RESUMO
E-cadherin and beta-catenin are component of adherens junctions in epithelial cells. Loss of these proteins have been associated with progression of prostatic diseases. We performed immunohistochemistry for E-cadherin, beta-catenin and Ki-67 on canine prostatic lesions. We analyzed the expression of these antibodies in benign prostatic hyperplasia (BPH, n = 22), in pre neoplastic lesions Prostatic Intra-epithelial Neoplasia (PIN), n = 3 and Prostatic Inflammatory Atrophy (PIA), n = 7 and prostate carcinoma (PC, n = 10). In this study, a membranous expression of E-cadherin and beta-catenin and nuclear expression of Ki-67 antigen were demonstrated. The proliferative index was statistically different between carcinomas and BPH and carcinomas and pre-neoplastic lesions. Like in men, the reduction of E-cadherin and increase of Ki-67 expression in neoplastic lesions in dog prostate may be related to the carcinogenic process in this gland.
Assuntos
Moléculas de Adesão Celular/metabolismo , Doenças do Cão/metabolismo , Hiperplasia Prostática/veterinária , Neoplasia Prostática Intraepitelial/veterinária , Neoplasias da Próstata/veterinária , Animais , Atrofia/metabolismo , Atrofia/patologia , Caderinas/metabolismo , Doenças do Cão/patologia , Cães , Inflamação/metabolismo , Inflamação/patologia , Antígeno Ki-67/metabolismo , Masculino , Hiperplasia Prostática/metabolismo , Hiperplasia Prostática/patologia , Neoplasia Prostática Intraepitelial/metabolismo , Neoplasia Prostática Intraepitelial/patologia , Neoplasias da Próstata/metabolismo , Neoplasias da Próstata/patologia , beta Catenina/metabolismoRESUMO
Supervision and evaluation of the direct care provider can be a costly and time-consuming activity. A comprehensive process to coordinate the various aspects of the home care aide evaluation is a creative solution for the efficient use of supervisory and staff time, paperwork reduction, and cost containment.
Assuntos
Cuidadores/normas , Avaliação de Desempenho Profissional/métodos , Serviços de Cuidados Domésticos/organização & administração , Supervisão de Enfermagem/métodos , Documentação , Controle de Formulários e Registros , Serviços de Assistência Domiciliar/organização & administração , Serviços de Assistência Domiciliar/normas , Serviços de Cuidados Domésticos/normas , Assistentes de Enfermagem/normas , Pennsylvania , Competência ProfissionalRESUMO
Responsibility, accountability, and authority are the tools of primary nursing that enable nurses to impact patient care. It is important to determine if nurses empowered by a primary nursing care delivery system can positively influence patient outcomes. The authors describe an outcome audit conducted to study patient satisfaction with nursing care, one indicator of quality patient care.