[Renal disease in ANCA-associated vasculitis]. / Atteintes rénales des vasculites associées aux ANCA.

ANCA-associated vasculitis are systemic disorders characterized by inflammation predominantly involving small vessels. They are the most frequent cause of rapidly progressive glomerulonephritis in the elderly. They originate from complex interactions between genes and environment, resulting in autoimmunity and the generation of antibodies directed against neutrophil cytoplasmic antigens (ANCA), which may have pathogenic potential. Immunosuppressant agents, particularly cyclophosphamide, have considerably improved the prognosis, but infectious complications and relapses remain frequent. Recently, rituximab has been shown to be a good alternative to cyclophosphamide to induce remission. Additional knowledge should result in better clinical outcomes, minimizing side effects.

[Aspirin as primary prevention for diabetic patients]. / L'aspirine en prévention primaire chez les patients diabétiques.

Several meta-analysis support the prescription of aspirin for primary prevention of cardiovascular events in patients at risk. Though diabetics are particularly prone to these complications, a review of the literature shows that they have fewer benefits from the protective effects of such treatment. In these patients, controlling dyslipidemia, blood pressure and glycemia remains the main aim. Prescription of aspirin, in combination with an already existing medication, should not be solely based on the presence of diabetes, but on the overall risk profile of the patient, as well as his motivation.