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1.
N Engl J Med ; 369(7): 640-8, 2013 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-23944301

RESUMO

BACKGROUND: Recent advances have enabled delivery of high-intensity focused ultrasound through the intact human cranium with magnetic resonance imaging (MRI) guidance. This preliminary study investigates the use of transcranial MRI-guided focused ultrasound thalamotomy for the treatment of essential tremor. METHODS: From February 2011 through December 2011, in an open-label, uncontrolled study, we used transcranial MRI-guided focused ultrasound to target the unilateral ventral intermediate nucleus of the thalamus in 15 patients with severe, medication-refractory essential tremor. We recorded all safety data and measured the effectiveness of tremor suppression using the Clinical Rating Scale for Tremor to calculate the total score (ranging from 0 to 160), hand subscore (primary outcome, ranging from 0 to 32), and disability subscore (ranging from 0 to 32), with higher scores indicating worse tremor. We assessed the patients' perceptions of treatment efficacy with the Quality of Life in Essential Tremor Questionnaire (ranging from 0 to 100%, with higher scores indicating greater perceived disability). RESULTS: Thermal ablation of the thalamic target occurred in all patients. Adverse effects of the procedure included transient sensory, cerebellar, motor, and speech abnormalities, with persistent paresthesias in four patients. Scores for hand tremor improved from 20.4 at baseline to 5.2 at 12 months (P=0.001). Total tremor scores improved from 54.9 to 24.3 (P=0.001). Disability scores improved from 18.2 to 2.8 (P=0.001). Quality-of-life scores improved from 37% to 11% (P=0.001). CONCLUSIONS: In this pilot study, essential tremor improved in 15 patients treated with MRI-guided focused ultrasound thalamotomy. Large, randomized, controlled trials will be required to assess the procedure's efficacy and safety. (Funded by the Focused Ultrasound Surgery Foundation; ClinicalTrials.gov number, NCT01304758.).


Assuntos
Tremor Essencial/terapia , Técnicas Estereotáxicas , Terapia por Ultrassom , Núcleos Ventrais do Tálamo , Idoso , Mapeamento Encefálico , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Terapia por Ultrassom/efeitos adversos , Terapia por Ultrassom/métodos , Núcleos Ventrais do Tálamo/patologia
2.
J Neurosurg ; 119(2): 307-17, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-23746105

RESUMO

OBJECT: The purpose of this study was to use MRI and histology to compare stereotactic lesioning modalities in a large brain model of thalamotomy. METHODS: A unilateral thalamotomy was performed in piglets utilizing one of 3 stereotactic lesioning modalities: focused ultrasound (FUS), radiofrequency, and radiosurgery. Standard clinical lesioning parameters were used for each treatment; and clinical, MRI, and histological assessments were made at early (< 72 hours), subacute (1 week), and later (1-3 months) time intervals. RESULTS: Histological and MRI assessment showed similar development for FUS and radiofrequency lesions. T2-weighted MRI revealed 3 concentric lesional zones at 48 hours with resolution of perilesional edema by 1 week. Acute ischemic infarction with macrophage infiltration was most prominent at 72 hours, with subsequent resolution of the inflammatory reaction and coalescence of the necrotic zone. There was no apparent difference in ischemic penumbra or "sharpness" between FUS or radiofrequency lesions. The radiosurgery lesions presented differently, with latent effects, less circumscribed lesions at 3 months, and apparent histological changes seen in white matter beyond the thalamic target. Additionally, thermal and radiation lesioning gradients were compared with modeling by dose to examine the theoretical penumbra. CONCLUSIONS: In swine thalamus, FUS and radiosurgery lesions evolve similarly as determined by MRI, histological examination, and theoretical modeling. Radiosurgery produces lesions with more delayed effects and seemed to result in changes in the white matter beyond the thalamic target.


Assuntos
Tratamento por Radiofrequência Pulsada/métodos , Radiocirurgia/métodos , Tálamo/cirurgia , Ultrassonografia/métodos , Animais , Feminino , Imageamento por Ressonância Magnética , Suínos , Tálamo/patologia
3.
Stereotact Funct Neurosurg ; 89(6): 357-64, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-22104373

RESUMO

BACKGROUND/AIMS: Subthalamic nucleus (STN) deep brain stimulation (DBS) is an effective therapy for Parkinson's disease (PD). This study investigates whether improvement for particular PD symptoms varies differentially with respect to stimulation location in the STN. METHODS: Ten PD patients treated with bilateral STN DBS were enrolled in the study. Each electrode contact was stimulated independently to assess for changes in tremor, bradykinesia, and gait. Electrode contacts were localized via MRI. A novel iterative volumetric analysis was used to search the contact space for stimulation regions corresponding to alleviation of specific symptoms. RESULTS: Tremor was best controlled with DBS applied to the more dorsal, anterior, and medial areas of the contact space. Improvement in bradykinesia was seen largely within the middle of the contact space. Gait improvement was observed with ventral contacts, likely bordering the ventral boundaries of the STN. CONCLUSION: The iterative volumetric analysis is a valuable tool in identifying anatomic regions responsive to DBS across a subject population treated for PD. In the subjects tested, overlapping efficacy for all symptoms was observed in the region of the STN, but anatomic variances in the responsiveness for tremor, bradykinesia, and gait were found.


Assuntos
Estimulação Encefálica Profunda/métodos , Transtornos Neurológicos da Marcha/terapia , Hipocinesia/terapia , Doença de Parkinson/terapia , Núcleo Subtalâmico/cirurgia , Tremor/terapia , Idoso , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
4.
Brain ; 133(Pt 12): 3611-24, 2010 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-20861152

RESUMO

Past studies show beneficial as well as detrimental effects of subthalamic nucleus deep-brain stimulation on impulsive behaviour. We address this paradox by investigating individuals with Parkinson's disease treated with subthalamic nucleus stimulation (n = 17) and healthy controls without Parkinson's disease (n = 17) on performance in a Simon task. In this reaction time task, conflict between premature response impulses and goal-directed action selection is manipulated. We applied distributional analytic methods to separate the strength of the initial response impulse from the proficiency of inhibitory control engaged subsequently to suppress the impulse. Patients with Parkinson's disease were tested when stimulation was either turned on or off. Mean conflict interference effects did not differ between controls and patients, or within patients when stimulation was on versus off. In contrast, distributional analyses revealed two dissociable effects of subthalamic nucleus stimulation. Fast response errors indicated that stimulation increased impulsive, premature responding in high conflict situations. Later in the reaction process, however, stimulation improved the proficiency with which inhibitory control was engaged to suppress these impulses selectively, thereby facilitating selection of the correct action. This temporal dissociation supports a conceptual framework for resolving past paradoxical findings and further highlights that dynamic aspects of impulse and inhibitory control underlying goal-directed behaviour rely in part on neural circuitry inclusive of the subthalamic nucleus.


Assuntos
Estimulação Encefálica Profunda/efeitos adversos , Comportamento Impulsivo/psicologia , Doença de Parkinson/psicologia , Núcleo Subtalâmico/fisiologia , Idoso , Cognição/fisiologia , Feminino , Humanos , Comportamento Impulsivo/etiologia , Inibição Psicológica , Masculino , Pessoa de Meia-Idade , Doença de Parkinson/terapia , Córtex Pré-Frontal/fisiologia , Desempenho Psicomotor/fisiologia , Tempo de Reação/fisiologia
5.
J Neurosurg ; 110(2): 201-7, 2009 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-18821828

RESUMO

OBJECT: The authors analyzed deep brain stimulation electrode trajectories on MR images to identify risks of cerebrovascular complications associated with the number of electrode insertions, traversal of a sulcus, and penetration of the ventricle. METHODS: Pre- and postoperative MR volumes were fused to determine the proximity of electrodes to a sulcus or ventricle and whether there were cortical, subcortical, or intraventricular complications. Complications were further classified as hemorrhagic or nonhemorrhagic and symptomatic or asymptomatic. The authors examined 258 electrode implantation for deep brain stimulation. There were 4 symptomatic events (1.6% incidence): 3 hemorrhagic and 1 nonhemorrhagic, all within the cortex. Asymptomatic events included cortical hemorrhage in 1 patient, nonhemorrhagic cortical changes in 6, pallidal hemorrhage in 1, thalamic infarction in 1, and intraventricular hemorrhage (IVH) in 5 patients. RESULTS: Proximity to a sulcus was a significant risk factor for hemorrhagic and nonhemorrhagic cortical complications (p = 0.001). There was a complication rate of 10.1% within the trajectories penetrating or adjacent to a sulcus, and a 0.7% rate with trajectories clearly positioned within the gyrus. Asymptomatic IVH was observed in 5% of ventricular penetrations. A history of hypertension was a risk factor for cortical hemorrhage (p = 0.019), but not for cortical ischemic/edematous events (p = 0.605). The number of electrode penetrations did not differ between patients with and without complications (p = 0.868), and the sequence of electrode insertions was not a risk factor in bilateral surgeries. CONCLUSIONS: Symptomatic cortical complications occur when electrodes traverse close to a sulcus. Asymptomatic IVH occurs infrequently with ventricular penetration. Despite intraoperative efforts to avoid cortical sulci, a higher than expected incidence of electrode proximity to the sulci was identified on careful postoperative trajectory analysis. This finding emphasizes the importance of assiduously planning trajectories and reviewing cases with thorough MR analysis.


Assuntos
Córtex Cerebral/lesões , Hemorragia Cerebral Traumática/patologia , Ventrículos Cerebrais/lesões , Estimulação Encefálica Profunda/instrumentação , Distonia/terapia , Eletrodos/efeitos adversos , Traumatismos Cranianos Penetrantes/patologia , Processamento de Imagem Assistida por Computador , Imageamento por Ressonância Magnética , Doença de Parkinson/terapia , Técnicas Estereotáxicas/instrumentação , Tremor/terapia , Anticoagulantes/administração & dosagem , Anticoagulantes/efeitos adversos , Aspirina/administração & dosagem , Aspirina/efeitos adversos , Córtex Cerebral/patologia , Ventrículos Cerebrais/patologia , Estimulação Encefálica Profunda/efeitos adversos , Dominância Cerebral/fisiologia , Distonia/diagnóstico , Humanos , Microeletrodos/efeitos adversos , Doença de Parkinson/diagnóstico , Pré-Medicação , Estudos Retrospectivos , Fatores de Risco , Técnicas Estereotáxicas/efeitos adversos , Tremor/diagnóstico
6.
Mov Disord ; 24(2): 224-30, 2009 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-18951537

RESUMO

The activities of daily living (ADL) subscore of the Unified Parkinson's Disease Rating Scale (UPDRS) captures the impact of Parkinson's disease (PD) on daily function and may be less affected than other subsections by variability associated with drug cycle and motor fluctuations. We examined UPDRS mentation, ADL and motor subscores in 888 patients with idiopathic PD. Multiple linear regression analyses determined the association between disease duration and UPDRS subscores as a function of medication status at examination and in a subset of patients with multiple examinations. Independent of medication status and across cross-sectional and longitudinal analyses, ADL subscores showed a stronger and more stable association with disease duration than other UPDRS subscores after adjusting for age of disease onset. The association between disease duration and the motor subscore depended on medication status. The strong association between ADL subscore and disease duration in PD suggests that this measure may serve as a better marker of disease progression than signs and symptoms assessed in other UPDRS sections.


Assuntos
Atividades Cotidianas , Doença de Parkinson/fisiopatologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Antiparkinsonianos/uso terapêutico , Estudos Transversais , Progressão da Doença , Feminino , Seguimentos , Humanos , Levodopa/uso terapêutico , Masculino , Pessoa de Meia-Idade , Doença de Parkinson/tratamento farmacológico , Desempenho Psicomotor , Resultado do Tratamento
7.
Mov Disord ; 23(9): 1317-20, 2008 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-18442130

RESUMO

Stereotactic neurosurgeons hesitate to employ sedation in cases requiring microelectrode recording (MER). We report our experience with dexmedetomidine during MER of subthalamic nucleus (STN). Eleven Parkinsonian patients received dexmedetomidine during deep brain stimulation surgery. Seven received continuous IV infusions during MER in the STN. The bispectral index (BIS) was used to estimate the level of consciousness. The quality of MER was evaluated as a function of BIS, clinical arousal, and dexmedetomidine dose. MER during wakefulness (BIS > 80; 0.1 to 0.4 mcg/kg/hr dexmedetomidine) was similar to the unmedicated state. Subthalamic MER was reduced when the patient was asleep or unarousable (BIS < 80). Anxiolysis persisted for hours. Arousal affects STN neurons. Dexmedetomidine "cooperative sedation," from which the patient is easily aroused, provides interpretable STN MER and prolonged anxiolysis. We suggest dexmedetomidine infusions without a loading dose, a relatively low infusion rate, and discontinuation after completion of the bur holes.


Assuntos
Analgésicos não Narcóticos/farmacologia , Nível de Alerta/fisiologia , Dexmedetomidina/farmacologia , Neurônios/efeitos dos fármacos , Transtornos Parkinsonianos/terapia , Núcleo Subtalâmico/efeitos dos fármacos , Potenciais de Ação/efeitos dos fármacos , Estimulação Encefálica Profunda/métodos , Humanos , Microeletrodos , Estudos Retrospectivos , Núcleo Subtalâmico/citologia
8.
J Neurosurg ; 107(5): 983-8, 2007 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-17977271

RESUMO

OBJECT: The success of stereotactic surgery depends upon accuracy. Tissue deformation, or brain shift, can result in clinically significant errors. The authors measured cortical and subcortical brain shift during stereotactic surgery and assessed several variables that may affect it. METHODS: Preoperative and postoperative magnetic resonance imaging volumes were fused and 3D vectors of deviation were calculated for the anterior commissure (AC), posterior commissure (PC), and frontal cortex. Potential preoperative (age, diagnosis, and ventricular volume), intraoperative (stereotactic target, penetration of ventricles, and duration of surgery), and postoperative (volume of pneumocephalus) variables were analyzed and correlated with cortical (frontal cortex) and subcortical (AC, PC) deviations. RESULTS: Of 66 cases, nine showed a shift of the AC by more than 1.5 mm, and five by more than 2.0 mm. The largest AC shift was 5.67 mm. Deviation in the x, y, and z dimensions for each case was determined, and most of the cortical and subcortical shift occurred in the posterior direction. The mean 3D vector deviations for frontal cortex, AC, and PC were 3.5 +/- 2.0, 1.0 +/- 0.8, and 0.7 +/- 0.5 mm, respectively. The mean change in AC-PC length was -0.2 +/- -0.9 mm (range -4.28 to 1.66 mm). The volume of postoperative pneumocephalus, assumed to represent cerebrospinal fluid (CSF) loss, was significantly correlated with shift of the frontal cortex (r = 0.640, 64 degrees of freedom, p < 0.001) and even more strongly with shift of the AC (r = 0.754, p < 0.001). No other factors were significantly correlated with AC shift. Interestingly, penetration of the ventricles during electrode insertion, whether unilateral or bilateral, did not affect volume of pneumocephalus. CONCLUSIONS: Cortical and subcortical brain shift occurs during stereotactic surgery as a direct function of the volume of pneumocephalus, which probably reflects the volume of CSF that is lost. Clinically significant shifts appear to be uncommon, but stereotactic surgeons should be vigilant in preventing CSF loss.


Assuntos
Encéfalo/fisiologia , Córtex Cerebral/fisiologia , Técnicas Estereotáxicas , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Feminino , Humanos , Imageamento Tridimensional , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Pneumocefalia , Estudos Retrospectivos
9.
J Neurosurg ; 107(5): 998-1003, 2007 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-17977273

RESUMO

OBJECT: Intracranial hemorrhage (ICH) is the most significant complication associated with the placement of stereotactic intracerebral electrodes. Previous reports have suggested that hypertension and the use of microelectrode recording (MER) are risk factors for cerebral hemorrhage. The authors evaluated the incidence of symptomatic ICH in a large cohort of patients with various diseases treated with stereotactic electrode placement. They examined the effect of comorbidities on the risk of ICH and independently assessed the risks associated with age, sex, use of MER, diagnosis, target location, hypertension, and previous use of anticoagulant medications. The authors also evaluated the effect of hemorrhage on length of hospital stay and discharge disposition. METHODS: Between 1991 and 2005, 567 electrodes were placed by two neurosurgeons during 337 procedures in 259 patients. Deep brain stimulation (DBS) was performed in 167 procedures, radiofrequency lesioning (RFL) of subcortical structures in 74, and depth electrodes were used in 96 procedures in patients with epilepsy. Electrodes were grouped according to target, patient diagnosis, use of MER, patient history of hypertension, and patient prior use of anticoagulant medication (stopped 10 days before surgery). The Charlson Comorbidity Index (CCI) was used to evaluate the effect of comorbidities. The CCI score, patient age, length of hospital stay, and discharge status were continuous variables. Symptomatic hemorrhages were grouped as transient or leading to permanent neurological deficits. RESULTS: The risk of hemorrhage leading to permanent neurological deficits in this study was 0.7%, and the risk of symptomatic hemorrhage was 1.2%. A patient history of hypertension was the most significant factor associated with hemorrhage (p = 0.007). Older age, male sex, and a diagnosis of Parkinson disease (PD) were also significantly associated with hemorrhage (p = 0.01, 0.04, 0.007, respectively). High CCI scores, specific target locations, and prior use of anticoagulant therapy were not associated with an increased risk of hemorrhage. The use of MER was not found to be correlated with an increased hemorrhage rate (p = 0.34); however, the number of hemorrhages in the patients who underwent DBS was insufficient to draw definitive conclusions. The mean length of stay for the DBS, RFL, and depth electrode patient groups was 2.9, 2.6, and 11.0 days, respectively. For patients who received DBS and RFL, the mean duration of hospitalization in cases of symptomatic hemorrhage was 8.2 days compared with 2.7 days in those without hemorrhaging (p < 0.0001). Three of the seven patients with symptomatic hemorrhages were discharged home. CONCLUSIONS: The placement of stereotactic electrodes is generally safe, with a symptomatic hemorrhage rate of 1.2%, and a 0.7% rate of permanent neurological deficit. Consistent with prior reports, this study confirms that hypertension is a significant risk factor for hemorrhage. Age, male sex, and diagnosis of PD were also significant risk factors. Patients with symptomatic hemorrhage had longer hospital stays and were less likely to be discharged home.


Assuntos
Hemorragia Cerebral/etiologia , Eletrodos Implantados/efeitos adversos , Técnicas Estereotáxicas/efeitos adversos , Adulto , Idoso , Anticoagulantes/efeitos adversos , Estimulação Encefálica Profunda , Epilepsia/cirurgia , Feminino , Humanos , Hipertensão/complicações , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Fatores de Risco
10.
J Clin Sleep Med ; 3(1): 58-9, 2007 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-17557455

RESUMO

Stereotactic surgery with lesioning or deep brain stimulation directed to the ventralis intermedius nucleus of the thalamus is a well-recognized treatment for medically intractable tremor. A patient developed the rare complication of severe insomnia, easy awakening, and lack of slow-wave sleep after thalamotomy/deep brain stimulation implantation. This complication underscores the role of thalamic regulation on initiation and maintenance of sleep.


Assuntos
Núcleos da Linha Média do Tálamo/anatomia & histologia , Núcleos da Linha Média do Tálamo/cirurgia , Complicações Pós-Operatórias , Distúrbios do Início e da Manutenção do Sono/etiologia , Tremor/fisiopatologia , Tremor/cirurgia , Núcleos Ventrais do Tálamo/anatomia & histologia , Núcleos Ventrais do Tálamo/cirurgia , Doença Aguda , Idoso , Humanos , Imageamento por Ressonância Magnética , Masculino , Procedimentos Neurocirúrgicos/métodos , Polissonografia , Distúrbios do Início e da Manutenção do Sono/diagnóstico , Fases do Sono/fisiologia , Tremor/diagnóstico
11.
Neurology ; 66(2): 268-70, 2006 Jan 24.
Artigo em Inglês | MEDLINE | ID: mdl-16434672

RESUMO

As the population of patients treated with deep brain stimulation (DBS) grows and the patients age, more will require routine or emergent electrophysiologic tests. DBS artifact may render these uninterpretable, whereas stopping DBS may release symptoms that confound evaluation. The authors find that monopolar, but not bipolar, stimulation produces significant artifact during EKG, EEG, and polysomnography.


Assuntos
Estimulação Encefálica Profunda/métodos , Eletrocardiografia , Eletroencefalografia , Doença de Parkinson/terapia , Polissonografia , Tremor/terapia , Idoso , Artefatos , Humanos , Masculino , Doença de Parkinson/fisiopatologia , Fases do Sono , Tremor/fisiopatologia
12.
Respir Physiol Neurobiol ; 151(1): 44-60, 2006 Mar 28.
Artigo em Inglês | MEDLINE | ID: mdl-15993658

RESUMO

We hypothesized that neural processes mediating deficient sensory and autonomic regulatory mechanisms in obstructive sleep apnea (OSA) would be revealed by responses to inspiratory loading in brain regions regulating sensory and motor control. Functional magnetic resonance imaging (fMRI) signals and physiologic changes were assessed during baseline and inspiratory loading in 7 OSA patients and 11 controls, all male and medication-free. Heart rate increases to inspiratory loading began earlier and load pressures were achieved later in OSA patients. Comparable fMRI changes emerged in multiple brain regions in both groups, including limbic, cerebellar, midbrain, and primary motor cortex. However, in OSA subjects, altered signals appeared in primary sensory thalamus and sensory cortex, supplementary motor cortex, cerebellar cortex and deep nuclei, cingulate, medial temporal, and insular cortices, right hippocampus, and midbrain. Signal delays occurred in basal ganglia. We conclude that areas mediating sensory and autonomic processes, and motor timing, are affected in OSA; many of these areas overlap regions of previously demonstrated gray matter loss.


Assuntos
Encéfalo/irrigação sanguínea , Encéfalo/fisiopatologia , Inalação/fisiologia , Apneia Obstrutiva do Sono/fisiopatologia , Adulto , Pressão Sanguínea/fisiologia , Mapeamento Encefálico , Análise por Conglomerados , Eletroencefalografia , Frequência Cardíaca/fisiologia , Humanos , Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Oxigênio/sangue , Fatores de Tempo
13.
J Appl Physiol (1985) ; 94(4): 1583-95, 2003 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-12514164

RESUMO

Obstructive sleep apnea (OSA) patients exhibit altered sympathetic outflow, which may reveal mechanisms underlying the syndrome. We used functional MRI (fMRI) in 16 control and 10 OSA subjects who were free of cardiovascular or mood-altering drugs to examine neural responses to a forehead cold pressor challenge, which elicits respiratory slowing, bradycardia, and enhanced sympathetic outflow. The magnitude of cold-induced bradycardia was smaller, and respiratory slowing showed greater intersubject variability and reached a nadir later in OSA patients. Both groups showed similar signal changes to cold stimulation in multiple brain sites. However, signal increases emerged in OSA over controls in anterior and posterior cingulate and cerebellar and frontal cortex, whereas signals markedly declined in the ventral thalamus, hippocampus, and insula rather than rising as in controls. Anomalous responses often paralleled changes in breathing and heart rate. Medullary, midbrain areas and lentiform and cerebellar dentate nuclei also showed lower signals in OSA cases. Cold pressor physiological responses are modified in OSA and may result from both diminished and exaggerated responses in multiple brain structures.


Assuntos
Pressão Sanguínea , Encéfalo/fisiopatologia , Temperatura Baixa , Imageamento por Ressonância Magnética , Síndromes da Apneia do Sono/diagnóstico , Síndromes da Apneia do Sono/fisiopatologia , Adulto , Estudos de Casos e Controles , Análise por Conglomerados , Frequência Cardíaca , Humanos , Masculino , Pessoa de Meia-Idade , Mecânica Respiratória
14.
J Appl Physiol (1985) ; 94(3): 1063-74, 2003 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-12433858

RESUMO

The repetitive upper airway muscle atonic episodes and cardiovascular sequelae of obstructive sleep apnea (OSA) suggest dysfunction of specific neural sites that integrate afferent airway signals with autonomic and somatic outflow. We determined neural responses to the Valsalva maneuver by using functional magnetic resonance imaging. Images were collected during a baseline and three Valsalva maneuvers in 8 drug-free OSA patients and 15 controls. Multiple cortical, midbrain, pontine, and medullary regions in both groups showed intensity changes correlated to airway pressure. In OSA subjects, the left inferior parietal cortex, superior temporal gyrus, posterior insular cortex, cerebellar cortex, fastigial nucleus, and hippocampus showed attenuated signal changes compared with controls. Enhanced responses emerged in the left lateral precentral gyrus, left anterior cingulate, and superior frontal cortex of OSA patients. The anterior cingulate, cerebellar cortex, and posterior insula exhibited altered response timing patterns between control and OSA subjects. The response patterns in OSA subjects suggest deficits in particular neural pathways that normally mediate the Valsalva maneuver and compensatory actions in other structures.


Assuntos
Sistema Nervoso Autônomo/fisiopatologia , Apneia Obstrutiva do Sono/fisiopatologia , Manobra de Valsalva/fisiologia , Adulto , Resistência das Vias Respiratórias/fisiologia , Pressão Sanguínea/fisiologia , Encéfalo/fisiopatologia , Análise por Conglomerados , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Mecânica Respiratória
15.
J Neurophysiol ; 88(6): 3477-86, 2002 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-12466462

RESUMO

The Valsalva maneuver, a test frequently used to evaluate autonomic function, recruits discrete neural sites. The time courses of neural recruitment relative to accompanying cardiovascular and breathing patterns are unknown. We examined functional magnetic resonance imaging signal changes within the brain to repeated Valsalva maneuvers and correlated these changes with physiological trends. In 12 healthy subjects (age, 30-58 yr), a series of 25 volumes (20 gradient echo echo-planar image slices per volume) was collected using a 1.5-Tesla scanner during a 60-s baseline and 90-s challenge period consisting of three Valsalva maneuvers. Regions of interest were examined for signal intensity changes over baseline and challenge conditions in cardiorespiratory-related regions. In addition, whole brain correlations between signal intensity and heart rate and airway load pressure were performed on a voxel-by-voxel basis. Significant signal changes, correlated with the time course of load pressure and heart rate, emerged within multiple areas, including the amygdala and hippocampus, insular and lateral frontal cortices, dorsal pons, dorsal medulla, lentiform nucleus, and fastigial and dentate nuclei of the cerebellum. Signal intensities peaked early in the Valsalva maneuver within the hippocampus and amygdala, later within the dorsal medulla, pons and midbrain, and deep cerebellar nuclei, and last within the lentiform nuclei and the lateral prefrontal cortex. The ventral pontine signals increased during the challenge, but not in a fashion correlated to load pressure or heart rate. Sites showing little or no correlation included the vermis and medial prefrontal cortex. These data suggest an initiating component arising in rostral brain areas, a later contribution from cerebellar nuclei, basal ganglia, and lateral prefrontal cortex, and a role for the ventral pons in mediating longer term processes.


Assuntos
Tronco Encefálico/fisiologia , Encéfalo/fisiologia , Cerebelo/fisiologia , Imageamento por Ressonância Magnética , Manobra de Valsalva/fisiologia , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Tempo
16.
Am J Respir Crit Care Med ; 166(10): 1382-7, 2002 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-12421746

RESUMO

Obstructive sleep apnea (OSA) is characterized by repeated occurrences of hypoxic, hypercapnic, and transient blood pressure elevation episodes that may damage or alter neural structures. Underdeveloped structures or pre-existing damage in brain areas may also contribute to the genesis of the syndrome. Brain morphology in 21 patients with OSA and in 21 control subjects was assessed using high-resolution T1-weighted magnetic resonance imaging. Three-dimensional brain images were obtained with voxels of approximately 1 mm3. Images were spatially normalized and segmented into gray matter, white matter, and cerebrospinal fluid. For each segment, regional volumetric differences were determined relative to age, handedness, and group (patients with OSA versus control subjects), using voxel-based morphometry, with OSA effects weighted by disease severity. A significant age effect on total gray matter was found in control subjects but not in patients with OSA. Diminished regional and often unilateral gray matter loss was apparent in multiple sites of the brain in patients with OSA, including the frontal and parietal cortex, temporal lobe, anterior cingulate, hippocampus, and cerebellum. Unilateral loss in well-perfused structures suggests onset of neural deficits early in the OSA syndrome. The gray matter loss occurs within sites involved in motor regulation of the upper airway as well as in areas contributing to cognitive function.


Assuntos
Encéfalo/patologia , Apneia Obstrutiva do Sono/patologia , Adulto , Fatores Etários , Idoso , Líquido Cefalorraquidiano/química , Líquido Cefalorraquidiano/metabolismo , Humanos , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença
17.
J Appl Physiol (1985) ; 92(1): 331-42, 2002 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-11744676

RESUMO

We examined the sequence of neural responses to the hypotension, bradycardia, and apnea evoked by intravenous administration of 5-hydroxytryptamine (serotonin). Functional magnetic resonance imaging signal changes were assessed in nine isoflurane-anesthetized cats during baseline and after a bolus intravenous low dose (10 microg/kg) or high dose (20-30 microg/kg) of 5-hydroxytryptamine. In all cats, high-dose challenges elicited rapid-onset, transient signal declines in the intermediate portion of the solitary tract nucleus, caudal midline and caudal and rostral ventrolateral medulla, and fastigial nucleus of the cerebellum. Slightly delayed phasic declines appeared in the dentate and interpositus nuclei and dorsolateral pons. Late-developing responses also emerged in the solitary tract nucleus, parapyramidal region, periaqueductal gray, spinal trigeminal nucleus, inferior olivary nucleus, cerebellar vermis, and fastigial nucleus. Amygdala and hypothalamic sites showed delayed and prolonged signal increases. Intravenous serotonin infusion recruits cerebellar, amygdala, and hypothalamic sites in addition to classic brain stem cardiopulmonary areas and exhibits site-specific temporal patterns.


Assuntos
Encéfalo/efeitos dos fármacos , Neurônios/efeitos dos fármacos , Serotonina/farmacologia , Animais , Pressão Sanguínea/efeitos dos fármacos , Encéfalo/anatomia & histologia , Sistema Cardiovascular/inervação , Gatos , Imagem Ecoplanar , Eletrocardiografia , Feminino , Frequência Cardíaca/efeitos dos fármacos , Processamento de Imagem Assistida por Computador , Injeções Intravenosas , Pulmão/inervação , Imageamento por Ressonância Magnética , Masculino , Neurônios Aferentes/efeitos dos fármacos , Mecânica Respiratória/efeitos dos fármacos , Serotonina/administração & dosagem , Fatores de Tempo
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