RESUMO
We identified 4316 unselected incident cases of early-onset breast cancers (<51 ears of age at diagnosis) in 18 Polish hospitals between 1996 and 2003. We were able to obtain a blood sample for DNA analysis from 3472 of these (80.4%). All cases were tested for the presence of three founder mutations in BRCA1. The proportion of cases with a BRCA1 mutation was 5.7%. The hereditary proportions were higher than this for women with breast cancer diagnosed before age 40 (9%), for women with cancer of medullary or atypical medullary histology (28%), for those with bilateral cancer (29%) or with a family history of breast or ovarian cancer (13%). It is reasonable to offer genetic testing to women with early-onset breast cancer in Poland.
Assuntos
Proteína BRCA1/biossíntese , Neoplasias da Mama/epidemiologia , Neoplasias da Mama/genética , Regulação Neoplásica da Expressão Gênica , Genes BRCA1 , Predisposição Genética para Doença , Mutação , Adulto , Neoplasias da Mama/metabolismo , Análise Mutacional de DNA , Feminino , Humanos , Pessoa de Meia-Idade , Modelos Estatísticos , Polônia , Estudos ProspectivosRESUMO
An extremely rare case of primary adenocarcinoma of the tympanic cavity behind the intact tympanic membrane was presented. A radical surgical treatment and postoperative telegammatherapy was used, with no evidence of recurrence for four years. The authors have described the occurrence of this tumor in the temporal bone, clinical picture, diagnosis difficulties, prognosis and ways of therapy. They have paid attention to the guileful course of disease and non-characteristic symptoms in its initial stage.
