RESUMO
PURPOSE: This study aims to compare the ability of the PHI versus tPSA test to predict the presence of PCa in our population. METHODS: A prospective observational study was performed. We included patients with tPSA ≥ 2.5 ng/ml, biopsy naïve or previous negative biopsy, undergoing a blood test, which includes tPSA, fPSA, and p2PSA, and a prostate biopsy between March 2019 and March 2022. Patients with PCa found in the biopsy-Group A-were compared with patients with a negative biopsy result-Group B. Diagnostic accuracy of tPSA and PHI was assessed by receiver operating characteristic [ROC] curves and logistic regression. RESULTS: 140 men were included. Fifty-seven (40.7%) had a positive prostate biopsy result (Group A), and 83 (59.3%) had a negative biopsy result (Group B). The mean age was similar in both groups (mean ± standard deviation), 66.86 ± 6.61 years. No difference was found in the tPSA value between the groups (Group A PSA: 6.11 ng/ml (3.56-17.01); Group B: 6.42 ng/ml (2.46-19.45), p = 0.41). The mean value of PHI was statistically different between groups (Group A 65.50 (29-146) vs. Group B 48 (16-233), p = 0.0001). The area under the curve 0.44 for tPSA and 0.77 for PHI. The multivariate logistic regression model applied to PHI showed a significant increase in its predictive accuracy: 72.14% in the model without PHI, 76.09% with PHI. CONCLUSION: The PHI test improves PCa detection compared to tPSA in our population.
Assuntos
Antígeno Prostático Específico , Neoplasias da Próstata , Masculino , Humanos , Próstata/patologia , Neoplasias da Próstata/patologia , Curva ROC , Estudos Prospectivos , BiópsiaRESUMO
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Assuntos
Humanos , Feminino , Adulto , Neoplasias Fibroepiteliais/cirurgia , Neoplasias Ureterais/cirurgia , Tumores de Células Gigantes/cirurgia , Hidronefrose/etiologia , Pólipos/cirurgiaRESUMO
The ureteral fistulas are related to the gynecological surgery, digestive surgery and reconstructive urologic surgery of the upper urinary tract. Fistulas are described ureterovaginal, ureteroduodenal, ureterocolonic, ureteropleural, ureterovascular, etc. However, the ureterocutaneous fistulas of the ureteral stump after nephrectomy are a very unusual entity. We report two cases as well as their resolution by means of surgery.
Assuntos
Fístula Cutânea/etiologia , Nefrectomia/efeitos adversos , Doenças Ureterais/etiologia , Fístula Urinária/etiologia , Idoso , Fístula Cutânea/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Ureterais/cirurgia , Fístula Urinária/cirurgiaRESUMO
Las fístulas ureterales se relacionan con la cirugía ginecológica, cirugía digestiva y cirugía urológica reconstructiva del aparato urinario superior. Están descritas fístulas ureterovaginales, ureteroduodenales, ureterocolónicas, ureteropleurales, ureterovasculares, etc. Sin embargo, las fístulas ureterocutáneas del muñón ureteral tras nefrectomía son una entidad muy inusual. Presentamos dos casos así como su resolución mediante cirugía (AU)
The ureteral fistulas are related to the gynecological surgery, digestive surgery and reconstructive urologic surgery of the upper urinary tract. Fistulas are described ureterovaginal, ureteroduodenal, ureterocolonic, ureteropleural, ureterovascular, etc. However, the ureterocutaneous fistulas of the ureteral stump after nephrectomy are a very unusual entity. We report two cases as well as their resolution by means of surgery (AU)