Automated screening for biological weapons in homeland defense.

Biological threat detection programs that collect air samples and monitor for large-scale release of biowarfare agents generate large numbers of samples that must be quickly and accurately screened for the presence of biological agents. An impediment to the rapid analysis of large numbers of environmental biological samples is that manual laboratory processes are time-consuming and require resources to maintain infrastructure, trained personnel, and adequate supplies of testing reagents. An ideal screening system would be capable of processing multiple samples rapidly, cost-effectively, and with minimal personnel. In the present study, we evaluated the Automated Biological Agent Testing System (ABATS) to explore the capability of automation to increase sample throughput, maximize system accuracy, and reduce the analysis costs associated with biological threat agent screening in environmental samples. This study demonstrates the utility of this concept and the potential of an automated system to address the growing environmental monitoring needs of the United States.

Automated biological agent testing systems.

The events of September 11, 2001 revealed a need for regular monitoring of infrastructure systems. Efficient aerosol collection systems are currently in place in a variety of settings in order to sample the immediate surroundings. However, the consequence of regular monitoring is an exponential increase in the number of samples requiring rapid analysis. Automated biological agent testing systems offer a solution by providing the ability to rapidly handle large numbers of samples with fewer personnel. In addition, automated testing also offers the advantage of increased consistency and accuracy compared with human systems.