Prostatic carcinosarcoma: a case originating in a previous ductal adenocarcinoma of the prostate.

Ductal adenocarcinoma of the prostate is a variant of prostatic carcinoma that appears to originate in the ducts of the prostate. Carcinosarcoma of the prostate is an uncommon and aggressive tumour composed of an intimate admixture of adenocarcinoma and sarcoma. In this report we describe the clinicopathological and immunohistochemical characteristics of a case of prostatic carcinosarcoma that appeared in a 66-year-old man who had had a ductal adenocarcinoma of the prostate diagnosed 3 years previously. The patient died of the disease 3 months after the carcinosarcoma was diagnosed. This case may represent further evidence of the dedifferentiation theory in the origin of carcinosarcoma. The case also illustrates that this dedifferentiation may occur from any type of prostatic carcinoma.

[Necrotizing histiocytic lymphadenitis (Kikuchi-Fujimoto disease): contribution of 2 cases]. / Linfadenitis histiocítica necrotizante (enfermedad de Kikuchi-Fujimoto): aportación de dos casos.

The necrotizing lymphadenitis of Kikuchi-Fujimoto is an uncommon disease in Spain. In a review of the literature we found only five cases reported until 1995. We report here two patients with the diagnosis of this entity in an area hospital during a one-year period. This fact contrasts with the low frequency of this disease reported so far in our country. The cases were two young women who were investigated because of cervical lymph node enlargement and headache. The lymph node biopsy revealed typical findings of the necrotic phase of the Kikuchi-Fujimoto disease in one case; the histology in the other case was characteristic of the so called proliferative phase. The two patients evolved spontaneously with a favorable outcome. Lymph node enlargements resolved in less than three months. All microbiological investigations performed were negative. One of the two patients was receiving intranasal calcitonin when symptoms developed. The incidence of Kikuchi-Fujimoto disease might be higher than considered. The spontaneous resolution of the disease and the requirement of the histological examination for its diagnosis are factors limiting its identification.