (PsycINFO Database Record